Cord Blood News Volume 12.24 | June 25 2020

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    Justin.choi
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    2020-06-25 | CBN 12.24

    Cord Blood News by STEMCELL Technologies
    Vol. 12.24 – 25 June, 2020
    TOP STORY

    Engraftment Kinetics after Transplantation of Double Unit Cord Blood Grafts Combined with Haplo-Identical CD34+ Cells without Antithymocyte Globulin

    Scientists investigated adding haplo-identical CD34+ cells to double unit cord blood (CB) grafts to facilitate early haplo-identical donor-derived neutrophil recovery prior to CB engraftment.
    [Leukemia]
    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    A Scaffold Laden with Mesenchymal Stem Cell-Derived Exosomes for Promoting Endometrium Regeneration and Fertility Restoration through Macrophage Immunomodulation

    A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
    [Acta Biomaterialia]
    Abstract

    A Circular RNA Map for Human Induced Pluripotent Stem Cells of Fetal Origin

    Reprogramming was achieved by a footprint-free strategy. Self-renewal and pluripotency of cord blood MSC-human induced pluripotent stem cells (hiPSC) were investigated in vitro and in vivo, compared to parental MSC, to embryonic stem cells and to fibroblast derived-hiPSC.
    [Ebiomedicine]
    Full Article

    Enhanced Collection of Phenotypic and Engrafting Human Cord Blood Hematopoietic Stem Cells at 4°C

    Researchers demonstrated that collecting and processing of human cord blood at 4°C within minutes of the baby’s birth results in significantly enhanced numbers of rigorously defined phenotypic hematopoietic stem cell and self‐renewing NSG immune‐deficient mouse engrafting and SCID‐repopulating cells.
    [Stem Cells]
    Abstract

    Nanospheres Loaded with Curcumin Improve the Bioactivity of Umbilical Cord Blood-Mesenchymal Stem Cells via c-Src Activation during the Skin Wound Healing Process

    Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human MSCs during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
    [Cells]
    AbstractDownload Full ArticleGraphical Abstract

    Effect of Amniotic Fluid Stem Cell Transplantation on the Recovery of Bladder Dysfunction in Spinal Cord-Injured Rats

    The effects of human amniotic fluid stem cell transplantation on bladder function and molecular changes in spinal cord-injured rats were investigated.
    [Scientific Reports]
    Full Article

    Ursodeoxycholic Acid Improves Feto-Placental and Offspring Metabolic Outcomes in Hypercholanemic Pregnancy

    Researchers analyzed the lipid profile of fetal serum from untreated intrahepatic cholestasis of pregnancy (ICP), ursodeoxycholic acid (UDCA)-treated ICP and uncomplicated pregnancies and found that UDCA ameliorated ICP-associated fetal dyslipidemia.
    [Scientific Reports]
    Full Article

    A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice

    Researchers investigated the anti-fibrotic activity of a flowable placental formulation using a bleomycin-induced dermal fibrosis model in aged mice.
    [European Journal of Human Genetics]
    Full Article
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    REVIEWS

    Regenerative Potential of Wharton’s Jelly-Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

    The authors summarize the current pre-clinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
    [Journal of Cellular Physiology]
    Abstract
    INDUSTRY AND POLICY NEWS

    Gender Gap in Research Output Widens During Pandemic

    A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
    [The Scientist]
    Editorial

    Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

    Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
    [ScienceInsider]
    Editorial

    COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

    Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
    [ScienceInsider]
    Editorial
    FEATURED EVENT

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    JOB OPPORTUNITIES

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