Cord Blood News Volume 12.07 | Feb 27 2020

TOP STORY

Magnetic Targeted Delivery of the SPIONs-Labeled Mesenchymal Stem Cells Derived from Human Wharton’s Jelly in Alzheimer’s Rat Models

Behavioral examinations showed that Wharton’s jelly-derived MSCs caused memory and cognitive improvement. Histological assessments showed functional improvement of hippocampal cells by expression of choline acetyltransferase and acetylcholinesterase. [J Control Release] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Identification of Osteolineage Cell-Derived Extracellular Vesicle Cargo Implicated in Hematopoietic Support

The treatment of umbilical cord blood-derived CD34⁺ hematopoietic stem and progenitor cells (HSPCs) with stimulatory extracellular vesicles (EVs)-altered HSPC transcriptome, including genes with known roles in cell proliferation. An integrative bioinformatics approach, which connected the HSPC gene expression data with the candidate cargo in stimulatory EVs, delineated the potentially targeted biological functions and pathways during hematopoietic cell expansion and development. [FASEB J] Full Article

Inhibition of Growth of Asian Keloid Cells with Human Umbilical Cord Wharton’s Jelly Stem Cell-Conditioned Medium

Asian keloid cells exposed to human Wharton’s jelly stem cell-conditioned medium in vitro showed significant decreases in cell viability and proliferation, increases in annexin V-FITC⁺ cell numbers, interruptions of the cell cycle at Sub-G1 and G2/M phases, altered CD marker expression, downregulated anti-apoptotic-related genes, and upregulated pro-apoptotic and autophagy-related genes compared to controls. [Stem Cell Res Ther] Full Article

Purifying Stem Cell-Derived Red Blood Cells: A High-Throughput Label-Free Downstream Processing Strategy Based on Microfluidic Spiral Inertial Separation and Membrane Filtration

Previously characterized mechanical properties of umbilical cord blood CD34⁺ cells undergoing in vitro erythropoiesis were used to develop a manufactured red blood cell purification strategy. The approach consisted of two main stages: a microfluidic separation using inertial focusing for deformability-based sorting of enucleated cells from nuclei and nucleated cells resulting in 70% purity and membrane filtration to enhance the purity to 99%. [Biotechnol Bioeng] Abstract

Functional Omics Analyses Reveal Only Minor Effects of MicroRNAs on Human Somatic Stem Cell Differentiation

Scientists evaluated the impact of miRNAs on the proteome of human umbilical cord blood-derived unrestricted somatic stem cells during retinoic acid differentiation by a systemic approach using next generation sequencing analysing mRNA and miRNA expression and quantitative mass spectrometry-based proteome analyses. [Sci Rep] Full Article

Monocytes from Neonates and Adults Have a Similar Capacity to Adapt Their Cytokine Production after Previous Exposure to BCG and β-Glucan

Investigators studied the capacity of Bacillus Calmette-Guérin (BCG) and β-glucan to induce a similar phenotype by examining cytokine production in cord blood monocytes following re-stimulation. They used a well-known model of in vitro induction of trained immunity. [PLoS One] Full Article

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Expanded Differentiation Capability of Human Wharton’s Jelly Stem Cells: A Systematic Review

The authors carried out a systematic review to determine the multilineage differentiation potential of human Wharton’s jelly stem cells (HWJSCs). They showed that HWJSCs displayed expanded differentiation potential towards some cell types corresponding to all three embryonic cell layers, which was consistent with their constitutive expression of key pluripotency markers such as OCT4, SOX2 and NANOG, and the embryonic marker SSEA4. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

WPD Pharmaceuticals’ Annamycin Received Positive Interim Results from Phase I/II Clinical Studies in Acute Myeloid Leukemia

WPD Pharmaceuticals Inc. provided an update on the clinical drug studies of Annamycin in acute myeloid leukemia. [WPD Pharmaceuticals Inc.] Press Release

SELLAS Announces Positive Follow-Up Phase I/II Clinical Data for Galinpepimut-S (GPS) in Acute Myeloid Leukemia (AML)

SELLAS Life Sciences Group, Inc. announced final follow-up data for its Phase I/II study of GPS in patients with AML in second complete remission. [SELLAS Life Sciences Group, Inc.] Press Release

Federal Judge Rules Clinical Trial Sponsors Must Publish a Decade’s Worth of Missing Data

For years, government research agencies have misinterpreted a law that requires them to collect and post clinical trial data, a federal judge ruled this week, leaving behind a 10-year gap in data that now must be made publicly available. [STAT News] Editorial

Contract Offers Unprecedented Look at Google Deal to Obtain Patient Data from the University of California

It was the fall of 2015 when researchers from Google and the University of California, San Francisco, first sat down together to hash out a research collaboration in an area that has since exploded with activity: using artificial intelligence to make predictions in the hospital. [STAT News] Editorial

White House Formally Invites Public Comment on Open-Access Policies

The White House issued a notice seeking comment on its effort to enhance public access to federally funded research. It’s an old idea creating new controversy. White House Office of Science and Technology Policy Director Kelvin Droegemeier is pushing back against publishers that in December said the administration was quietly pursuing an executive order to require immediate free distribution of taxpayer funded research. [ScienceInsider] Editorial

NEW International Society for Stem Cell Research (ISSCR) 2020 Annual Meeting
June 24-27, 2020
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scientist – Stem Cell Biology (Cancer Research UK Manchester Institute)

PhD Student Position – Oral Biology and Medicine (Karolinska Institutet)

Research Technician – Graft versus Host Disease (Fred Hutchinson Cancer Research Center)

Laboratory Director – Cord Blood Processing (PerkinElmer)

Research Associate – Cell Culture (Rogosin Institute)

Tenure-Track/Tenured Faculty Positions – Biomedical Science (Southern University of Science and Technology)

Postdoctoral Fellow Positions – Epigenetics, 3D Bioprinting, Hematopoietic Stem Cell Biology, Bioengineering, and Blood Cancers (Childrens Hospital & Ohio State University)

Assistant or Associate Professor – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

Senior Research Scientist – Stem Cell Biology and Disease Modeling (Tata Institute for Genetics and Society)

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