 | | Vol. 13.34 – 16 September, 2021 |
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| Researchers conducted a Phase I clinical trial in nine patients with mild-to-moderate Alzheimer’s disease dementia to evaluate the safety and dose-limiting toxicity of three repeated intracerebroventricular injections of human umbilical cord blood–derived MSCs.
[Alzheimer’s Research & Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists constructed CD73 modified extracellular vesicles and explored the anti-inflammatory effects after spinal cord injury. CD73 engineered extracellular vesicles were derived from human umbilical cord MSCs transduced by lentiviral vectors to upregulate the expression of CD73.
[Journal of Nanobiotechnology] |
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| A well-established concanavalin A-induced fulminant hepatitis mouse model was used to investigate the effects of transplanting human umbilical cord Wharton’s jelly-derived MSCs on fulminant hepatitis.
[Stem Cell Research & Therapy] |
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| Scientists reported that both human amniotic stem cells and their conditional medium had a potent anti-hyperpigmentation in skin in vivo and in vitro.
[Stem Cell Research & Therapy] |
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| MSCs were isolated from first-trimester and term placentae. Bone marrow-MSCs were commercially obtained. Chondrogenesis was induced by micromass culture in commercial chondrogenic media for 7, 14, or 21 days.
[Cartilage] |
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| Researchers developed a double crosslinked alginate hydrogel for 3D bioprinting, and human umbilical cord MSCs could differentiate into chondrocytes on its printed 3D scaffold after four weeks’ culture.
[Biomedical Materials] |
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| Scientists compared the effect of single and multiple injections of human umbilical cord blood-MSCs on ovarian function repair in chemotherapy-induced premature ovarian failure.
[Journal of Ovarian Research] |
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| Investigators explored the possible mechanism of HGF-transfected human umbilical cord MSCs in inhibiting the proliferation and activation of hepatic stellate cells-T6.
[Stem Cells and Development] |
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| The pathophysiology of poor graft function can be conceptualized as dysfunction related to the number or productivity of the stem cell compartment, defects in bone marrow microenvironment components such as mesenchymal stromal cells and endothelial cells, or immunological suppression of post allogeneic stem cell transplant hematopoiesis.
[Blood Advances] |
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| Dr. Lindsay Zhou recieved the 2021 European Society for Pediatric Research Young Investigator Start Up Grant of 10,000 Euros for research on treatment for preterm brain injury. The project is investigating the use of umbilical cord blood-derived stem cells as a treatment for preterm brain injury.
[Monash University] |
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| EdiGene, Inc. announced the first patient enrolled in multicenter Phase I clinical study of its investigational gene-editing hematopoietic stem cell therapy ET-01 for patients with transfusion dependent β-thalassemia at the Institute of Hematology and Blood Diseases Hospital.
[EdiGene, Inc. (Business Wire, Inc.)] |
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| September 26 – October 1, 2021
Virtual |
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| | Broad Institute – Cambridge, Massachusetts, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | Lund University – Lund, Sweden |
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| | Banner MD Anderson Cancer Center – Gilbert, Arizona, United States |
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| | Indiana University – Indianapolis, Indiana, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
