Cord Blood News Volume 11.39 | Oct 10 2019

TOP STORY

Expansion of Primitive Human Hematopoietic Stem Cells by Culture in a Zwitterionic Hydrogel

Using 3D culture of human hematopoietic stem and progenitor cells (HSPCs) in a degradable zwitterionic hydrogel, scientists achieved substantial expansion of phenotypically primitive CD34⁺ cord blood and bone-marrow-derived HSPCs. [Nat Med] Abstract

(Ranked by impact factor of the journal)

The Tumor-Immune Response Is Not Compromised by Mesenchymal Stromal Cells in Humanized Mice

The authors investigated the impact of human umbilical cord-derived MSCs on tumor growth in humanized mice generated by the human adoptive transfer of PBMCs or the cotransplantation of hematopoietic stem cells and human thymic tissue. [J Immunol] Abstract

Human Mesenchymal Stem Cell Sheets in Xeno-Free Media for Possible Allogenic Applications

To address allogeneic cell therapy limitations, researchers developed a new allogeneic stem cell sheet using human umbilical cord MSCs that presented low antigenicity. [Sci Rep] Full Article

Human Mesenchymal Stem Cells-Derived Conditioned Medium Inhibits Hypoxia‐Induced Death of Neonatal Porcine Islets by Inducing Autophagy

Scientists investigated if human umbilical cord‐derived MSCs could ameliorate hypoxia‐induced apoptosis in porcine islets by modulating autophagy, and they explored the underlying mechanisms. [Xenotransplantation] Abstract

Impact of Pretransplant Donor-Specific Anti-HLA Antibodies on Cord Blood Transplantation on Behalf of the Transplant Complications Working Group of Japan Society for Hematopoietic Cell Transplantation

Investigators conducted a retrospective analysis of recipients of single-unit cord blood transplantation with pretransplant anti-HLA antibodies using the database of Japan Society for Hematopoietic Cell Transplantation. [Bone Marrow Transplant] Abstract

Wharton’s Jelly-Derived Mesenchymal Stem Cells Attenuate Sepsis-Induced Organ Injury Partially via Cholinergic Anti-Inflammatory Pathway Activation

Wharton’s jelly-derived MSC (WJ-MSC) treatment attenuated diastolic dysfunction and restored baroreflex sensitivity. WJ-MSCs also increased cardiac sympathetic and cardiovagal activity. [Am J Physiol Regul Integr Comp Physiol] Abstract

Me₂SO- and Serum-Free Cryopreservation of Human Umbilical Cord Mesenchymal Stem Cells Using Electroporation-Assisted Delivery of Sugars

The effect of electroporation-assisted pre-freeze delivery of sucrose, trehalose and raffinose into human umbilical cord MSCs on their post-thaw survival was investigated. [Cryobiology] Abstract

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Systematic Review of Controlled Clinical Studies Using Umbilical Cord Blood for Regenerative Therapy: Identifying Barriers to Assessing Efficacy

Clinical use of umbilical cord blood for novel indications in regenerative therapy continues to rise, however, whether new indications are proven is less clear. An updated systematic search of the literature, focusing only on controlled clinical studies, is needed to properly assess potential efficacy. [Cytotherapy] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

ElevateBio Launches HighPassBio to Advance Novel Targeted T Cell Immunotherapies with Technology from Fred Hutchinson Cancer Research

ElevateBio announced it has established and launched HighPassBio, a company dedicated to advancing novel targeted T cell immunotherapies. [ElevateBio] Press Release

Cabaletta Bio Receives IND Clearance from FDA to Initiate First Clinical Trial of DSG3-CAART in Patients with Mucosal Pemphigus Vulgaris

Cabaletta Bio, Inc. announced that it has received clearance of its Investigational New Drug (IND) application from the FDA to initiate a first-in-human clinical trial of desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) in patients with mucosal pemphigus vulgaris to assess the safety and tolerability of DSG3-CAART in these patients. [Cabaletta Bio, Inc.] Press Release

Biologists Who Decoded How Cells Sense Oxygen Win Medicine Nobel

A trio of researchers has won the 2019 Nobel Prize in Physiology or Medicine for describing how cells sense and respond to changing oxygen levels by switching genes on and off — a discovery that has been key in understanding human diseases such as cancer and anaemia. [Nature News] Editorial

NIH Marquee Awards for ‘High Risk, High Reward’ Projects Skew Male—Again

For three of the four types of “high risk, high reward” awards, women won in numbers that met or exceeded their representation in the applicant pool. However, that representation was meager: 18% percent to 38% of the applicants for these four awards were women, although women have earned more than 50% of US PhDs in biological sciences in every year since 2008. [ScienceInsider] Editorial

NEW From Stem Cells to Genes to Therapies
November 13-15, 2019
Brisbane, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Versiti Blood Research Institute)

Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Blood Research Institute)

PhD Positions – Cancer and Developmental Biology (Peter MacCallum Cancer Centre)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Postdoctoral Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Research Associate – Human IPSC Culture (Bayer)

Chair – Inflammation and Hematopoiesis (Technische Universität Dresden)

Tenure-Track Faculty Position – Stem Cell Biology (Albert Einstein College of Medicine)

Faculty Position – Hematopoietic Biology and Malignancy (The University of Texas MD Anderson Cancer Center)

Postdoctoral Research Associate – Solid Tumors and Leukemia (St. Jude Children’s Research Hospital)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

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