Cord Blood News Volume 13.28 | Aug 5 2021

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    2021-08-05 | CBN 13.28


    Cord Blood News by STEMCELL Technologies
    Vol. 13.28 – 5 August, 2021
    TOP STORY

    Human Amniotic Mesenchymal Stromal Cells Support the Ex Vivo Expansion of Cord Blood Hematopoietic Stem Cells

    Scientists investigated if MSCs derived from the amniotic membrane could support the ex vivo expansion of hematopoietic stem cell and progenitor cells.
    [Stem Cells Translational Medicine]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    3D Migration of Human Amniotic Fluid Stem Cells Involves Mesenchymal and Amoeboid Modes and Is Regulated by mTORC1

    Using two different kinds of invasion assays, this study aimed at investigating and characterizing the 3D migratory capacity of human amniotic fluid stem cells, a well-established fetal stem cell type.
    [Stem Cells]

    Full Article

    Addressing the Liver Progenitor Cell Response and Hepatic Oxidative Stress in Experimental Non-Alcoholic Fatty Liver Disease/Non-Alcoholic Steatohepatitis Using Amniotic Epithelial Cells

    The authors examined the effect human amniotic epithelial cells had on the liver progenitor cell response and hepatic oxidative stress in an experimental model of non-alcoholic steatohepatitis.
    [Stem Cell Research & Therapy]

    Full Article

    Clinical Experience on Umbilical Cord Mesenchymal Stem Cell Treatment in 210 Severe and Critical COVID-19 Cases in Turkey

    Investigators evaluated the clinical outcome of severe/critically severe 210 COVID-19 patients treated with umbilical cord-MSCs.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    hucMSC-Derived Exosomes Attenuate Colitis by Regulating Macrophage Pyroptosis via the miR-378a-5p/NLRP3 Axis

    Human umbilical cord MSC-derived exosomes carrying miR-378a-5p inhibited NLRP3 inflammasomes and abrogated cell pyroptosis to protect against dextran sulfate sodium-induced colitis.
    [Stem Cell Research & Therapy]

    Full Article

    Episomal Vector Reprogramming of Human Umbilical Cord Blood Natural Killer Cells to an Induced Pluripotent Stem Cell Line MUSIi013-A

    Natural killer cells were isolated from human umbilical cord blood from a healthy newborn and reprogrammed by episomal vectors carrying reprograming factors L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1, and shRNA against p53 delivered using nucleofection.
    [Stem Cell Research]

    Abstract

    Strongyloides stercoralis and HTLV-1 Coinfection in CD34+ Cord Blood Stem Cell Humanized Mice: Alteration of Cytokine Responses and Enhancement of Larval Growth

    A model of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical cord blood hematopoietic stem cell engrafted humanized mice was established.
    [PLOS Neglected Tropical Diseases]

    Full Article

    Mesenchymal Stem Cells from Different Sources Show Distinct Therapeutic Effects in Hyperoxia-Induced Bronchopulmonary Dysplasia in Rats

    Researchers evaluated intratracheal MSCs as an approach to treat an hyperoxia-induced bronchopulmonary dysplasia animal model and compared the therapeutic effects between amniotic fluid-, umbilical cord- and bone marrow-MSCs.
    [Journal of Cellular and Molecular Medicine]

    Full Article

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    REVIEWS

    Is There a Place for Mesenchymal Stromal Cell-Based Therapies in the Therapeutic Armamentarium against COVID-19?

    The authors present a critical analysis of the risks, limitations, challenges, and opportunities that place MSC-based products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce the pandemic’s unmet medical needs.
    [Stem Cell Research & Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Gives Green Light for Multiple Sclerosis Stem Cell Trial

    Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived MSCs in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis.
    [Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Maternal-Fetal Newborn Immunity

    October 28 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Stem Cell-Based Therapy

    UCLA Jules Stein Eye Institute – Los Angeles, California, United States

    Postdoctoral Fellow – Cancer Genomics and Liquid Biopsies

    University of Gothenburg – Gothenburg, Sweden

    Postdoctoral Position – Leukemia

    Princess Margaret Cancer Centre – Toronto, Ontario, United States

    Research Assistant – Immunobiology of MSCs

    Mercer University – Savannah, Georgia, United States

    Assistant Professor – Translational Metabolism

    Dalhousie University – Halifax, Nova Scotia, Canada

    > See All Jobs

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