Cord Blood News Volume 13.11 | Apr 1 2021

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    2020-04-01 | CBN 13.11


    Cord Blood News by STEMCELL Technologies
    Vol. 13.11 – 1 April, 2021
    TOP STORY

    Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Attenuate the Inflammation of Severe Steroid-Resistant Asthma by Reshaping Macrophage Polarization

    Investigators evaluated the effects of MSC-exosomes on airway hyper responsiveness, inflammation, histopathology, and macrophage polarization in severe, steroid-resistant asthma in mice.
    [Stem Cell Research & Therapy]

    Full Article
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Transcriptome Profiling Reveals Molecular Heterogeneity in Human Umbilical Cord Tissue and Culture-Expanded Mesenchymal Stem Cells

    The heterogeneity and the characteristics of cultured umbilical cord MSCs and the cognate human umbilical cord tissue at single‐cell resolution remains poorly defined.
    [FEBS Journal]

    Abstract

    NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair

    In vitro, nerve growth factor significantly improved the proliferation of human umbilical cord MSCs and mitigated cytotoxicity and apoptosis under hypoxic injury.
    [American Journal of Physiology-Heart and Circulatory Physiology]

    Abstract

    Beneficial Effects of Human Umbilical Cord Blood Mononuclear Cells on Persistent Erectile Dysfunction after Treatment of 5-Alpha Reductase Inhibitor in Rats

    In vivo erectile function, in vitro relaxant and contractile responses of CC, protein expression and localization of PDE5, eNOS, nNOS, HIF-1α, and smooth muscle content in penile tissue.
    [Journal of Sexual Medicine]

    Abstract

    A Composite Scaffold of Wharton’s Jelly and Chondroitin Sulphate Loaded with Human Umbilical Cord Mesenchymal Stem Cells Repairs Articular Cartilage Defects in Rat Knee

    In vitro experiments involved identification of the human umbilical cord MSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of Wharton’s jelly (WJ) and chondroitin sulfate, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold.
    [Journal of Materials Science-Materials in Medicine]

    Full Article

    Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

    Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
    [Cancer Biotherapy and Radiopharmaceuticals]

    Abstract

    Post-Transplant Food Anaphylaxis in an Adult Cord Blood Transplant Recipient (Ms. No. IJHM-D-20-01037R1)

    Scientists describe a case of new-onset food anaphylaxis after cord blood transplantation (CBT) in an adult patient that demonstrated that post-CBT allergen-challenge was not a risk for long-term allergic sensitization, even in adult recipients.
    [International Journal of Hematology]

    Abstract

    Explore scientific events this April with the Science Events Calendar.
    REVIEWS

    Stem Cell-Based Approaches in Cardiac Tissue Engineering: Controlling the Microenvironment for Autologous Cells

    The authors provide a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Sorrento Announces Updated Positive Results of Phase Ib Study of COVI-MSC™ for Treatment of ICU COVID-19 Patients

    Sorrento Therapeutics, Inc. announced updated positive results from its Phase Ib study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress (ARD) or acute respiratory distress syndrome (ARDS).
    [Sorrento Therapeutics, Inc. ]

    Press Release

    FUJIFILM Cellular Dynamics and Sana Biotechnology Announce License Agreement for the Development of iPSC-Derived Cell Therapies

    FUJIFILM Cellular Dynamics, Inc. and Sana Biotechnology, Inc. announced that Sana has been granted a non-exclusive right to use FUJIFILM Cellular Dynamics’ iPSC platform for the development of commercial cell therapies.
    [FUJIFILM Cellular Dynamics, Inc.]

    Press Release
    FEATURED EVENT

    6th Annual Arizona Cord Blood Conference: Bridging the Gap

    April 22, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Journal Editor – Blood Cancer Discovery and Cancer Immunology

    American Association for Cancer Research – Boston, Massachusetts, United States

    Postdoctoral Fellow – Myeloma Tumor Microenvironment

    Moores Cancer Center – La Jolla, California, United States

    Assistant Professor – Hematology

    University of Washington – Seattle, Washington, United States

    Lab Scientist – Tissue and Cellular Therapy

    The University of Iowa – Iowa City, Iowa, United States

    Senior Scientist – Assay Development

    CyberCoders – San Diego, California, United States

    > See All Jobs

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