Cord Blood News Volume 13.19 | May 27 2021

    0
    93






    2021-05-27 | CBN 13.19


    Cord Blood News by STEMCELL Technologies
    Vol. 13.19 – 27 May, 2021
    TOP STORY

    Towards Prevention of Childhood ALL by Early-Life Immune Training

    A first genetic hit led to the expansion of pre-leukemic B-cell clones, which were detectable in healthy newborn cord blood. These pre-leukemic clones gave rise to clinically overt leukemia in only about 0.2% of carriers.
    [Blood]

    Abstract


    Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Peripheral Plasmodium falciparum Infection in Early Pregnancy Is Associated with Increased Maternal Microchimerism in the Offspring

    Logistic and negative binomial regression were used to assess the impact of maternal peripheral parasitemia, symptomatic malaria, and placental malaria on cord blood maternal microchimerism.
    [The Journal of Infectious Diseases]

    Abstract

    Conditioned Medium from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Accelerates Cutaneous Wound Healing through Enhanced Angiogenesis

    Researchers compared the effectiveness of conditioned medium of MSCs derived from induced pluripotent stem cells with that derived from umbilical cord MSCs in a mouse cutaneous wound healing model.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stromal Cell Mitochondrial Transfer to Human Induced T-Regulatory Cells Mediates FOXP3 Stability

    Scientists reported human inducible regulatory T cells (iTreg) co-cultured with bone marrow-derived MSCs during short-term ex vivo expansion enhances the stability of iTreg FOXP3 expression and suppressive function in vitro and in vivo, and further that a key mechanism of action is MSC mitochondrial transfer via tunneling nanotubules.
    [Scientific Reports]

    Full Article

    Eltrombopag for Enhancement of Platelet Engraftment in Patients Undergoing Allogeneic Cord Blood Transplantation

    Investigators conducted a multicenter Phase IIa study to explore whether eltrombopag, a thrombopoietin-receptor agonist, would enhance platelet recovery after umbilical cord blood transplantation.
    [Leukemia & Lymphoma]

    Abstract

    Analysis of Outcomes of Single-Unit Cord Blood Transplantation with Umbilical Cord Blood Units Processed with Two Different Red Blood Cell Sedimentation Reagents

    Retrospective data analysis compared laboratory and clinical outcomes following single-unit umbilical cord blood transplantation performed between 1999 and 2015.
    [Transfusion]

    Abstract

    Interleukin-1β-Induced Matrix Metalloproteinase-3 via ERK1/2 Pathway to Promote Mesenchymal Stem Cell Migration

    Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived MSCs migration involving matrix metalloproteinase-3.
    [PLOS ONE]

    Full Article

    Explore scientific events this June with the Science Events Calendar.
    REVIEWS

    Adult Stem Cells in Endometrial Regeneration: Molecular Insights and Clinical Applications

    The authors review the biological mechanisms of endometrial regeneration, and research progress and challenges for adult stem cell therapy for damaged endometrium.
    [Molecular Reproduction & Development]

    Full Article

    INDUSTRY AND POLICY NEWS

    Brazilian Health Regulatory Agency (ANVISA) Authorizes Sorrento Phase II Pivotal Clinical Trial of COVI-MSCâ„¢ in Hospitalized COVID-19 Patients with Acute Respiratory Distress Syndrome

    Sorrento Therapeutics, Inc. announced receipt of clearance from the ANVISA to proceed with a Phase II Pivotal clinical trial of COVI-MSCâ„¢, an injectable infusion of MSCs, for the treatment of hospitalized COVID-19 patients suffering from acute respiratory distress syndrome.
    [Sorrento Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Sarcomas

    June 28 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Stem Cell Derived Therapeutics

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – Stemness Control in Pluripotent and Cancer Cells

    Columbia University Medical Center – New York, New York, United States

    Research Associate – Cell Therapy

    Astellas Pharma – Westborough, Massachusetts, United States

    Research Associate – Cancer Stem Cell Biology

    City of Hope – Duarte, California, United States

    Postdoctoral Researcher Fellowships – Center for Stem Cell and Regenerative Medicine

    Zhejiang University – Zhejiang, China

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cord Blood News Twitter