Cord Blood News Volume 13.18 | May 20 2021

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    CBN 13.18 | May 20 2021


    Cord Blood News by STEMCELL Technologies
    Vol. 13.18 – 20 May, 2021
    TOP STORY

    Cytokine Combinations for Human Blood Stem Cell Expansion Induce Cell Type- and Cytokine-Specific Signaling Dynamics

    By combining fluorescent biosensors with time-lapse imaging and microfluidics, researchers measured the activity of the extracellular signal-regulated kinase pathway over time in live single human umbilical cord blood hematopoietic stem cells and multipotent progenitor cells.
    [Blood]

    Abstract

    Learn more about cGMP-manufactured StemSpanâ„¢-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    PUBLICATIONSRanked by the impact factor of the journal

    Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Cord Blood-Derived NK Cells Facilitates CAR-Like Responses against CD30+ Malignancies

    The combination of AFM13 and IL-12/15/18 pre-activation of blood and cord-blood-derived natural killer cells was investigated in vitro and in vivo.
    [Clinical Cancer Research]

    Abstract

    Enhanced Differentiation of Functional Human T Cells in NSGW41 Mice with Tissue-Specific Expression of Human Interleukin-7

    After transfer of human cord blood-derived hematopoietic stem and progenitor cells, transgenic mice on the NSGW41 background, termed NSGW41hIL7, showed elevated and prolonged human cellularity in the thymus.
    [Leukemia]

    Full Article

    Umbilical Cord Blood Transplants Facilitated by the French Cord Blood Banks Network. On Behalf of the Agency of Biomedicine, Eurocord and the French Society of Bone Marrow Transplant and Cell Therapy (SFGM-TC)

    Researchers described the results of umbilical cord blood transplants (UCBT) facilitated by a national network that used the same criteria of UCB collection and banking and to assess how modifications of banking criteria and unit selection might influence transplant outcomes.
    [Bone Marrow Transplantation]

    Full Article

    Evaluation of a Clinical-Grade, Cryopreserved, Ex Vivo-Expanded Stem Cell Product from Cryopreserved Primary Umbilical Cord Blood Demonstrates Multilineage Hematopoietic Engraftment in Mouse Xenografts

    Current Good Manufacturing Practice valproic acid-mediated expansion was initiated with CD34+ cells isolated from cryopreserved primary umbilical cord blood collections, and the functionality after a second cryopreservation step of the expanded product evaluted in vitro and in mouse xenografts.
    [Cytotherapy]

    Full Article

    Human Delta Like 1-Expressing Human Mesenchymal Stromal Cells Promote Human T Cell Development and Antigen-Specific Response in Humanized NOD/SCID/IL-2Rγnull (NSG) Mice

    Co-injection of human delta-like 1-human mesenchymal stromal cells with hCD34+ cord blood cells into the liver of NSG mice markedly suppressed the development of human T cells.
    [Scientific Reports]

    Full Article

    Survey results on the needs and challenges in the human pluripotent stem cell field
    REVIEWS

    The Effects of Locomotion on Bone Marrow Mesenchymal Stem Cell Fate: Insight Into Mechanical Regulation and Bone Formation

    Scientists summarize the regulatory effects of locomotion/mechanical loading on bone marrow mesenchymal stem cell activities.
    [Cell and Bioscience]

    Full Article

    INDUSTRY AND POLICY NEWS

    Sandoz Canada Launches Its 6th Biosimilar with PrInclunox® and PrInclunox® HP

    Sandoz Canada, Inc. announced today the launch of PrInclunox® and PrInclunox® HP. It is one of the first companies to make available a biosimilar version of enoxaparin sodium solution for injection, thus contributing to potentially help lower healthcare costs for Canadian hospitals and private and public payers.
    [Sandoz Canada, Inc.]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Primary Human Tumors

    Louisiana State University – New Orleans, Louisiana, United States

    Research Associate – Cell Therapy

    Astellas Pharma – Westborough, Massachusetts, United States

    Research Associate – Cancer Stem Cell Biology

    City of Hope – Duarte, California, United States

    Chair – Gastrointestinal and Pancreatic Cancer Research

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Postdoctoral Researcher Fellowships – Center for Stem Cell and Regenerative Medicine

    Zhejiang University – Zhejiang, China

    > See All Jobs

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