Cord Blood News Volume 13.17 | May 13 2021

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    Justin.choi
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    CBN 13.17 | May 13 2021


    Cord Blood News by STEMCELL Technologies
    Vol. 13.17 – 13 May, 2021
    TOP STORY

    Hematopoietic Stem Cells Retain Functional Potential and Molecular Identity in Hibernation Cultures

    The authors describe a powerful seven day hematopoietic stem cell (HSC) hibernation culture system that maintained HSCs as single cells in the absence of a physical niche.
    [Stem Cell Reports]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    PINK1 Contained in huMSC-Derived Exosomes Prevents Cardiomyocyte Mitochondrial Calcium Overload in Sepsis via Recovery of Mitochondrial Ca2+ Efflux

    Investigators elucidated the mechanism of sepsis-induced myocardial injury and examined the value of human umbilical cord MSCs (huMSCs) for protecting cardiac function in sepsis.
    [Stem Cell Research & Therapy]

    Full Article

    Umbilical Mesenchymal Stem Cell-Derived Extracellular Vesicles as Enzyme Delivery Vehicle to Treat Morquio a Fibroblasts

    Researchers cultured human umbilical MSCs (UMSCs), demonstrated presence of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme activity within the extracellular vesicles (EVs) derived from these UMSC, and studied how these secreted EVs were taken up by GALNS-deficient cells and used by the deficient cell’s lysosomes.
    [Stem Cell Research & Therapy]

    Full Article

    Bioprinting of Human Cord Blood-Derived CD34+ Cells and Exploration of the Multilineage Differentiation Ability In Vitro

    Scientists fabricated coaxial extruded core–shell tubular scaffolds and extrusion-based bioprinted cell-laden mesh scaffolds to mimic the functional niche in vitro.
    [ACS Biomaterials Science & Engineering]

    Abstract

    Identification and Characterization of Maternal Perivascular SUSD2+ Placental Mesenchymal Stem/Stromal Cells

    Perivascular placental MSCs were isolated from the maternal placenta using SUSD2 magnetic bead sorting and assessed for the colony-forming unit-fibroblasts, surface markers, and in vitro differentiation into mesodermal lineages.
    [Cell and Tissue Research]

    Abstract

    Type 2 and Type 3 Innate Lymphoid Cells at the Maternal-Fetal Interface: Implications in Preterm Birth

    Researchers analyzed the relative frequencies of innate lymphoid cells subsets in pregnancy and the levels of IL-4, IL-17, IL-22, and IFN-γ as inflammatory mediators.
    [BMC Immunology]

    Full Article


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    REVIEWS

    Mesenchymal Stem Cells for Cardiac Regeneration: from Differentiation to Cell Delivery

    Scientists focus on the strategies used to derive cardiomyocytes-like cells from MSCs isolated from three widely used tissue sources and their differentiation efficiencies.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Therapeutic Solutions International Subsidiary Campbell Neurosciences Reports Positive Preclinical Data in Animal Model of Schizophrenia Using Proprietary Universal Donor Mesenchymal Stem Cell

    Therapeutic Solutions International, Inc. and its subsidiary Campbell Neurosciences announced new data covered by its previously filed patents supporting the use of mesenchymal based stem cell therapy for schizophrenia.
    [Therapeutic Solutions International, Inc. (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

    Myeloid Cells: From Development to Function and Dysfunction

    June 4, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Cell Therapy

    Astellas Pharma – Westborough, Massachusetts, United States

    Senior Scientific Editor – Cell Stem Cell

    Elsevier – Cambridge, Massachusetts, United States

    Chair – Gastrointestinal and Pancreatic Cancer Research

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Postdoctoral Researcher Fellowships – Center for Stem Cell and Regenerative Medicine

    Zhejiang University – Zhejiang, China

    Senior Research Assistant – Leukemia

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

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