Cord Blood News 10.31 August 9, 2018 | |
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TOP STORYResearchers found that umbilical cord MSCs (UC-MSCs) were effective in restoring impaired alveolar fluid clearance and protein permeability of H5N1-infected alveolar epithelial cells. However, UC-MSCs only slightly improved survival of H5N1-infected mice. [J Infect Dis] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)While the infusion of human umbilical cord matrix cells (HUCMCs) reduced spinal cord hemorrhage and increased systemic levels of IL-10 in the presence of a spleen, these effects were lost with splenectomy. HUCMC infusion was shown to alter the expression levels of splenic cytokines, suggesting that the spleen is an important target and site of MSC effects. [J Neuroinflammation] Full Article Scientists used the piggyBac transposon-based simian virus 40 T antigen immortalization system and effectively immortalized umbilical cord-MSCs, yielding the iUC-MSCs. Upon bone morphogenetic protein 9 (BMP9) stimulation, the iUC-MSCs effectively differentiated into osteogenic, chondrogenic, and adipogenic lineages both in vitro and in vivo, which were indistinguishable from that of primary UC-MSCs. [J Cell Biochem] Abstract Due to its contradictory and temporally variable effects on different cell types, investigators sought to investigate whether and how the TGF-β signaling pathway regulates the osteogenic differentiation of cord blood-derived unrestricted somatic stem cells. [J Cell Biochem] Abstract The neuroregulatory potential of adipose tissue (ASC), bone-marrow and umbilical cord conditioned media (CM) in promoting neurodifferentiation and axonal outgrowth was tested in vitro, using human telencephalon neuroprogenitor cells and dorsal root ganglion explants, respectively. All the MSC populations promoted the same extent of neurodifferentiation, while ASC CM demonstrated higher potential in promoting axonal growth. [Biochimie] Abstract The genomic sequences within 500 base pairs upstream and downstream of fourteen transplantation-related single nucleotide polymorphisms (SNPs) from 53 patients and their human leukocyte antigen (HLA)-matched unrelated donors were analyzed for determining whether or not genetic variants, conferred by either recipient or donor SNP genotype or by recipient-donor SNP mismatching, were associated with the risk of relapse. [PeerJ] Full Article Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSAmniotic Fluid Stem Cells for the Treatment of Surgical Disorders in the Fetus and Neonate The authors give a brief overview of the rationale and current status of amniotic fluid stem cell-based therapies, focusing on its relevance to birth defects affecting the fetus and neonate. They propose a roadmap for further study that would be required prior to clinical application of amniotic fluid stem cell technologies. [Stem Cells Transl Med] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSThe University of Texas MD Anderson Cancer Center and Jazz Pharmaceuticals plc announced a five-year collaboration agreement with a goal of evaluating therapies for multiple hematologic malignancies, including acute myeloid leukemia and myelodysplastic syndromes. [The University of Texas MD Anderson Cancer Center] Press Release Nohla Therapeutics announced that the FDA has granted Fast Track designation to dilanubicel for patients with high-risk hematologic malignancies receiving an allogeneic cord blood transplant. [Nohla Therapeutics] Press Release | |
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POLICY NEWSIndia Cracks Down on Plagiarism at Universities India has for the first time introduced regulations to detect and punish acts of plagiarism at universities. [Nature News] Editorial Japanese Medical University Admits to Discriminating against Female Applicants A prominent Japanese medical university said that school administrators have deliberately manipulated entrance exam scores to limit the number of women admitted. The confession helps explain the lopsided gender ratio of graduates from Tokyo Medical University and strengthens suspicions that similar practices have prevailed at other Japanese medical schools. [ScienceInsider] Editorial Top US Biomedical Institute Settles Gender-Discrimination Lawsuits The Salk Institute has reached a deal with two of three female scientists who alleged unequal treatment. Cancer researchers Katherine Jones and Victoria Lundblad have agreed to drop all claims against the institute in La Jolla, California, according to a joint statement released. [Nature News] Editorial Embattled French Health-Agency Chief Withdraws Leadership Bid The chief of France’s national biomedical-research agency INSERM has said that he will not run for a second term, a decision that ends months of uncertainty about his future at the organization. [Nature News] Editorial
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JOB OPPORTUNITIESFaculty Investigator – Cancer (University of Alabama at Birmingham) Postdoctoral Scientist – Leukemia Biology (University of Oxford) Assistant or Associate Professor – Stem Cell Transplantation (Dana-Farber Cancer Institute) Scientific Research Positions – Various Subjects (Shanghai General Hospital) Postdoctoral Position – Cancer Drug Discovery (University of Michigan) Postdoctoral Associate – Cancer Biology (Trustees of Boston University Medical Campus) Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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