Cord Blood News 10.33 August 23, 2018 | |
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TOP STORYWhile cold-induced apoptosis was independent of the residual plasma concentration, cold storage was associated with better adhesive properties and higher response to activators. An extended study to assess cold-stored platelet concentrates produced under standard care GMP conditions showed that platelet function, metabolism and integrity were better compared to those stored at room temperature. [Haematologica] Abstract | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers developed an improved method for generating mismatched humanized mice, using a dual infusion of human hematopoietic stem and progenitor cells and mesenchymal stem cells, isolated from cord blood and expanded in vitro. Higher humanization was associated with in vivo response to immune-directed therapy. [Mol Carcinog] Abstract | Press Release The CURE-iv trial was a Phase I, uncontrolled, open label trial for rheumatoid arthritis patients with moderate disease activity despite treatment with methotrexate. Reduced levels of IL-1β, IL-6, IL-8, and TNF-α at 24 hours were observed in the cluster infused with 1 × 108 MSCs. [Stem Cells Transl Med] Full Article Umbilical cord tissue-MSCs expanded using platelet lysate (PL) displayed typical immunophenotype, plasticity, immunomodulatory property and chromosomal stability. PL supplementation showed two-fold increase in MSC yield from explant culture with improved immunomodulatory activity as compared to enzymatically dissociated cultures. [Sci Rep] Full Article The therapeutic effect of repeated infusions of human bone marrow MSCs (bmMSCs), umbilical cord MSCs (ucMSCs), kidney perivascular cells (kPSCs) or conditioned medium from ucMSCs was studied in athymic rats with adriamycin-induced nephropathy. BmMSCs and kPSCs, but even more so ucMSCs, limited proliferation, migratory potential and extracellular matrix production of activated parietal epithelial cells, when cultured in a transwell system. [Stem Cell Res Ther] Full Article After culture in decellularized Wharton’s jelly matrix (DWJM), leukemia cells exhibited changes in morphology, acquiring a spindle-shaped appearance, and an increase in the ALDH+ cell population. When treated with a high-dose of doxorubicin, leukemia cells in DWJM demonstrated less apoptosis compared with cells in suspension. [Leuk Res] Abstract | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSAdvances in Perinatal Stem Cells Research: A Precious Cell Source for Clinical Applications The authors highlight the characteristics and potential clinical applications in regenerative medicine of perinatal stem cell sources – cord blood hematopoietic stem cells, umbilical cord MSCs, amniotic membrane stem cells, amniotic fluid stem cells, amniotic epithelial cells and chorionic MSCs. [Regen Med] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSTolero Pharmaceuticals, Inc. has entered into a clinical research collaboration with AbbVie, exploring the potential of combination therapy with AbbVie’s venetoclax and Tolero’s investigational agent, alvocidib, for the treatment of relapsed/refractory acute myeloid leukemia. [Tolero Pharmaceuticals, Inc.] Press Release StemExpress Expands into Clinical Market StemExpress announced the release of Clinical Grade Non-Transfusable products to customers developing studies relating to transplantation, cell therapy, regenerative medicine, investigational new drug development, and the research and development of medical devices in preclinical and clinical phases. [StemExpress] Press Release Imago BioSciences announced that the Phase I/IIa clinical trial of IMG-7289 for the treatment of high-risk acute myeloid leukemia and high-risk myelodysplastic syndrome has fully enrolled at 45 patients. [Imago BioSciences] Press Release Lixte Biotechnology Holdings, Inc. announced that it has entered into a clinical trial agreement and exclusive license agreement with Moffitt Cancer Center to conduct a Phase Ib/II study of the safety and therapeutic benefit of Lixte’s lead clinical compound, LB-100, in patients with myelodysplastic syndrome. [Lixte Biotechnology Holdings, Inc. (Globe Newswire, Inc.)] Press Release NYU Langone’s Blood & Marrow Transplant Program Expands Services To further advance the study and treatment of blood cancers, Perlmutter Cancer Center at NYU Langone Health has significantly expanded its Blood and Marrow Transplant Program. [NYU Langone Hospitals] Press Release | |
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POLICY NEWSIn Defiance of Trump’s Budget, Senate Poised to Boost NIH Funding—Again Ignoring President Donald Trump’s proposed budget, the Senate is setting up to approve a $2 billion boost in funding for the National Institutes of Health (NIH). [Fierce Biotech] Editorial The National Institutes of Health (NIH) is investigating roughly a half-dozen research institutions based on suspicions that researchers with federal grants failed to disclose significant financial contributions from foreign governments. [STAT News] Editorial Trump Science-Adviser Pick Faces US Senate Committee Meteorologist Kelvin Droegemeier is in the hot seat, speaking before a US Senate committee during a hearing on his nomination to head the White House Office of Science and Technology Policy. [Nature News] Editorial Japanese Authorities Recommend Not Regulating Gene Editing A Japanese government panel announced that it recommends regulating only genetically modified organisms that have had foreign genes permanently introduced into their genomes and not those whose endogenous genes have been edited. This means that developers will not have to get approval from the government to produce gene-edited organisms. [The Scientist] Editorial
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EVENTSNEW The 23rd Annual Congress of Asia-Pacific Blood and Marrow Transplantation Group (APBMT 2018) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Institute Sr Research Scientist – Flow Cytometry (MD Anderson Cancer Center) Post-Doctoral Fellow or Research Scientist – Transplant Immunology (Medical College of Wisconsin) Faculty Investigator – Cancer (University of Alabama at Birmingham) Assistant or Associate Professor – Stem Cell Transplantation (Dana-Farber Cancer Institute) Scientific Research Positions – Various Subjects (Shanghai General Hospital) Postdoctoral Position – Cancer Drug Discovery (University of Michigan) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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