Cord Blood News Volume 12.11 | Mar 26 2020

TOP STORY

Nov/CCN3 Enhances Cord Blood Engraftment by Rapidly Recruiting Latent Human Stem Cell Activity

Researchers showed that brief incubation of umbilical cord blood CD34⁺ cells with the matricellular regulator Nov (CCN3) increased the frequency of serially transplantable hematopoietic stem cells six-fold. [Cell Stem Cell] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development

Scientists report that natural killer cell potential first arised from Hoxa^neg/low Kit⁺CD41⁺CD16/32⁺ hematopoietic-stem-cell-independent erythro-myeloid progenitors present in the murine yolk sac. [Dev Cell] Full Article | Graphical Abstract

CD133⁺ Exosome Treatment Improves Cardiac Function after Stroke in Type 2 Diabetic Mice

Investigators tested whether treatment with exosomes harvested from human umbilical cord blood derived CD133⁺ cells improved cardiac function in type 2 diabetes mellitus stroke mice. [Transl Stroke Res] Abstract

Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial

A randomized controlled Phase I/II clinical trial was designed to evaluate the safety and efficacy of encapsulated human umbilical cord MSCs in a plasma-derived biomaterial for regenerative endodontic procedures in mature permanent teeth with apical lesions. [J Dent Res] Abstract

Comparative Profiling of Exosomal miRNAs in Human Adult Peripheral and Umbilical Cord Blood Plasma by Deep Sequencing

A total of 65 exosomal miRNAs, including 46 upregulated and 19 downregulated, showed differential expression between umbilical cord blood and peripheral blood. Target genes of these miRNAs were mainly enriched in signaling pathways associated with pregnancy, cancers, cell mobility and nervous system. [Epigenomics] Abstract

Exosomes-Carried MicroRNA-26b-5p Regulates Microglia M1 Polarization after Cerebral Ischemia/Reperfusion

Ischemia/reperfusion (I/R) mouse model was established, and exosomes derived from human umbilical cord MSCs were isolated, identified, and injected to I/R mice to observe nerve injury and microglia M1 polarization. [Cell Cycle] Abstract

Combination of Haploidentical Hematopoietic Stem Cell Transplantation with an Unrelated Cord-Blood Unit in Patients with Severe Aplastic Anemia: A Report of 146 Cases

Investigators analyzed the outcomes of 146 severe aplastic anemia patients who received a combination of haploidentical hematopoietic stem cell transplantation and an unrelated cord-blood unit between September 2011 and December 2017. [Bone Marrow Transplant] Abstract

Mesenchymal Stromal Cell-Derived Exosomes Improve Pulmonary Hypertension through Inhibition of Pulmonary Vascular Remodeling

Exosomes derived from the supernatant of human umbilical cord MSCs were injected into monocrotaline-pulmonary hypertension model rat or added into the cells cultured medium. Immunohistochemistry, quantitative real-time polymerase chain reaction and western blot methods were used in vivo and in vitro. [Respir Res] Full Article

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Zika Virus and Its Implications on Cord Blood Banking and Transplantation

There is a crucial need for updated travel risk assessment for Zika virus transmission, validated screening tests for Zika virus in umbilical cord blood, and further research on Zika virus transmissibility due to umbilical cord blood products to ensure that umbilical cord blood and related tissues are safe and available for transplantation. [Transfusion] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Tolero Pharmaceuticals Joins The Leukemia & Lymphoma Society’s Groundbreaking Beat AML Master Clinical Trial for Patients with Acute Myeloid Leukemia

Tolero Pharmaceuticals, Inc. announced that it has joined The Leukemia & Lymphoma Society in the groundbreaking, collaborative Beat AML Master Clinical Trial for newly diagnosed patients 60 years of age or older with acute myeloid leukemia (AML). [Tolero Pharmaceuticals, Inc. (PR Newswire Association LLC.)] Press Release

Ascentage Pharma Announces First Patient Dosed in the Global Phase Ib/II Clinical Study of Bcl-2 Inhibitor APG-2575 in the United States

Ascentage Pharma announced that the global Phase Ib/II clinical study of APG-2575, a Bcl-2 selective inhibitor, as a single agent or in combination for the treatment of relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma, has dosed its first patient in the United States. [Ascentage Pharma] Press Release

Do Preprints Improve with Peer Review? A Little, One Study Suggests

Every day, scientists post dozens of preprints—studies that have not been peer reviewed—on public servers such as bioRxiv. Preprints allow scientists access to cutting-edge findings faster than when authors submit their findings to traditional journals, which often take months to complete reviews. [ScienceInsider] Editorial

Researchers Are Tracking Another Epidemic, Too—of Misinformation

When five researchers at the University of Washington, Seattle, launched the new Center for an Informed Public back in December 2019, they had no idea what was coming. The center aims to study how misinformation propagates and use the findings to “promote an informed society, and strengthen democratic discourse. Now, just a few months later, the coronavirus pandemic is generating a tidal wave of information—some of it accurate, some not so much—that has saturated social and traditional media.” [ScienceInsider] Editorial

COVID-19: Biomedical Research in a World under Social-Distancing Measures

Cancelled conferences and overpriced consumables: how can biomedical research function when the lab is out of reach? [Nature News] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

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NEW Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Researcher – Hematologic Malignancies (Northwestern University)

Postdoctoral Position – Hematopoietic Stem Cell Biology (Columbia University Medical Center)

Postdoctoral Positions – Cancer Research (Moores Cancer Center, UC San Diego)

Team Leader – Clonal Evolution in Leukemias (Institute of Cancer Research)

Postdoctoral Researcher – Leukemia (Universitätsklinikum Carl Gustav Carus Dresden)

Postdoctoral Scientist – Stem Cell Biology (Cancer Research UK Manchester Institute)

Research Technician – Graft versus Host Disease (Fred Hutchinson Cancer Research Center)

Laboratory Director – Cord Blood Processing (PerkinElmer)

Tenure-Track/Tenured Faculty Positions – Biomedical Science (Southern University of Science and Technology)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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