Cord Blood News Volume 13.13 | Apr 15 2021

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    2021-04-15 | CBN 13.13


    Cord Blood News by STEMCELL Technologies
    Vol. 13.13 – 15 April, 2021
    TOP STORY

    Extracellular Vesicles Derived from Umbilical Cord Mesenchymal Stromal Cells Alleviate Pulmonary Fibrosis by Means of Transforming Growth Factor-β Signaling Inhibition

    The therapeutic effects of umbilical cord MSC-derived extracellular vesicleson pulmonay fibrosis were evaluated using bleomycin-induced mouse models.
    [Stem Cell Research & Therapy]

    Full Article
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    An Induced Pluripotent Stem Cell Line (GZHMCi004-A)) Derived from a Fetus with Heterozygous G380R Mutation in FGFR3 Gene Causing Achondroplasia

    Scientists generated an induced pluripotent stem cell line GZHMCi004-A derived from umbilical cord blood mononuclear cells of a fetus with heterozygous G380R mutation in FGFR3 gene.
    [Stem Cell Research]

    Abstract

    Extracellular Vesicle-Derived microRNA-18b Ameliorates Preeclampsia by Enhancing Trophoblast Proliferation and Migration via Notch2/TIM3/mTORC1 Axis

    Researchers studied the underlying mechanism of extracellular vesicle‐derived microRNA‐18 in preeclampsia.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Dodging COVID-19 Infection: Low Expression and Localization of ACE2 and TMPRSS2 in Multiple Donor-Derived Lines of Human Umbilical Cord-Derived Mesenchymal Stem Cells

    Expression of Angiotensin-Converting Enzyme 2 (ACE2) and transmembrane Serine Protease 2 (TMPRSS2) was analyzed in 24 lots of human umbilical cord-MSCs derived from Wharton’s jelly via quantitative PCR, Western Blot, immunofluorescence and flow cytometry using 24 different donors.
    [Journal of Translational Medicine]

    Full Article

    Imbalance between Inflammatory and Regulatory Cord Blood B Cells Following Pre-Term Birth

    Researchers concluded that, after pre-term birth onset, a shift from immunoregulation towards inflammation takes place in cord blood cells that were reportedly representative of the fetal compartment.
    [Journal of Reproductive Immunology]

    Abstract

    Insights into Intrauterine Growth Restriction Based on Maternal and Umbilical Cord Blood Metabolomics

    Untargeted nuclear magnetic resonance metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 intrauterine growth restriction and 36 appropriate for gestational age deliveries.
    [Scientific Reports]

    Full Article

    In Utero Exposure to Chlordecone Affects Histone Modifications and Activates LINE-1 in Cord Blood

    Investigators examined the epigenetic effects induced by in utero chlordecone exposure on human male cord blood as well as in blood-derived Ke-37 cell line.
    [Life Science Alliance]

    Full Article
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    REVIEWS

    Mesenchymal Stem/Stromal Cell-Based Therapy: Mechanism, Systemic Safety and Biodistribution for Precision Clinical Applications

    Scientists summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs.
    [Journal of Biomedical Science]

    Full Article
    INDUSTRY AND POLICY NEWS

    Sentien Biotechnologies Completes Enrollment of First Cohort in Phase I/II Trial of Ex Vivo MSC Therapy for the Treatment of Severe COVID-19

    Sentien Biotechnologies, Inc. announced it has completed enrollment of the first cohort in its Phase I/II study of SBI-101 for the treatment of severe COVID-19. SBI-101 is being evaluated in COVID-19 patients suffering from both acute respiratory distress syndrome and acute kidney injur requiring renal replacement therapy.
    [Sentien Biotechnologies, Inc.]

    Press Release

    Celularity Receives Orphan Drug Designation for Natural Killer Cell Therapy CYNK-001 in the Treatment of Malignant Gliomas

    Celularity, Inc. announced FDA has granted Orphan Drug Designation to the company’s non-genetically modified cryopreserved human placental hematopoietic stem cell-derived natural killer cell therapy, CYNK-001, for the treatment of patients with malignant gliomas.
    [Celularity, Inc.]

    Press Release

    Therapeutic Solutions International with Subsidiary Campbell Neurosciences Develops Cord Blood Based Inhalable Product for Opioid Addiction

    Therapeutic Solutions International, Inc., announced filing of a patent with new data covering a cord blood based intranasal product demonstrated to reduce adverse mental effects associated with opioid addiction.
    [Therapeutic Solutions International, Inc. (PR Newswire)]

    Press Release
    FEATURED EVENT

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    September 22 – 24, 2021
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    JOB OPPORTUNITIES

    Postdoctoral Fellow or Research Scientist – Cell and Gene Therapy of Cancer

    Rutgers University – New Brunswick, New Jersey, United States

    Postdoctoral Fellow – MSCs in Female Infertility Disorders

    University of Chicago – Chicago, Illinois, United States

    Journal Editor – Blood Cancer Discovery and Cancer Immunology

    American Association for Cancer Research – Boston, Massachusetts, United States

    Postdoctoral Fellow – Myeloma Tumor Microenvironment

    Moores Cancer Center – La Jolla, California, United States

    Assistant Professor – Hematology

    University of Washington – Seattle, Washington, United States

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