Cord Blood News Volume 11.29 | Aug 1 2019

TOP STORY

The Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cell Transplantation on Endometrial Receptivity Are Associated with Th1/Th2 Balance Change and uNK Cell Expression of Uterine in Autoimmune Premature Ovarian Failure Mice

Following human umbilical cord-derived MSC transplantation, the serum levels of estrogen, progesterone, and interleukin (IL)-4 were increased but follicle stimulating hormone, γ-interferon, and IL-2 levels were decreased in premature ovarian failure mice. [Stem Cell Res Ther] Full Article

(Ranked by impact factor of the journal)

Cord Blood Granulocytic Myeloid-Derived Suppressor Cells Impair Monocyte T Cell Stimulatory Capacity and Response to Bacterial Stimulation

The impact of human cord blood myeloid-derived suppressor cells (CB-MDSCs) on monocytes was investigated in an in vitro model. CB-MDSCs were co-cultured with peripheral blood mononuclear cells and monocytes were analysed for expression of surface markers, T cell stimulatory and phagocytic capacity, as well as the production of intracellular cytokines by flow cytometry. [Pediatr Res] Abstract

Isogenic-Induced Endothelial Cells Enhance Osteogenic Differentiation of Mesenchymal Stem Cells on Silk Fibroin Scaffold

Researchers investigated the role of induced endothelial cells (iECs) in MSC/iEC co-culture and assessed their osteogenic ability on silk fibroin nanofiber scaffolds. [Regen Med] Full Article | Graphical Abstract

Anti-Proliferative Effects of Mesenchymal Stem Cells (MSCs) Derived from Multiple Sources on Ovarian Cancer Cell Lines: An In-Vitro Experimental Study

The co-culture of cancer cell lines OVCAR3, CAOV3, IGROV3 and SKOV3 with the conditioned media of MSCs and MSCs showed an increase in cellular apoptosis, along with a reduction in the level of CA-125 and a decline of LDH and beta-hCG. [J Ovarian Res] Full Article

Impact of the Type of Microcarrier and Agitation Modes on the Expansion Performances of Mesenchymal Stem Cells Derived from Umbilical Cord

Investigators compared the impact of agitation mode on the culture of MSCs extracted from the Wharton’s jelly of umbilical cords, in a clinical grade culture medium, using human platelet lysate and different xeno‐free microcarriers. [Biotechnol Prog] Abstract

HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 Allele and Haplotype Frequencies: An Analysis of Umbilical Cord Blood Units at the Barcelona Cord Blood Bank

The authors analyzed HLA‐A, ‐B, ‐C, ‐DRB1, and ‐DQB1 allele frequencies in 5458 high‐quality cord blood units from the Barcelona Cord Blood Bank and identified 275 class I and 121 class II HLA alleles. [HLA] Abstract

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Immunotherapy for Acute Myeloid Leukemia: From Allogeneic Stem Cell Transplant to Novel Therapeutics

The authors provide an overview of the graft versus leukemia effect in acute myeloid leukemia (AML) as a window into understanding the prospects of AML immunotherapy. They explore the roles of various cell types in orchestrating anti-leukemic immunity, as well as those contributing to the unique immune suppressive state of myeloid diseases. [Leuk Lymphoma] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

OUHSC Receives $18.7M Grant for Biomedical Research, Workforce Development

The University of Oklahoma Health Sciences Center (OUHSC) has received an $18.7 million grant from the National Institutes of Health to expand biomedical research for some of the most complex diseases and to develop the workforce to take that research into the future. [The University of Oklahoma (EurekAlert)] Press Release

Momenta Pharmaceuticals Announces Fast Track Designation for M281 (Nipocalimab) in Hemolytic Disease of the Fetus and Newborn (HDFN)

Momenta Pharmaceuticals, Inc. announced that the FDA has granted Fast Track designation for M281, Momenta’s IgG1 monoclonal antibody targeting FcRn, in HDFN. HDFN is a serious blood disorder in a fetus or newborn that occurs when red cell incompatibility exists between the blood types of a mother and baby. [Momenta Pharmaceuticals, Inc.] Press Release

‘No One Is Immune’: Alaska’s Scientists Despair over Plan to Shrink State Universities

The University of Alaska’s governing board plans to consolidate campuses to cope with a 40% cut in state funding. [Nature News] Editorial

Survey of Stem Cell Clinics Reveals Cause for Concern

Two coauthors of a new study discuss their findings about nearly 170 facilities in the southwestern US selling unproven therapies—and what should be done about them. [The Scientist] Editorial

China’s Scientists Alarmed, Bewildered by Growing Anti-Chinese Sentiment in the United States

Scientists in China are concerned about what they see as growing anti-Chinese sentiment in the United States. They dismiss claims of a vast conspiracy to steal US intellectual property and worry that new visa restrictions, scrutiny of export of scientific devices, and US investigations of Chinese and Chinese American scientists will hinder international collaborations. That could harm both countries’ research efforts as well as global scientific progress, many say. [ScienceInsider] Editorial

NEW 8^th Annual International Symposium on Regenerative Rehabilitation
October 24-26, 2019
Charlottesville, Virginia, United States

Visit our events page to see a complete list of events in the community.

NEW Associate Professor – Pediatrics (Pennsylvania State University)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Early Stage Researchers – Hematopoiesis (Multiple Locations)

Faculty Positions – Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco)

Postdoctoral Research Associate – Development, Regeneration and Cell Fate (Michigan State University)

Tenure-Track Positions – Stem Cell Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Postdoctoral Researcher – Next Generation Cell Therapy Process Engineering (University of British Columbia)

Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Leukemia (University of California, San Francisco)

Research Associate – Oncology and Hematology (University of Manitoba)

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