 | | Vol. 13.23 – 24 June, 2021 |
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| Investigators reported results of a Phase III trial to evaluate the efficacy of omidubicel compared to standard umbilical cord blood transplantation.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that hiPSC-extracellular vesicles improved functional properties of cord blood-HSPCs critical for their hematopoietic capacity including metabolic, hematopoietic and clonogenic potential as well as survival, chemotactic response to stromal cell-derived factor 1 and adhesion to the model components of hematopoietic niche in vitro.
[Leukemia] |
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| Scientists assessed the association between medically assisted reproduction and DNA methylation at birth in cord blood at over 450 000 CpG sites across the genome in two sub-samples of the UK Avon Longitudinal Study of Parents and Children and two sub-samples of the Norwegian Mother, Father and Child Cohort Study by meta-analysis.
[Human Reproduction] |
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| The authors investigated the associations between gestational mercury exposure and frequency of cord blood T cells as well as placental gene expression.
[Environmental Research] |
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| Scientists examined the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with type 1 diabetes.
[Stem Cell Research & Therapy] |
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| The survival and colonization of exogenous placental chorionic plate-derived MSCs were observed by bioluminescence imaging and CM-Dil labeling in rodent animal models of severe acute pancreatitis.
[Stem Cell Research & Therapy] |
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| The authors generated a rat xenotransplantation model to prove the role of macrophages as a xenotransplantation barrier. Immunodeficiency in SRG rats, which were Sprague–Dawley rats lacking Rag2 and Il2rg, was confirmed by flow cytometry and spleen immunostaining.
[Xenotransplantation] |
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| Scientists developed and validated nomograms and a web application to predict the overall survival of patients with non-complete remission acute myeloid leukemia undergoing allo-HCT cord blood transplantation, bone marrow transplantation, and peripheral blood stem cell transplantation.
[Cancer Medicine] |
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| The combined effects of HLA-allele matching at six-loci and CD34+ cell dose on clinical outcomes were analyzed in 1,226 adult cases with single-unit unrelated cord blood transplantation.
[Leukemia & Lymphoma] |
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| Scientists evaluated the in vitro anti-viral activities of combinations of certain commercially available drugs that have recently formed part of COVID-19 therapy. These drugs were mixed at specific ratios and evaluated for their safe use based on the cytotoxicity concentration values of human umbilical cord mesenchymal stem cells.
[PLOS One] |
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| Research attributes both pro-tumor and anti-tumor actions to MSCs; however, evidence indicates that MSCs specific effect on the tumor depends on the source of the MSCs and the type of tumor.
[Cell & Bioscience] |
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| The authors discuss the mechanistic effects of MSCs with a focus on human amniotic epithelial cells, which can be used to treatment and improvement of outcome in multiple sclerosis disease.
[World Journal of Stem Cells] |
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| A partnership between The University of Texas at El Paso (UTEP) and Texas Tech Health Sciences Center El Paso (TTUHSC El Paso) designed to expand health research in the Paso del Norte region has identified studies which could have significant impact on the well-being of the community.
[The El Paso Herald-Post] |
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| Hope Biosciences Stem Cell Research Foundation received FDA authorization for a Phase II clinical trial to assess the efficacy and safety of multiple intravenous infusions of autologous adipose-derived MSCs in improving activities of daily living and quality of life in subjects with Parkinson’s Disease.
[Hope Biosciences Stem Cell Research Foundation] |
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| August 12 – 14, 2021
Busan, South Korea |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | FibroBiologics – Houston, Texas, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | UT Southwestern Medical Center – Dallas, Texas, United Statess |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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