Cord Blood News Volume 13.01 | Jan 14 2021

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    2020-01-14 | CBN 12.01


    Cord Blood News by STEMCELL Technologies
    Vol. 12.01 – 14 January, 2021
    TOP STORY

    Single-Cell
    Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells

    Scientists combined bulk and single-cell transcriptional profiling of lymphoid cells, myeloid cells, and hematopoietic stem-progenitor cells from fetal, perinatal, and adult developmental stages to demonstrate that the fetal-to-adult transition occurred progressively along a continuum of maturity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    The StemSpanâ„¢ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell
    Transcriptome Analysis of Uncultured Human Umbilical Cord Mesenchymal Stem Cells

    Researchers investigated freshly isolated, uncultured umbilical cord (UC)-MSCs by single-cell RNA sequencing and found two populations of UC-MSCs.
    [Stem Cell Research & Therapy]

    Full Article

    Human
    Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-27b Attenuates Subretinal Fibrosis via Suppressing Epithelial–Mesenchymal Transition by Targeting HOXC6

    Human umbilical cord-derived MSCs were successfully cultured and identified, and exosomes were isolated from the supernatant by ultracentrifugation.
    [Stem Cell Research & Therapy]

    Full Article

    Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro

    Scientists stimulated freshly isolated umbilical blood mononuclear cells with lysates of E. faecalis, S. agalacticae, and S. aureus collected from pregnant women in preterm labor.
    [International Journal of Molecular Sciences]

    Full Article

    Amniotic
    Fluid-Derived Multipotent Stromal Cells Drive Diabetic Wound Healing through Modulation of Macrophages

    Researchers obtained third trimester amniotic fluid from term cesarean delivery and isolated and expanded MSCs in vitro. They then generated ten mm wounds in Leprdb/db diabetic mouse skin, and splinted them open to allow for humanized wound modeling.
    [Journal of Translational Medicine]

    Full Article

    Hypoxia-Induced
    Amniotic Fluid Stem Cell Secretome Augments Cardiomyocyte Proliferation and Enhances Cardioprotective Effects under Hypoxic-Ischemic Conditions

    The authors hypothesized that modulation of oxygen conditions during uman amniotic fluid stem cell generation enriches soluble bioactive factors and confers enhanced regenerative and cardioprotective effects on cardiovascular cells.
    [Scientific Reports]

    Full Article

    Impact
    of Placental Malaria on Maternal, Placental and Fetal Cord Responses and Its Role in Pregnancy Outcomes in Women from Blue Nile State, Sudan

    Malaria infection in the collected maternal peripheral, placental, umbilical cord samples was determined microscopically, and ELISA was used to measure the plasma levels IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples.
    [Malaria Journal]

    Full Article

    Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions.
    REVIEWS

    Great Expectations: Induced Pluripotent Stem Cell Technologies in Neurodevelopmental Impairments

    Investigators introduce the development of induced pluripotent stem cells (iPSCs), the currently established iPSC disease models, and artificial organoids related to neurodevelopmental impairments.
    [International Journal of Medical Sciences]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bone Therapeutics Treats First Patient in ALLOB Phase IIb Tibial Fracture Study

    Bone Therapeutics announced it has treated the first patient for the ALLOB Phase IIb clinical study in patients with difficult-to-heal tibial fractures. The successful completion of Bone Therapeutics’ ALLOB trials would further demonstrate the promise of mesenchymal stromal derived cell therapies for the treatment of other underserved conditions.
    [Bone Therapeutics SA]

    Press Release
    FEATURED EVENT

    The European Society for Blood and Marrow Transplantation

    March 14 – 17, 2021
    Virtual


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    Fondazione Human Technopole – Milan, Italy

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    Columbia University Medical Center – New York, New York, United States


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    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

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