Cord Blood News Volume 13.20 | June 3 2021

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    2021-06-03 | CBN 13.20


    Cord Blood News by STEMCELL Technologies
    Vol. 13.20 – 3 June, 2021
    TOP STORY

    Melatonin Augments the Neuroprotective Effects of Hypothermia in Lambs following Perinatal Asphyxia

    Scientists induced asphyxia in fetal sheep via umbilical cord occlusion until mean arterial blood pressure fell from 55 ± 3 mmHg in sham controls to 18-20 mmHg.
    [Journal of Pineal Research]

    Abstract

    Find the Right Antibodies for Your Stem Cell Research. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in a Nutritionally Deficient Environment

    PMNT was confirmed to promote human umbilical cord-derived MSC proliferation in a serum-free medium by driving cell cycles and up-regulating gene expression in the pathways of biosynthesis and the metabolism.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    Non-Transplantable Cord Blood Units as a Source for Adoptive Immunotherapy of Leukemia and a Paradigm of Circular Economy in Medicine

    Scientists explored the feasibility of generating bivalent-Leuk-STs directed against Wilms tumor 1 and preferentially expressed antigen in melanoma from umbilical cord blood units disqualified for allogeneic hematopoietic stem cell transplantation.
    [British Journal of Haematology]

    Abstract

    hAECs and Their Exosomes Improve Cardiac Function after Acute Myocardial Infarction in Rats

    Researchers cultured human amniotic epithelial cells (hAECs) and extracted exosomes from culture supernatants. They established a stable acute myocardial infarction model in rats and treated them with hAECs, exosomes, or PBS.
    [Aging]

    Full Article

    Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Experimental Autoimmune Encephalomyelitis via Regulating Pro and Anti-Inflammatory Cytokines

    Scientists investigated the effect of extracellular vesicles derived from human umbilical cord-MSC on the clinical score and inflammatory/anti-inflammatory cytokines on the experimental autoimmune encephalomyelitis mouse model.
    [Scientific Reports]

    Full Article

    Matrigel/Umbilical Cord-Derived Mesenchymal Stem Cells Promote Granulosa Cell Proliferation and Ovarian Vascularization in a Mouse Model of Premature Ovarian Failure

    Investigators aimed to fabricate a Matrigel scaffold loaded with human umbilical cord-derived MSCs and explore its potential to restore ovarian function and repair ovarian structures in vitro and in vivo.
    [Stem Cells and Development]

    Abstract

    Allogeneic Human Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells for Chronic Obstructive Pulmonary Disease (COPD): Study Protocol for a Matched Case-Control, Phase I/II Trial

    Researchers investigated the safety and potential therapeutic efficacy of allogeneic administration of umbilical cord-derived MSCs as a supplementary intervention in combination with standard COPD medication treatments in patients with moderate-to-severe COPD.
    [BMJ Open]

    Abstract

    Human-Derived Treg and MSC Combination Therapy May Augment Immunosuppressive Potency In Vitro, but Did Not Improve Blood Brain Barrier Integrity in an Experimental Rat Traumatic Brain Injury Model

    The authors compared the ability of regulatory T cells (Treg) + mesenchymal stromal cells (MSC) combination therapy, as well as MSC and Treg monotherapies, to improve blood brain barrier permeability in vivo and suppress inflammation in vitro.
    [PLOS One]

    Full Article

    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Mesenchymal Stem Cells and Extracellular Vesicles for the Treatment of Pain: Current Status and Perspectives

    Investigators provide a detailed description of the functional properties of MSCs and extracellular vesicles and their potential clinical applications, with a special focus on pain treatment.
    [British Journal of Pharmacology]

    Abstract

    Allogeneic Hematopoietic Cell Transplantation for Myelofibrosis: Proposed Definitions and Management Strategies for Graft Failure, Poor Graft Function and Relapse: Best Practice Recommendations of the EBMT Chronic Malignancies Working Party

    A systematic approach to molecular monitoring, histopathological assessment and chimerism testing is proposed. These proposed recommendations aim to increase the accuracy and uniformity of reporting and to thereby facilitate the development of more consistent approaches.
    [Leukemia]

    Abstract

    INDUSTRY AND POLICY NEWS

    Limit on Lab-Grown Human Embryos Dropped by Stem-Cell Body

    The International Society for Stem Cell Research relaxed the famous 14-day rule on culturing human embryos in its latest research guidelines.
    [Nature News]

    Press Release

    FEATURED EVENT

    AACR Virtual Meeting: Clonal Hematopoiesis

    August 18 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Hematopoiesis and Leukemia

    UT Southwestern Medical Center – Dallas, Texas, United Statess

    Laboratory Technologist – Histocompatibility

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Postdoctoral Fellow – Stem Cell Derived Therapeutics

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – Stemness Control in Pluripotent and Cancer Cells

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral Researcher Fellowships – Center for Stem Cell and Regenerative Medicine

    Zhejiang University – Zhejiang, China

    > See All Jobs

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