Cord Blood News Volume 12.29 | Jul 30 2020

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    2020-07-30 | CBN 12.28


    Cord Blood News by STEMCELL Technologies
    Vol. 12.28 – 30 July, 2020
    TOP STORY

    Neonatal Genetics of Gene Expression Reveal Potential Origins of Autoimmune and Allergic Disease Risk

    Investigators mapped expression quantitative trait loci in resting myeloid cells and CD4+ T cells from cord blood samples, as well as in response to lipopolysaccharide or phytohemagglutinin stimulation, respectively.
    [Nature Communications]

    Full Article

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury

    Researchers report serial changes in six circulating, cross-species/bridging biomarkers in a clinically relevant porcine model of neonatal hypoxic ischemic encephalopathy with functional analysis.
    [Molecular Neurobiology]

    Full Article

    Comparison of Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Isolated from Cryopreserved Material and Extracted by Explantation and Digestion Methods Utilizing a Split Manufacturing Model

    Umbilical cord (UC)-derived MSCs were isolated from 10 UC tissue samples by both explantation and enzymatic digestion methods to allow for comparison of cells from the same donor.
    [Cytotherapy]

    Full Article

    Effects of Conditioned Medium from Bone Marrow Cells on Human Umbilical Cord Perivascular Cells

    Investigators evaluated the effects of human bone marrow (hBM)-conditioned medium derived from different stages of hBM MSC culture on the osteogenic capacity of perivascular tissue of the human umbilical cord.
    [Tissue Engineering]

    Abstract

    Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells Maintains and Partially Improves Visual Function in Patients with Advanced Retinitis Pigmentosa

    The authors conducted a Phase I/II clinical trial aiming to evaluate the safety and efficacy of intravenous administration of umbilical cord MSCs in advanced retinitis pigmentosa patients.
    [Stem Cells and Development]

    Abstract

    Combined Use of Recombinant Human Bone Morphogenetic Protein-7 and Osteogenic Media May Have No Ideal Synergistic Effect on Bone Regeneration of Human Umbilical Cord Mesenchymal Stem Cells Seeded on Nano-Hydroxyapatite/Collagen/Poly (L-Lactide)

    Scientists investigated the effect of recombinant human bone morphogenetic protein-7 and/or osteogenic media on bone regeneration of human umbilical cord-MSCs seeded on nano-hydroxyapatite/collagen/poly (L-lactide) in a rabbit model.
    [Stem Cells and Development]

    Abstract

    Donor Stem Cell-Derived Paroxysmal Nocturnal Hemoglobinuria after Umbilical Cord Blood Transplantation

    The authors report a patient with adult T‐cell leukemia/lymphoma, who developed paroxysmal nocturnal hemoglobinuria seven years after umbilical cord blood transplantation.
    [European Journal of Haematology]

    Abstract

    MSCs-Released TGFβ1 Generate CD4+CD25+Foxp3+ in T-Reg Cells of Human SLE PBMC

    The authors used a post-test control group design. MSCs were obtained from human umbilical cord blood and characterized according to their surface antigen expression and multilineage differentiation capacities.
    [Journal of the Formosan Medical Association]

    Full Article

    Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats

    Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
    [Neuroscience Research]

    Full Article

    Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions.
    REVIEWS

    Hematopoietic Stem Cells from Pluripotent Stem Cells: Clinical Potential, Challenges, and Future Perspectives

    Ex vivo hematopoietic stem cell derivation from renewable sources such as induced pluripotent stem cells offers an experimental tool for studying developmental hematopoiesis, disease modeling, and drug discovery, and yields tremendous therapeutic potential for malignant and nonmalignant hematological disorders.
    [Stem Cells Translational Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    ‘Vaccine Nationalism’ Threatens Global Plan to Distribute COVID-19 Shots Fairly

    As soon as the first COVID-19 vaccines get approved, a staggering global need will confront limited supplies. Many health experts say it’s clear who should get the first shots: health care workers around the world, then people at a higher risk of severe disease, then those in areas where the disease is spreading rapidly, and finally, the rest of us.
    [ScienceInsider]

    Editorial

    The Trump Administration Must Stop Sidelining the CDC

    As deaths from COVID-19 approach 150,000 in the United States and cases continue to rise alarmingly in many regions of the country, there are strong signs that the government is suppressing a public-health approach to controlling the pandemic.
    [Nature News]

    Editorial

    FEATURED EVENT

    53rd Annual Meeting Society for Leukocyte Biology

    September 30 – October 3
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Position – iPSCs and Endothelial Cells

    Huntington Medical Research Institutes – Pasadena, California, United States

    Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Researcher – Red Blood Cell Signaling and Physiology

    University of Maryland – Baltimore, Maryland, United States

    Postdoctoral Fellow – Pluripotent Stem Cell Biology and Cardiac Disease Modeling

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Position – Immune Privilege of the Stem Cell Niche

    Columbia University – New York, New York, United States

    > See All Jobs

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