Cord Blood News Volume 13.36 | Oct 7 2021

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    2021-10-07 | CBN 13.36


    Cord Blood News by STEMCELL Technologies
    Vol. 13.36 – 7 October, 2021
    TOP STORY

    Blood and Immune Development in Human Fetal Bone Marrow and Down Syndrome

    Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.
    [Nature]

    AbstractPress Release

    Attend the Keystone Symposia: Maternal-Fetal Newborn Immunity!
    PUBLICATIONSRanked by the impact factor of the journal

    Small Intestinal Submucosa Membrane Modified by Fusion Peptide-Mediated Extracellular Vesicles to Promote Tissue Regeneration

    Extracellular vesicles (EVs) derived from umbilical cord MSCs could achieve rapid cell proliferation and migration with little immune response by creating a satisfactory microenvironment. Fusion peptide-mediated EVs were able to modify the surface of the small intestinal submucosa membrane via specific combination.
    [Advanced Healthcare Materials]

    Abstract

    Management of Toxic Optic Neuropathy via a Combination of Wharton’s Jelly-Derived Mesenchymal Stem Cells with Electromagnetic Stimulation

    Researchers investigated the effect of the combination of Wharton’s jelly derived MSCs and high frequency repetitive electromagnetic stimulation in the therapy of toxic optic neuropathies with severe symptoms after the available current therapy modalities which were unsucessful.
    [Stem Cell Research & Therapy]

    Full Article

    Haploidentical vs. Sibling, Unrelated, or Cord Blood Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia

    Scientists compared overall survival between haploidentical hematopoietic cell transplantation (HCT) using post-transplant cyclophosphamid and HLA-matched sibling donor, 8/8 HLA-matched unrelated donor, 7/8 HLA-matched unrelated donor, or umbilical cord blood HCT.
    [Blood Advances]

    Abstract

    Altered Effect of Killer Immunoglobulin-Like Receptor–Ligand Mismatch by Graft versus Host Disease Prophylaxis in Cord Blood Transplantation

    The difference in the effect of killer immunoglobulin-like receptor–ligand mismatch was retrospectively assessed between patients who received cord blood transplantation for acute leukemia, myelodysplastic syndrome, or chronic myeloid leukemia, as well as graft versus host disease prophylaxis comprising tacrolimus plus methotrexate or mycophenolate mofetil.
    [Bone Marrow Transplantation]

    Abstract

    Metformin Enhances the Osteogenesis and Angiogenesis of Human Umbilical Cord Mesenchymal Stem Cells for Tissue Regeneration Engineering

    Researchers explored the effects of metformin on the osteogenesis, adipogenesis and angiogenesis of human umbilical cord-MSCs, and attempted to explain the molecular fluctuations of metformin through the mapping of protein profiles.
    [International Journal of Biochemistry & Cell Biology]

    AbstractGraphical Abstract

    Total Body Irradiation-Containing Conditioning Regimens without Antithymocyte Globulin in Adults with Aplastic Anemia Undergoing Umbilical Cord Blood Transplantation

    The authors compared transplantation outcomes between a fludarabine (Flu)- and melphalan-based regimen and a Flu- and cyclophosphamide-based regimen
    [Annals of Hematology]

    Abstract

    Amniotic Fluid Stem Cell Administration Can Prevent Epithelial Injury from Necrotizing Enterocolitis

    Investigators examined the effects of amniotic fluid and mesenchymal stem cells on the prevention of intestinal injury during experimental necrotizing enterocolitis.
    [Pediatric Research]

    Abstract

    Titers of SARS CoV-2 Antibodies in Cord Blood of Neonates Whose Mothers Contracted SARS CoV-2 (COVID-19) during Pregnancy and in Those Whose Mothers Were Vaccinated with mRNA to SARS CoV-2 during Pregnancy

    Scientists compared neonatal immunity after vaccination against SARS-CoV-2 during pregnancy to that achieved after maternal infection.
    [Journal of Perinatology]

    Abstract

    Involvement of Various Chemokine/Chemokine Receptor Axes in Trafficking and Oriented Locomotion of Mesenchymal Stem Cells in Multiple Sclerosis Patients

    Researchers hypothesized that the chemokine/chemokine receptor axes network had crucial and efficacious impacts on behavior of the MSCs.
    [Cytokine]

    Abstract

    Get High Cell Purity and Recovery with Lymphoprepâ„¢
    REVIEWS

    Stem Cell Therapy in Liver Regeneration: Focus on Mesenchymal Stem Cells and Induced Pluripotent Stem Cells

    Owing to the recent developments in mesenchymal stem cells and induced pluripotent stem cells, combined with emerging technologies including graphene, nano-biomaterials, and gene editing, precision medicine and individualized clinical treatment may be realized in the near future.
    [Pharmacology & Therapeutics]

    Abstract

    INDUSTRY AND POLICY NEWS

    UC Riverside Receives $5M CIRM Grant to Train Scientists in Stem Cell Research

    The University of California, Riverside, has received a grant of $5 million from the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians in stem cell research.
    [University of California, Riverside]

    Press Release

    UCLA Broad Stem Cell Research Center Receives $5 Million CIRM Grant for Research Training Program

    The Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA has been awarded $5 million by the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians to become leaders in the stem cell and regenerative medicine field.
    [University of California]

    Press Release

    FEATURED EVENT

    The NYSCF Conference – New York Stem Cell Foundation

    October 19 – 20, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Computational Biology of Sarcomas

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Research Associate – Cell Proliferation

    Imperial College London – London, England, United Kingdom

    Faculty Position – Hematopoiesis and Hematologic Malignancies

    The University of Kansas – Kansas City, Kansas, United States

    Postdoctoral Position – Stem Cells and Disease Modeling

    King Abdullah University of Science and Technology – Thuwal, Saudi Arabia

    Research Associate – Organogenesis, Stem Cells, and Regenerative Medicine

    University of Southern California – Los Angeles, California, United States

    > See All Jobs

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