Cord Blood News Volume 13.31 | Aug 26 2021

May 12, 2022

109

2021-08-26 | CBN 13.31

Cord Blood News by STEMCELL Technologies

Vol. 13.31 – 26 August, 2021

TOP STORY

DL4-μbeads Induce T Cell Lineage Differentiation from Stem Cells in a Stromal Cell-Free System

The authors reported a stromal cell-free, microbead-based approach that supported the efficient in vitro development of both human progenitor T cells and T-lineage cells from CD34⁺ cells sourced from cord blood, GCSF-mobilized peripheral blood, and pluripotent stem cells.
[Nature Communications]

Full Article Press Release

Image of man completing the on-demand CFU assay course on his laptop.

PUBLICATIONSRanked by the impact factor of the journal

Elevated S100A9 in Preeclampsia Induces Soluble Endoglin and IL-1β Secretion and Hypertension via the NLRP3 Inflammasome

Scientists hypothesized that S100A9, as major alarmin, were associated with the pathogenesis of preeclampsia and induction of a preeclampsia-like phenotype in pregnant mice.
[Journal of Hypertension]

Abstract

Human Umbilical Cord Mesenchymal Stem Cells Deliver Exogenous miR-26a-5p via Exosomes to Inhibit Nucleus Pulposus Cell Pyroptosis through METTL14/NLRP3

The human umbilical cord MSC exosomes were found to effectively improve the viability of nucleus pulposus cells and protect them from pyroptosis through targeting METTL14, with a methyltransferase catalyzing m⁶A modification.
[Molecular Medicine]

Full Article

The Promise(s) of Mesenchymal Stem Cell Therapy in Averting Preclinical Diabetes: Lessons from In Vivo and In Vitro Model Systems

Investigators showed that intramuscular injection of placental (P)-MSCs homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.
[Scientific Reports]

Full Article

Cx43 Mediates Changes in Myofibroblast Contraction and Collagen Release in Human Amniotic Membrane Defects after Trauma

Scientists examined the healing mechanisms in amniotic membrane (AM) defects after trauma. Traumatised human AM defects were cultured for four days.
[Scientific Reports]

Full Article

Human Umbilical Cord-Derived Mesenchymal Stem Cell-Exosomal miR-627-5p Ameliorates Non-alcoholic Fatty Liver Disease by Repressing FTO Expression

Researchers determined whether human umbilical cord-derived-MSCs-exosomes had a hepatoprotective effect on non-alcoholic fatty liver disease.
[Human Cell]

Abstract

Successful Prediction of Human Fetal Exposure to P-gp Substrate Drugs Using the Proteomics-informed Relative Expression Factor Approach and PBPK Modeling and Simulation

Investigators used in vitro transport studies in Transwell^®, in combination with their maternal-fetal physiologically based pharmacokinetic model, to predict fetal K_p,uu of drugs that were effluxed by placental P-glycoprotein.
[Drug Metabolism and Disposition]

Abstract

Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation

REVIEWS

Infections at the Maternal–Fetal Interface: An Overview of Pathogenesis and Defence

The authors discuss how TORCH pathogens access the intra-amniotic space and overcome the placental defences that protect against microbial vertical transmission.
[Nature Reviews Microbiology]

Full Article

INDUSTRY AND POLICY NEWS

Bonus BioGroup Receives Approval to Expand Phase-II Clinical Trials for its COVID-19 Treatment to Medical Centers across Israel

Bonus BioGroup LTD, has received official approval from the Israeli Ministry of Health to expand its phase II clinical trials for its MesenCure treatment to health centers and hospitals nationwide. MesenCure leverages advances in cell therapy to treat COVID-19 patients suffering from life-threatening pneumonia, acute respiratory distress, and associated complications caused by the immune system’s hyper-inflammatory response to the virus.
[Bonus BioGroup LTD (GlobeNewswire, Inc.)]

Press Release

FEATURED EVENT

DL4-μbeads Induce T Cell Lineage Differentiation from Stem Cells in a Stromal Cell-Free System

Elevated S100A9 in Preeclampsia Induces Soluble Endoglin and IL-1β Secretion and Hypertension via the NLRP3 Inflammasome

Human Umbilical Cord Mesenchymal Stem Cells Deliver Exogenous miR-26a-5p via Exosomes to Inhibit Nucleus Pulposus Cell Pyroptosis through METTL14/NLRP3

The Promise(s) of Mesenchymal Stem Cell Therapy in Averting Preclinical Diabetes: Lessons from In Vivo and In Vitro Model Systems

Cx43 Mediates Changes in Myofibroblast Contraction and Collagen Release in Human Amniotic Membrane Defects after Trauma

Human Umbilical Cord-Derived Mesenchymal Stem Cell-Exosomal miR-627-5p Ameliorates Non-alcoholic Fatty Liver Disease by Repressing FTO Expression

Successful Prediction of Human Fetal Exposure to P-gp Substrate Drugs Using the Proteomics-informed Relative Expression Factor Approach and PBPK Modeling and Simulation

Infections at the Maternal–Fetal Interface: An Overview of Pathogenesis and Defence

Bonus BioGroup Receives Approval to Expand Phase-II Clinical Trials for its COVID-19 Treatment to Medical Centers across Israel

3D Cell Culture

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Postdoctoral Fellow – Normal and Leukemic Hematopoietic Stem Cells

Postdoctoral Associate – Stem/Progenitor Cells

Research Associate – Stem Cell Models

Postdoctoral Positions – Stem Cell-Based Therapy

Development Engineer – Cell Therapies and Regenerative Medicine

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