Cord Blood News Volume 12.38 | Oct 1 2020

May 12, 2022

100

2020-10-01 | CBN 12.37

Cord Blood News by STEMCELL Technologies

Vol. 12.38 – 1 October, 2020

TOP STORY

Human
Placental MSC-Secreted IL-1β Enhances Neutrophil Bactericidal Functions during Hypervirulent Klebsiella Infection

Investigators assessed whether multilineage MSCs, best known for immunomodulation toward T cells, could be therapeutic for highly virulent bacterial infections via modulation of polymorphonuclear neutrophils.
[Cell Reports]

Full Article Graphical Abstract

Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.

PUBLICATIONSRanked by the impact factor of the journal

Effects
of Degradable Magnesium on Paracrine Signaling between Human Umbilical Cord Perivascular Cells and Peripheral Blood Mononuclear Cells

The proliferation and viability of both cell types were not significantly influenced by magnesium (Mg). When human umbilical cord perivascular cells were cultured with degradable Mg, a moderate inflammation, and an increased pro-healing M2 macrophage phenotype were observed.
[Biomaterials Science]

Full Article Graphical
Abstract

Intracerebral
Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model

Researchers compared the therapeutic effects of various delivery routes when administering Good Manufacturing Practice-grade human umbilical cord-MSCs in a rodent model of subacute-phase stroke.
[Frontiers in Cellular Neuroscience]

Full Article

Clinical
Effects of Intrathecal Administration of Expanded Wharton Jelly Mesenchymal Stromal Cells in Patients with Chronic Complete Spinal Cord Injury: A Randomized Controlled Study

Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton’s jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
[Cytotherapy]

Abstract

Ethionamide
Preconditioning Enhances the Proliferation and Migration of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

Preconditioning with ethionamide promoted the proliferation of Wharton’s jelly-derived MSCs by activating phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase/extracellular signal-regulated kinase 1/2 signaling.
[International Journal of Molecular Sciences]

Full Article

Characterization
of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering

Different scaffold configurations were characterized in terms of morphology and a mechanical response, and their interactions with two types of stem cells and bone marrow MSCs were assessed.
[Polymers]

Full Article

Exosomes
Derived from Human Placenta-Derived Mesenchymal Stem Cells Improve Neurologic Function by Promoting Angiogenesis after Spinal Cord Injury

The human placenta-derived (hP) MSCs-derived exosomes were extracted using a sequential centrifugation approach. Then, the effects of hPMSCs-Exos on angiogenesis were analysis both in vitro and in vivo. In addition, the sensory and locomotor functions of mice after spinal cord injury were also analyzed.
[Neuroscience Letters]

Abstract

Learn about the applications of the CFU assay in toxicity testing from hematopoietic expert Dr. Jackie Damen.

REVIEWS

Expansion
of Human Mesenchymal Stem/Stromal Cells (hMSCs) in Bioreactors Using Microcarriers: Lessons Learnt and What the Future Holds

The authors examine the various factors to be considered when developing a humsn MSC manufacturing process using microcarriers and bioreactors and their potential impact on the final product.
[Biotechnology Advances]

Abstract

Differentiation
of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

Scientists summarize the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy.
[Stem Cell Reviews and Reports]

Full Article Graphical Abstract

INDUSTRY AND POLICY NEWS

Stem
Cells Offer New Glimpse at How the Placenta Emerges—and How the Fetus-Sustaining Organ Can Fail

Researchers have devised a way to derive and observe early precursors of placental cells in a dish. They have found a method of “reprogramming” adult cells, reverting them to a primitive state, that can prompt them to become trophoblast stem cells, which give rise to placental cells.
[ScienceInsider]

Press Release

OrganaBio
Launches Portfolio of Novel Perinatal Tissue-Derived Products to Spur Rapid Development of Cell and Gene Therapies

OrganaBio, LLC announced the launch of the MesenPAC™-MSC platform (comprised of placenta- and umbilical cord-derived mesenchymal stem/stromal cells) and ImmunoPAC™ product lines, designed to support translational researchers in their quest to rapidly develop next generation cell-based therapies. These products provide a unique and timely solution to critical supply chain issues that are hindering the regenerative medicine, cell therapy, gene therapy, and immunotherapy arenas.
[OrganaBio, LLC (Businesswire, Inc.)]

Press Release

Avalon GloboCare Provides Clinical Updates on Its CAR-T Immuno-Oncology and Allogeneic Mesenchymal Stromal Cell (MSC) Therapy Programs Following Successful Completion of Phase I AVA-001 Clinical Trial

Avalon GloboCare Corp. provided a clinical update on its chimeric antigen receptor (CAR) T-cell therapy and allogeneic mesenchymal stromal cell (MSC) therapy programs following successful completion of its Phase I clinical trial of AVA-001, the company’s leading CAR T-cell therapy candidate in development for patients with relapsed/refractory B-cell lymphoblastic leukemia.
[Avalon GloboCare Corp. (GlobeNewswire, Inc.)]

Press Release

FEATURED EVENT

Human
Placental MSC-Secreted IL-1β Enhances Neutrophil Bactericidal Functions during Hypervirulent Klebsiella Infection

Effects
of Degradable Magnesium on Paracrine Signaling between Human Umbilical Cord Perivascular Cells and Peripheral Blood Mononuclear Cells

Intracerebral
Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model

Clinical
Effects of Intrathecal Administration of Expanded Wharton Jelly Mesenchymal Stromal Cells in Patients with Chronic Complete Spinal Cord Injury: A Randomized Controlled Study

Ethionamide
Preconditioning Enhances the Proliferation and Migration of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

Characterization
of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering

Exosomes
Derived from Human Placenta-Derived Mesenchymal Stem Cells Improve Neurologic Function by Promoting Angiogenesis after Spinal Cord Injury

Expansion
of Human Mesenchymal Stem/Stromal Cells (hMSCs) in Bioreactors Using Microcarriers: Lessons Learnt and What the Future Holds

Differentiation
of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

Stem
Cells Offer New Glimpse at How the Placenta Emerges—and How the Fetus-Sustaining Organ Can Fail

OrganaBio
Launches Portfolio of Novel Perinatal Tissue-Derived Products to Spur Rapid Development of Cell and Gene Therapies

Avalon GloboCare Provides Clinical Updates on Its CAR-T Immuno-Oncology and Allogeneic Mesenchymal Stromal Cell (MSC) Therapy Programs Following Successful Completion of Phase I AVA-001 Clinical Trial

Keystone Symposia: Hematopoiesis

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Faculty Position – Stem Cell Biology

Faculty Member – Cellular, Developmental, and Stem Cell Biology

Research Associate – Stem Cell Differentiation and Cancer Initiation

Postdoctoral
/ PhD Student – Placental Vascular Immune Response

Postdoctoral Associate – NOTCH1- Mediated Leukemogenesis

> See All Jobs