Cord Blood News Volume 13.12 | Apr 8 2021

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    Justin.choi
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    2021-04-08 | CBN 13.12


    Cord Blood News by STEMCELL Technologies
    Vol. 13.12 – 8 April, 2021

    Systemic Administration of Mesenchymal Stem Cells Loaded with a Novel Oncolytic Adenovirus Carrying IL-24/Endostatin Enhances Glioma Therapy

    Investigators developed an all-in-one Tet-on system that could regulate replication of oncolytic adenovirus.
    [Cancer Letters]

    Abstract
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    Eradication of Specific Donor-Dependent Variations of Mesenchymal Stem Cells in Immunomodulation to Enhance Therapeutic Values

    Researchers analyzed human umbilical-cord-derived MSCs from 32 donors and revealed donor-dependent variations in two non-correlated properties; cell proliferation, and immune modulatory functions in vitro and in vivo, which might explain inconsistent clinical efficacies of MSCs.
    [Cell Death & Disease]

    Full Article

    Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19

    Scientists evaluated the safety and describe the clinical changes after IV administration of allogeneic human umbilical cord MSCs, in patients with bilateral pneumonia caused by COVID-19, complicated with severe acute respiratory distress syndrome, as compassionate treatment.
    [Aging and Disease]

    Abstract

    Transplantation of Human Amniotic Epithelial Cells Promotes Morphological and Functional Regeneration in a Rat Uterine Scar Model

    Researchers investigated whether human amniotic epithelial cells transplantation has the therapeutic effects on the rat uterine scar following full-thickness injury.
    [Stem Cell Research & Therapy]

    Full Article

    Intrabone Infusion for Allogeneic Umbilical Cord Blood Transplantation in Children

    Investigators conducted a Phase I-II single arm, exploratory clinical trial from 2012 to 2016 in a single center. 15 patients aged from 1.9 to 16.4 years received an intrabone umbilical cord blood transplantation.
    [Bone Marrow Transplantation]

    Abstract

    Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

    The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.
    [International Journal of Molecular Sciences]

    Full Article

    Assessment of the Neuroprotective and Stemness Properties of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells under Variable (5% vs. 21%) Aerobic Conditions

    Scientists investigated ten different properties of these cells cultured under 21% and 5% oxygen concentrations.
    [Cells]

    Full ArticleGraphical Abstract

    Effect of Long-Term 3D Spheroid Culture on WJ-MSC

    Investigators developed a protocol enabling a derivation of MSC subpopulation with increased expression of pluripotent and neural genes.
    [Cells]

    Full ArticleGraphical Abstract

    Explore scientific events this April with the Science Events Calendar.
    REVIEWS

    The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

    The authors discuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
    [International Journal of Molecular Sciences]

    Full Article
    INDUSTRY AND POLICY NEWS

    Athersys Reports That Healios Has Completed Enrollment in the ONE-BRIDGE Study of MultiStem® for Acute Respiratory Distress Syndrome in Japan

    Athersys, Inc. announced that its partner HEALIOS K.K. has completed enrollment in the ONE-BRIDGE study in Japan evaluating MultiStem® in patients with acute respiratory distress syndrome (ARDS) caused by pneumonia.
    [Athersys, Inc]

    Press Release
    FEATURED EVENT

    Epigenetic Therapeutic Target Summit

    Jul 13 – 15, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – MSCs in Female Infertility Disorders

    University of Chicago – Chicago, Illinois, United States

    Journal Editor – Blood Cancer Discovery and Cancer Immunology

    American Association for Cancer Research – Boston, Massachusetts, United States

    Postdoctoral Fellow – Myeloma Tumor Microenvironment

    Moores Cancer Center – La Jolla, California, United States

    Assistant Professor – Hematology

    University of Washington – Seattle, Washington, United States

    Lab Scientist – Tissue and Cellular Therapy

    The University of Iowa – Iowa City, Iowa, United States

    > See All Jobs

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