Cord Blood News Volume 13.35 | Sep 23 2021

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    2021-09-23 | CBN 13.35


    Cord Blood News by STEMCELL Technologies
    Vol. 13.35 – 23 September, 2021
    TOP STORY

    Assessment of HLA-B Genetic Variation with an HLA-B Leader Tool and Implications in Clinical Transplantation

    To optimize the selection of stem cell transplant sources based on the HLA-B leader, an HLA-B Leader Assessment Tool was developed to automate the assignment of leader genotypes, define HLA-B leader match statuses, and rank order candidate stem cell sources according to clinical risk.
    [Blood Advances]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Human Placental Mesenchymal Stem/Stromal Cells (pMSCs) Inhibit Agonist-Induced Platelet Functions Reducing Atherosclerosis and Thrombosis Phenotypes

    The authors investigated the consequences of interaction between placenta MSCs and platelets, and its impact on platelet-mediated atherosclerosis in vitro.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Mesenchymal Stem Cells Act as Stimulators of Neurogenesis and Synaptic Function in a Rat Model of Alzheimer’s Disease

    The possible roles of human umbilical mesenchymal stromal cord and adipose MSCs in neurogenesis and synaptic function were investigated using a β-amyloid 1-42-induced Alzheimer’s disease rat model.
    [Heliyon]

    Full Article

    Mesenchymal Stem Cell-Derived Exosome-Containing Linc00632 Regulates GATA Binding Protein-3 Expression in Allergic Rhinitis by Interacting with Enhancer of Zeste Homolog 2 to Inhibit T Helper Cell 2 Differentiation

    Human umbilical cord MSC-derived exosome dramatically inhibited T helper cell 2 differentiation, decreased GATA binding protein-3 protein expressions and IL-4 levels by about two times in CD4+ T cells.
    [International Archives of Allergy and Immunology]

    Abstract

    Human Umbilical Cord-Blood-Derived Mesenchymal Stem Cell Can Improve the Clinical Outcome and Joint Space Width after High Tibial Osteotomy

    Scientists compared the clinical and radiological results of human umbilical cord-blood derived MSC cartilage regeneration procedures combined with high tibial osteotomy (HTO) to those of microfracture with HTO.
    [Knee]

    Abstract

    Assessment of Long-Term In Vitro Multiplied Human Wharton’s Jelly-Derived Mesenchymal Stem Cells prior to Their Use in Clinical Administration

    The authors analyzed cellular, molecular, and chromosomal alterations in Wharton’s jelly-derived MSCs during their in vitro sequential passages.
    [Cells Tissues Organs]

    Abstract

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    REVIEWS

    Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases

    Investigators provide an overview of humab bone-marrow-MSCs, the application of these cells to various neurological diseases, and improvements in their quality and freshness based on integrated omics after detachment from the culture dish for successful cell therapy.
    [Stem Cell International]

    Full Article

    Mesenchymal Stem Cell Therapy for Alzheimer’s Disease

    The authors compile pertinent preclinical Alzheimer’s disease research on transgenic mice as well as clinical trials on MSC-based therapy from diverse sources.
    [Stem Cells International]

    Full Article

    INDUSTRY AND POLICY NEWS

    Researchers Awarded $31 Million for Clinical Trials to Treat Stroke, Heart Failure, Brain Cancer

    The California Institute for Regenerative Medicine has awarded $31 million to three Stanford researchers to launch trials of treatments for common diseases. Four other Stanford researchers also received a total of $4.55 million.
    [Stanford Medicine]

    Press Release

    FEATURED EVENT

    AACR Virtual Meeting: Precision Medicine Strategies to Improve Therapy of Diffuse Large B-Cell Lymphoma

    September 30 – October 1, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Head of Laboratory – Cellular Therapies

    NHS Blood and Transplant – Oxford, England, United Kingdom

    Postdoctoral Position – Stem Cells and Disease Modeling

    King Abdullah University of Science and Technology – Thuwal, Saudi Arabia

    Scientist – Mesenchymal Stem Cell Lineages

    Broad Institute – Cambridge, Massachusetts, United States

    Research Associate – Organogenesis, Stem Cells, and Regenerative Medicine

    University of Southern California – Los Angeles, California, United States

    Postdoctoral Fellow – Hematopoietic and Mesenchymal Cells

    Lund University – Lund, Sweden

    > See All Jobs

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