Cord Blood News Volume 12.30 | Aug 6 2020

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    CBN 12.29 | Volume 12.29


    Cord Blood News by STEMCELL Technologies
    Vol. 12.29 – 6 August, 2020
    TOP STORY

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

    Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
    [Stem Cell Research & Therapy]

    Full Article
    {5128561b-dd1e-4f6c-84a7-2ff15dd0257d}_ON829HSC-Jen-Adair-EP-Podcast-645x110
    PUBLICATIONSRanked by the impact factor of the journal

    The Impact of Donor Type on the Outcome of Pediatric Patients with Very High Risk Acute Lymphoblastic Leukemia: A Study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG

    Two consecutive international prospective studies, ALL- stem cell transplantation (SCT)-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with very high risk disease leading to any kind of hematopoietic SCT.
    [Bone Marrow Transplantation]

    Full Article

    Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation for Mature T- and NK-Cell Neoplasms in the Kyoto Stem Cell Transplantation Group

    39 patients received bone marrow or peripheral blood stem cell transplantation (PBSCT) from related donors, 37 received BMT/PBSCT from unrelated donors, and 35 received cord blood transplantation
    [Biology of Blood and Marrow Transplantation]

    Abstract

    A Phase I Study to Evaluate Two Doses of Wharton’s Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease

    A two-dose cohort trial allogeneic Wharton’s Jelly-derived mesenchymal stromal cells were tested in ten patients with de novo high risk or steroid refractory acute graft versus host disease post allogeneic hematopoietic stem cell transplantation.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study

    67 patients were treated with Wharton’s jelly mesenchymal stem cells. The treated patients were paired with 67 reference patients from the PRO-ACT database which contains patient records from 23 amyotrophic lateral sclerosis clinical studies
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Short-Term Exposure of Umbilical Cord Blood CD34+ Cells to Human Platelet Lysate and Cytokines Enhances Engraftment

    Hematopoietic progenitor stem cells (HSPCs) were isolated from human umbilical cord blood. HSPC were seeded in the wells of a 24‐well microplate and exposed to increasing concentrations of human platelet lysates with or without cytokines for 24 hours.
    [Transfusion]

    Abstract

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    REVIEWS

    Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review

    The authors systematically review literature pertaining to hematopoietic stem cell (HSC) based tissue engineering strategies in animal models of chondral repair such that trends may be identified and the utility of HSCs in chondral repair can be elucidated
    [Tissue Engineering]

    Abstract

    INDUSTRY AND POLICY NEWS

    IMAC Holdings Receives FDA Authorization to Initiate Clinical Study of Its Umbilical Cord-Derived Allogenic Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

    IMAC Holdings, Inc. announced FDA approved its investigational new drug application, which IMAC submitted in May 2020, for the use of umbilical cord-derived allogenic mesenchymal stem cells for the treatment of bradykinesia, or the gradual loss and slowing down of spontaneous body movement, due to Parkinson’s disease.
    [IMAC Holdings, Inc. (GlobeNewswire, Inc.) ]

    Press Release

    Anti-Abortion Ethicists and Scientists Dominate Trump’s Fetal Tissue Review Board

    Research advocates were eager to learn who Health and Human Services Secretary Alex Azar would appoint to the board and to see its ideological makeup. On July 31st they got their first look as it gathered online for a one-time meeting run by the National Institutes of Health.
    [ScienceInsider]

    Editorial

    FEATURED EVENT

    Till & McCulloch Meetings 2020

    October 26 – October 28
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Associated – NOTCH1- Mediated Leukemogenesis

    University of Massachusetts – Amherst, Massachusetts, United States

    Postdoctoral Position – iPSCs and Endothelial Cells

    Huntington Medical Research Institutes – Pasadena, California, United States

    Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Researcher – Red Blood Cell Signaling and Physiology

    University of Maryland – Baltimore, Maryland, United States

    Postdoctoral Fellow – Pluripotent Stem Cell Biology and Cardiac Disease Modeling

    Northwestern University – Chicago, Illinois, United States

    > See All Jobs

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