Cord Blood News Volume 11.13 | Apr 11 2019

TOP STORY

Therapeutic Effects of a Single Injection of Human Umbilical Mesenchymal Stem Cells on Acute and Chronic Colitis in Mice

Scientists report the therapeutic effects of a single injection of human umbilical cord mesenchymal stem cells on acute and chronic colitis. [Sci Rep] Full Article

(Ranked by impact factor of the journal)

MicroRNA Expression Profiles in Two‐ and Three‐Dimensional Culture Conditions of Human‐Umbilical‐Cord Blood‐Derived CD34⁺ Cells

Researchers studied umbilical cord blood (UCB)‐derived CD34⁺ cell expansion and the miRNA signatures of CD34⁺ cells on two‐ and three‐dimensional culture conditions. They successfully expanded the UCB‐derived CD34⁺ cells in both liquid culture and on aminated polyethersulfone nanofiber scaffolds. [J Cell Physiol] Abstract

Therapeutic Effect of Long‐Interval Repeated Intravenous Administration of Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells in DBA/1 Mice with Collagen‐Induced Arthritis

The authors investigated the effects of long‐interval repeated intravenous administration of human umbilical cord blood‐derived‐MSCs at different doses in a CIA mice model. [J Tissue Eng Regen Med] Abstract

Effects of Transplanted Umbilical Cord Blood Mononuclear Cells Overexpressing GDNF on Spatial Memory and Hippocampal Synaptic Proteins in a Mouse Model of Alzheimer’s Disease

Umbilical cord blood mononuclear cells were transduced with adenoviral vectors expressing glial cell line-derived neurotrophic factor (GDNF) and injected into Alzheimer’s disease transgenic mice. Various parameters including homing and survival of transplanted cells, expression of GDNF and synaptic proteins, as well as spatial memory were evaluated. [J Alzheimers Dis] Abstract

Differentiation Potential of Different Regions-Derived Same Donor Human Wharton’s Jelly Mesenchymal Stem Cells into Functional Smooth Muscle-Like Cells

Investigators evaluated the transdifferentiation potential of different region-derived same donor Wharton’s jelly MSCs into functional smooth muscle-like cells. [Cell Tissue Res] Abstract

The Influence of Stem Cell Source on Transplant Outcomes for Pediatric Patients with Acute Myeloid Leukemia

Post-hematopoietic stem cell transplant (HSCT) relapse is a common cause of mortality, and complications such as chronic graft versus host disease are debilitating and life-threatening. To compare post-HSCT outcomes of different donor sources, the authors retrospectively analyzed consecutive transplants performed in several international centers from 2005 to 2015. [Blood Adv] Full Article | Graphical Abstract

Decellularized Wharton Jelly Matrix: A Biomimetic Scaffold for Ex Vivo Hematopoietic Stem Cell Culture

Researchers evaluated a novel 3D in vitro culture system that used components of the bone marrow hematopoietic niche to expand umbilical cord blood CD34⁺ cells. [Blood Adv] Full Article | Graphical Abstract

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Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application

The authors discuss the main aspects to be considered to define standard operation procedures for the creation of an induced pluripotent stem cell bank using cord blood—or similar cell type—bank guidelines for clinical aims. [J Clin Med] Abstract | Download Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

University of Birmingham Trials a New Stromal Cell Immunotherapy for Chronic Liver Disease

The University of Birmingham has launched a trial that could lead to a ground-breaking new way of treating people with two types of chronic liver disease. Up to 56 patients are being recruited to take part in the MERLIN trial, which will investigate the safety and efficacy of a new cellular immunotherapy in patients with either primary sclerosing cholangitis or autoimmune hepatitis. [University of Birmingham] Press Release

Leading Myeloma Experts to Join New Center for Blood Cancers at NYU Langone Health

Nationally renowned hematology experts Gareth Morgan, MD, PhD, and Faith E. Davies, MD, are joining the Center for Blood Cancers at NYU Langone Health’s Perlmutter Cancer Center to lead its Multiple Myeloma Program. [NYU Langone Hospitals] Press Release

Impact Factors Are Still Widely Used in Academic Evaluations

About 40% of institutes with a strong focus on research mention impact factors in documents used in the review, promotion and tenure process, according to the analysis, which examined more than 800 documents across 129 institutions in the United States and Canada. [Nature News] Editorial

FDA, New York Attorney General Go After Stem Cell Clinics

On April 3, the FDA sent letters to 20 companies providing stem cell treatments, reports The New York Times, reminding them that they may require FDA approval and should take action to comply. The agency also issued a warning to a stem cell company for violating good manufacturing practices. [The Scientist] Editorial

NEW Cold Spring Harbor Laboratory: Stem Cell Biology
September 17-21, 2019
Copenhagen, Denmark

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NEW Researcher Position – Cell Signaling (University of Tromsø)

NEW Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern)

NEW Assistant, Associate, or Full-Professor Positions – Cancer Research (Brown University)

NEW Postdoctoral Research Fellow – Functional Genomics (Justus Liebig University Giessen)

Postdoctoral Fellows – Hematological Malignancies and Cancer Immunology (Fox Chase Cancer Center)

Postdoctoral Position – Mechanobiology (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Hematopoietic Stem Cells (Washington University School of Medicine)

Postdoctoral Fellow Positions – Human iPS cells, Epigenetics, Hematopoietic Stem Cell Biology, and Blood Cancers (Nationwide Children’s Hospital & Ohio State University)

Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois at Chicago)

Faculty Positions – Cancer Research (Shenzhen University)

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