| Vol. 13.19 – 27 May, 2021 |
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| A first genetic hit led to the expansion of pre-leukemic B-cell clones, which were detectable in healthy newborn cord blood. These pre-leukemic clones gave rise to clinically overt leukemia in only about 0.2% of carriers. [Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Logistic and negative binomial regression were used to assess the impact of maternal peripheral parasitemia, symptomatic malaria, and placental malaria on cord blood maternal microchimerism. [The Journal of Infectious Diseases] |
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| Researchers compared the effectiveness of conditioned medium of MSCs derived from induced pluripotent stem cells with that derived from umbilical cord MSCs in a mouse cutaneous wound healing model. [Stem Cell Research & Therapy] |
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| Scientists reported human inducible regulatory T cells (iTreg) co-cultured with bone marrow-derived MSCs during short-term ex vivo expansion enhances the stability of iTreg FOXP3 expression and suppressive function in vitro and in vivo, and further that a key mechanism of action is MSC mitochondrial transfer via tunneling nanotubules. [Scientific Reports] |
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| Investigators conducted a multicenter Phase IIa study to explore whether eltrombopag, a thrombopoietin-receptor agonist, would enhance platelet recovery after umbilical cord blood transplantation. [Leukemia & Lymphoma] |
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| Retrospective data analysis compared laboratory and clinical outcomes following single-unit umbilical cord blood transplantation performed between 1999 and 2015. [Transfusion] |
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| Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived MSCs migration involving matrix metalloproteinase-3. [PLOS ONE] |
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| The authors review the biological mechanisms of endometrial regeneration, and research progress and challenges for adult stem cell therapy for damaged endometrium. [Molecular Reproduction & Development] |
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| Sorrento Therapeutics, Inc. announced receipt of clearance from the ANVISA to proceed with a Phase II Pivotal clinical trial of COVI-MSCâ„¢, an injectable infusion of MSCs, for the treatment of hospitalized COVID-19 patients suffering from acute respiratory distress syndrome. [Sorrento Therapeutics, Inc.] |
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| June 28 – 29, 2021 Virtual |
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| University of British Columbia – Vancouver, British Columbia, Canada |
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| Columbia University Medical Center – New York, New York, United States |
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| Astellas Pharma – Westborough, Massachusetts, United States |
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| City of Hope – Duarte, California, United States |
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| Zhejiang University – Zhejiang, China |
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