Cord Blood News Volume 11.14 | Apr 18 2019

TOP STORY

Umbilical Cord Blood versus Unrelated Donor Transplantation in Adults with Primary Refractory or Relapsed Acute Myeloid Leukemia: A Report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the EBMT

The authors compared transplantation outcomes of 2963 patients with primary refractory or relapsed acute myeloid leukemia given cord blood transplantation, 10/10 HLA-matched UD, or 9/10 HLA-matched UD allo-allogeneic hematopoietic cell transplantation from 2004 to 2015 at EBMT-affiliated centers. [Blood Cancer J] Full Article

(Ranked by impact factor of the journal)

Metabolites Can Regulate Stem Cell Behavior through the STAT3/AKT Pathway in a Similar Trend to That under Hypoxic Conditions

Researchers selected several metabolites to examine the relation between metabolites and stem cell functions. In addition, they investigated the ability of selected metabolites to induce rapid expansion of this cell population. [Sci Rep] Full Article

Safety of Intratracheal Administration of Human Umbilical Cord Blood Derived Mesenchymal Stromal Cells in Extremely Low Birth Weight Preterm Infants

In a Phase I dose-escalation trial at two dosing levels, the authors assessed the safety of intratracheal administration of a single-dose of human umbilical cord blood-derived mesenchymal stromal cells in 12 extremely low birth weight infants <28 weeks of gestation and <1000 g at birth at 5-14 days of life. [J Pediatr] Abstract

Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Exert Antiapoptosis Effect via Activating PI3K/Akt/mTOR Pathway on H9C2 Cells

Researchers investigated the role of human umbilical cord mesenchymal stem cell derived exosomes play on H9C2 cells apoptosis and possible mechanisms. [J Cell Biochem] Abstract

Human Umbilical Cord‐Derived Scaffolds for Cartilage Tissue Engineering

Scientists showed that human bone marrow‐derived‐MSCs in tissue‐derived scaffolds had an increased expression of chondrogenic markers compared with gelatin, whereas there were no significant differences between expression of hypertrophic and osteogenic markers between tissue and gelatin scaffolds. [J Biomed Mater Res A] Abstract

Proteomic Analysis of Human Mesenchymal Stromal Cell Secretomes: A Systematic Comparison of the Angiogenic Potential

Investigators compared angiogenesis of human mesenchymal stromal cell (hMSC) secretomes from adipose tissue, bone marrow, and umbilical cord Wharton’s jelly. hMSC secretomes were obtained under xenofree conditions and analyzed by liquid chromatography tandem mass spectrometry. [npj Regen Med] Full Article

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Manufacturing and Characterization of Extracellular Vesicles from Umbilical Cord-Derived Mesenchymal Stromal Cells for Clinical Testing

On the basis of in vitro and in vivo findings regarding the biological actions of extracellular vesicles (EVs) and experience in manufacturing biological stem cell therapeutics for routine use and clinical testing, the authors discuss strategies of manufacturing and quality control of umbilical cord-derived MSC-EVs. [Cytotherapy] Full Article

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Versiti Blood Research Institute Awarded Multi-Million Dollar REDS-IV Blood Study Contract

Versiti Blood Research Institute has been awarded a seven-year federal contract valued at $7.4 million from the US Department of Health & Human Services to participate in the National Heart, Lung, and Blood Institute’s research program to protect the nation’s blood supply and improve the collection and use of blood products. [Versiti Blood Research Institute] Press Release

Celularity Enters Lease to Develop Advanced Cell Manufacturing and Research Facility for Commercial-Scale Placental-Derived Allogeneic Cell Therapies

Celularity, Inc. announced the company has entered into a long-term lease agreement to develop a 145,000 square-foot advanced cell manufacturing and research facility in Florham Park, New Jersey. [Celularity, Inc. (Business Wire, Inc.)] Press Release

How US-China Political Tensions Are Affecting Science

In the latest twist, several US universities are expected to announce the actions they have taken against foreign scientists caught breaking rules concerning National Institutes of Health funding, according to comments made by agency director Francis Collins to the Senate Appropriations Committee. [Nature News] Editorial

‘Friendly’ Reviewers Rate Grant Applications More Highly

Peer reviewers are four times more likely to give a grant application an “excellent” or “outstanding” score rather than a “poor” or “good” one when they are chosen by the grant’s applicants, an analysis of Swiss funding applications has found. [Nature News] Editorial

Indian Scientists Launch Preprint Repository to Boost Research Quality

Researchers in India will soon have their own preprint repository where they can post manuscripts from any discipline. The founders of IndiaRxiv hope it will improve the quality of science in the country. [Nature News] Editorial

NEW Blood Disorders: Models, Mechanisms and Therapies
September 29-October 1, 2019
Boston, Massachusetts, United States

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NEW Postdoctoral Researcher – Stem Cells and Erythropoiesis in MDS (Karolinska Institutet)

Researcher Position – Cell Signaling (University of Tromsø)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern)

Assistant, Associate, or Full-Professor Positions – Cancer Research (Brown University)

Postdoctoral Research Fellow – Functional Genomics (Justus Liebig University Giessen)

Postdoctoral Fellows – Hematological Malignancies and Cancer Immunology (Fox Chase Cancer Center)

Postdoctoral Position – Mechanobiology (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Hematopoietic Stem Cells (Washington University School of Medicine)

Postdoctoral Fellow Positions – Human iPS cells, Epigenetics, Hematopoietic Stem Cell Biology, and Blood Cancers (Nationwide Children’s Hospital & Ohio State University)

Assistant Professor – Computational Biology/Stem Cell Biology (University of Illinois at Chicago)

Faculty Positions – Cancer Research (Shenzhen University)

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