Cord Blood News Volume 13.26 | Jul 22 2021

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    2021-07-22 | CBN 13.26


    Cord Blood News by STEMCELL Technologies
    Vol. 13.26 – 22 July, 2021
    TOP STORY

    Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Pulmonary Fibrosis via Regulatory T Cell through Interaction with Macrophage

    The molecular and cellular behavior of human umbilical cord MSC was investigated in a bleomycin-induced mouse pulmonary fibrosis model.
    [Stem Cell Research & Therapy]

    Full Article

    Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    PUBLICATIONSRanked by the impact factor of the journal

    Cell Therapy in Patients with COVID-19 Using Wharton’s Jelly Mesenchymal Stem Cells: A Phase I Clinical Trial

    Researchers assessed the safety and efficacy of injecting intravenous Wharton’s jelly-derived MSCs in patients with COVID-19 as a treatment. Five patients with severe COVID-19 were treated with Wharton’s jelly-derived MSCs.
    [Stem Cell Research & Therapy]

    Full Article

    Cell Heterogeneity, Rather than the Cell Storage Solution, Affects the Behavior of Mesenchymal Stem Cells In Vitro and In Vivo

    Scientists investigated the effects of storage solutions and heterogeneity on the behavior of MSCs in vitro and in vivo.
    [Stem Cell Research & Therapy]

    Full Article

    The Human Amniotic Fluid Stem Cell Secretome Triggers Intracellular Ca2+ Oscillations, NF-κB Nuclear Translocation and Tube Formation in Human Endothelial Colony-Forming Cells

    Investigators found that the secretome obtained by human amniotic fluid-derived stem cells undergoing hypoxic preconditioning induced intracellular Ca2+ oscillations by promoting extracellular Ca2+ entry through Transient Receptor Potential Vanilloid 4.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Engineered Mucoperiosteal Scaffold for Cleft Palate Regeneration towards the Non-immunogenic Transplantation

    The authors set up a new natural scaffold deriving from a decellularized porcine mucoperiosteum, engineered by an innovative micro-perforation procedure based on Quantum Molecular Resonance and then subjected to in vitro recellularization with human bone marrow-derived MSCs.
    [Scientific Reports]

    Full Article

    A Comparative Study of Mesenchymal Stem Cell Transplantation and NTG-101 Molecular Therapy to Treat Degenerative Disc Disease

    Investigators compared the therapeutic potential of a novel drug candidate, NTG-101 to MSCs, including rat cartilage derived stem cells, bone marrow stem cells and human umbilical cord derived MSCs for the treatment of Degenerative Disc Disease.
    [Scientific Reports]

    Full Article

    Comparing Effects and Action Mechanisms of BPA and BPS on HTR-8/SVneo Placental Cells

    Researchers elucidated and compared the effects of bisphenol A (BPA) and BPS on physiological functions of HTR-8/SVneo cells, derived from extravillous trophoblast of first-trimester pregnancy.
    [Biology of Reproduction]

    Abstract

    Exosomal microRNA-1246 from Human Umbilical Cord Mesenchymal Stem Cells Potentiates Myocardial Angiogenesis in Chronic Heart Failure

    Cardiac function, myocardial infarction area, apoptosis, and angiogenesis were all evaluated in a chronic heart failure rat model following treatment with human umbilical cord MSC-derived exosomes.
    [Cell Biology International]

    Abstract

    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    REVIEWS

    Mesenchymal Stem Cells: Ideal Seeds for Treating Diseases

    MSCs, a kind of multipotent stem cells with self-renewal ability and multi-differentiation ability, have become the “practical stem cells” for the treatment of diseases.
    [Human Cell]

    Full Article

    INDUSTRY AND POLICY NEWS

    Brooklyn ImmunoTherapeutics Completes Acquisition of Novellus Therapeutics

    Brooklyn ImmunoTherapeutics, Inc. has announced that it had completed its acquisition of Novellus Therapeutics Limited. Novellus is developing next‑generation engineered MSC therapies using extensively patented mRNA-based cell reprogramming and gene editing technologies.
    [Brooklyn ImmunoTherapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Cord Blood Connect 2021

    September 23 – 30, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Position – Leukemia

    Princess Margaret Cancer Centre – Toronto, Ontario, United States

    Scientist – Pathology and Laboratory Medicine

    Medical University of South Carolina – Charleston, South Carolina, United States

    Research Assistant – Immunobiology of MSCs

    Mercer University – Savannah, Georgia, United States

    Assistant, Associate, or Full Professor – Stem Cell Biology and Regenerative/Restorative Medicine

    Stanford University – Palo Alto, California, United States

    Chief Scientific Officer – Fibroblasts and Stem Cells

    FibroBiologics – Houston, Texas, United States

    > See All Jobs

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