 | | Vol. 13.15 – 29 April, 2021 |
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| To investigate the functions of exosomes derived from human umbilical cord MSC (hucMSC-ex) in a rat model of acute skin photodamage, immunofluorescence and immunohistochemical staining, quantitative real-time-polymerase chain reaction, western blot, and gene silencing assays were performed.
[Aging] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established the original footprint-free Vietnamese human induced pluripotent stem cell line, VRISGi001-A, from cord-blood derived CD34+ hematopoietic stem cells of a 35 year old healthy woman under cGMP-compliant process.
[Stem Cell Research] |
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| Motor function was analyzed by three behavioral tests. Engraftment of human amniotic fluid stem cell in organs were assessed by flow cytometry and RNA scope.
[Scientific Reports] |
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| Investigators hypothesized that the perivascular properties of human umbilical cord perivascular cells could reduce vascular dysfunction after modelled traumatic brain injury by preserving the pericyte-endothelial interactions.
[Journal of Neurotrauma] |
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| Scientists investigated whether icrovesicles derived from human Wharton’s jelly MSCs regulated macrophage polarization and ameliorated renal fibrosis following ischemia-partial nephrectomy via transferring hepatocyte growth factor.
[Human Cell] |
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| Researchers compared the angiogenic potential of MSCs obtained from bone marrow, adipose tissue and umbilical cord matrix that were genetically modified with VEGF‐encoding minicircle vectors.
[Journal of Gene Medicine] |
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| The authors induced human umbilical cord (hUC)-MSCs to differentiate into type 2 alveolar epithelial cells (AEC2s), and provided evidence that intratracheal transplantation of hUC-MSC-derived AEC2s could improve mortality and alleviate fibrosis in bleomycin-induced pulmonary fibrosis mice.
[Stem Cells and Development] |
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| Scientists focus on expression of chemokine receptors and chemokine ligands by MSCs isolated from different tissues.
[Journal of Translational Medicine] |
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| Sorrento Therapeutics, Inc. announced the completion of enrollment in its Phase Ib study of human allogeneic adipose-derived MSCs infusions to treat COVID-19 induced acute respiratory failure or acute respiratory distress syndrome.
[Sorrento Therapeutics, Inc.] |
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| Hope Biosciences Stem Cell Research Foundation received FDA authorization for a Phase II clinical trial to assess the efficacy and safety of multiple intravenous infusions of autologous adipose-derived MSCs in improving activities of daily living and quality of life in subjects with Parkinson’s Disease.
[Hope Biosciences Stem Cell Research Foundation] |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Zhejiang University – Zhejiang, China |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | Moores Cancer Center – La Jolla, California, United States |
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