Cord Blood News Volume 12.26 | July 9 2020

    0
    97







    CBN 12.25 | July 9


    Cord Blood News by STEMCELL Technologies
    Vol. 12.25 – 9 July, 2020
    TOP STORY

    Regulatory T Cells for Treating Patients with COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports

    Physician-investigators at Johns Hopkins University Hospital report on the promising data of treatment of COVID-19 induced acute respiratory distress syndrome with allogeneic, cord blood derived T-regulatory cell therapy.
    [Annals of Internal Medicine]

    Full ArticlePress Release

    Subscribe to Science News for free weekly science newsletters.
    PUBLICATIONSRanked by the impact factor of the journal

    The BET Inhibitor CPI203 Promotes Ex Vivo Expansion of Cord Blood Long-Term Repopulating HSCs and Megakaryocytes

    Of ten compounds tested, only the Bromodomain and Extra-terminal Motif inhibitor CPI203 enhanced the expansion of human cord blood hematopoietic stem cells without losing cell viability in vitro.
    [Blood]

    Abstract

    LOXL2 from Human Amniotic Mesenchymal Stem Cells Accelerates Wound Epithelialization by Promoting Differentiation and Migration of Keratinocytes

    Investigators observed increased migration and reduced proliferation and differentiation when keratinocytes were co-cultured in media conditioned by human amniotic epithelial cells and human amniotic mesenchymal stem cells.
    [Aging-Us]

    Full Article

    Coinhibition of Activated p38 MAPKα and mTORC1 Potentiates Stemness Maintenance of HSCs from SR1 -Expanded Human Cord Blood CD34+ Cells via Inhibition of Senescence

    Researchers showed that cellular senescence occurred in the Stem Regenin 1‐expanded hUCB CD34+ cells in which p38 mitogen‐activated protein kinase α (p38α) and mammalian target of rapamycin complex 1 (mTORC1) were successively activated.
    [Stem Cells Translational Medicine]

    Full Article

    Control the Fate of Human Umbilical Cord Mesenchymal Stem Cells with Dual-Enzymatically Cross-Linked Gelatin Hydrogels for Potential Applications in Nerve Regeneration

    Scientists proposed a new dual‐enzymatically cross‐linked and injectable gelatin hydrogel for regulating survival, proliferation and differentiation of human umbilical cord mesenchymal stem cells in three‐dimensional matrix.
    [Journal of Tissue Engineering and Regenerative Medicine]

    Abstract

    Tissues Derived from Reprogrammed Wharton’s Jelly Stem Cells of the Umbilical Cord as a Platform to Study Gestational Diabetes Mellitus

    Investigators reprogrammed the stem cells from the Wharton’s jelly of umbilical cords of gestational diabetes mellitus (GDM) and non-GDM mothers into induced pluripotent stem cells and then differentiated the iPSCs into insulin-producing cells to provide pancreatic tissues that represent the fetus of GDM and normal mothers.
    [Stem Cell Research]

    Full Article

    Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Cutaneous Wound Healing by Enhancing Angiogenesis through Delivering Angiopoietin-2

    Researchers found that human umbilical MSC-exosomes accelerated skin wound healing and angiogenesis, inducing a higher wound-closure rate and increased expression of CD31 in vivo.
    [Stem Cell Reviews and Reports]

    Abstract

    Static Magnetic Field–Enhanced Osteogenic Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells via Matrix Vesicle Secretion

    Wharton’s jelly mesenchymal stem cells were treated with a 0.4-T static magnetic field. The cell viability was tested using the MTT assay.
    [International Journal of Radiation Biology]

    Abstract

    Watch 'collaborating to accelerate COVID-19 research'
    REVIEWS

    Umbilical Cord Blood: The Promise and the Uncertainty

    Umbilical cord blood is readily available, has low immunogenicity, and does not require as strict of human leukocyte antigen matching compared to other graft sources.
    [Stem Cells Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    ‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

    A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
    [Science]

    Editorial

    An Optimist Takes the Helm at the National Science Foundation

    The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists—who make up a sizeable share of the U.S. research enterprise—to enter the country.
    [Science]

    Editorial

    FEATURED EVENT

    The New York Stem Cell Foundation (NYSCF) Conference

    October 20 – October 21
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Laboratory Manager – Hematopoietic Stem Cells

    University of Pennsylvania Health System – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Pluripotent Stem Cell Biology and Cardiac Disease Modeling

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Position – Immune Privilege of the Stem Cell Niche

    Columbia University – New York, New York, United States

    Research Technician – Cord Blood Preparation

    Duke University – Durham, North Carolina, United States

    Instructor – Stem Cell Products

    University of Colorado – Denver, Colorado, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cord Blood News Twitter