Cord Blood News Volume 13.10 | Mar 18 2021

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    2021-03-18 | CBN 13.10


    Cord Blood News by STEMCELL Technologies
    Vol. 13.10 – 18 March, 2021
    TOP STORY

    Amniotic Membrane-Mesenchymal Stromal Cells Secreted Factors and Extracellular Vesicle-miRNAs: Anti-Inflammatory and Regenerative Features for Musculoskeletal Tissues

    37 cytokines/chemokines were identified at varying abundance, some of which involved in both chemotaxis and homeostasis of inflammatory cells and in positive remodeling of extracellular matrix, often damaged in tendinopathy and osteoarthritis.
    [Stem Cells Translational Medicine]

    Full Article
    Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    hiPSC-Derived NSCs Effectively Promote the Functional Recovery of Acute Spinal Cord Injury in Mice

    The authors investigated the effect of human induced pluripotent stem cell-derived neural stem cells and umbilical cord-derived MSCs in a mouse model of acute spinal cord injury.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    Umbilical Cord-Derived Mesenchymal Stromal Cells Immunomodulate and Restore Actin Dynamics and Phagocytosis of LPS-Activated Microglia via PI3K/Akt/Rho GTPase Pathway

    Researchers elucidated whether human umbilical cord-derived MSCs can exert immunomodulatory effect and change the phenotype of activated microglia.
    [Cell Death Discovery]

    Full Article

    Pre-Conditioning of Mesenchymal Stem Cells with Piper longum L. Augments Osteogenic Differentiation

    Proliferation of Wharton’s jelly MSCs treated with Piper longum L. fruit extract was assessed by MTT assay and Cell Cycle Analysis. Effect of Piper longum L. preconditioning on osteogenic differentiation was performed.
    [Journal of Ethnopharmacology]

    Abstract

    Conditioned Media Derived from Mesenchymal Stem Cells Induces Apoptosis and Decreases Cell Viability and Proliferation in Squamous Carcinoma Cell Lines

    Scientists evaluated the effects of cultured media-MSCs on proliferation and apoptosis of CAL-27 and FaDu squamous cell carcinoma cell lines.
    [Gene]

    Abstract

    In Vitro Activation and Development of Goat Preantral Follicles Enclosed in Ovarian Tissue Co-Cultured with Mesenchymal Stem Cells

    The authors investigated the use of caprine Wharton’s Jelly MSCs on the survival and in vitro development of goat preantral follicles enclosed in ovarian fragments cultured for one or seven days.
    [Reproductive Sciences]

    Abstract

    The Therapeutic Potential of Amniotic Fluid-Derived Stem Cells on Busulfan-Induced Azoospermia in Adult Rats

    Researchers explored the possible therapeutic role of amniotic fluid-derived stem cells in improving busulfan-induced azoospermia in adult rats.
    [Tissue Engineering and Regenerative Medicine]

    Abstract
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    REVIEWS

    The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy

    MSCs currently constitute the most frequently used cell type in advanced therapies with different purposes, most of which are related with inflammatory processes.
    [Frontiers in Cell and Developmental Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Celularity Announces Fast Track Designation by the FDA for its Natural Killer Cell Therapy CYNK-001 in the Treatment of Recurrent Glioblastoma Multiforme

    Celularity Inc. announced that the company has received Fast Track Designation from the FDA for its non-genetically modified cryopreserved human placental hematopoietic stem cell-derived natural killer cell therapy, CYNK-001, for the treatment of adults with recurrent glioblastoma multiforme.
    [Celularity, Inc.]

    Press Release

    S. Korean Govt. Initiates W600b Program to Nurture Regenerative Medicine

    The South Korean government announced that it would spend 595 billion won ($525.6 million) by 2030 to support the country’s regenerative medicine sector.
    [The Korea Herald]

    Press Release
    FEATURED EVENT

    ISSCR: Stem Cells and Regenerative Medicine

    January 12 – 14, 2022
    Shanghai, China

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    JOB OPPORTUNITIES

    Stem Cell Core Director – Stem Cell Research

    Gladstone Institute – San Francisco, California, United States

    Lab Scientist – Tissue and Cellular Therapy

    The University of Iowa – Iowa City, Iowa, United States

    Associate Researcher – Umbilical Cord Blood Therapeutics

    Cleveland Cord Blood Center – Cleveland, Ohio, United States

    Senior Scientist – Assay Development

    CyberCoders – San Diego, California, United States

    Postdoctoral Position – Hematopoietic Development

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

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