Cord Blood News Volume 13.38 | Oct 21 2021

    0
    89







    2021-10-21 | CBN 13.38


    Cord Blood News by STEMCELL Technologies
    Vol. 13.38 – 21 October, 2021
    TOP STORY

    Maternal SARS-CoV-2 Infection Elicits Sexually Dimorphic Placental Immune Responses

    Investigators examined the intersection of maternal-fetal antibody transfer, viral-induced placental interferon responses, and fetal sex in pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
    [Science Translational Medicine]

    Full ArticlePress Release
    Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.
    PUBLICATIONSRanked by the impact factor of the journal

    The Treasury of Wharton’s Jelly

    Researchers investigated very small embryonic-like cells (VSELs)-like cells in terms of their pluripotency phenotype and tri-lineage differentiation potential.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infant

    Scientists analyzed lymphocyte receptor repertoires in maternal and cord blood from 14 term and 10 preterm deliveries, hypothesizing that the high prevalence of infection in patients with preterm labor may have resultee in specific changes in the T cell and B cell repertoires.
    [Journal of Immunology]

    AbstractFull Article

    Preclinical Assessment of Thrombin-Preconditioned Human Wharton’s Jelly-Derived Mesenchymal Stem Cells for Neonatal Hypoxic-Ischaemic Brain Injury

    The authors evaluated the tissue distribution and potential toxicity of thrombin-preconditioned human Wharton’s jelly-derived MSCs in animal models before the initiation of clinical trials.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Development of Injectable Graphene Oxide/Laponite/Gelatin Hydrogel Containing Wharton’s Jelly Mesenchymal Stem Cells for Treatment of Oxidative Stress-Damaged Cardiomyocytes

    An injectable graphene oxide (GO)/laponite/gelatin (GO-LG) hydrogel was developed and characterized. The results of cell viability showed that the optimal concentration of GO flasks to treat cells was 100 μg/ml.
    [Colloids and Surfaces B-Biointerfaces]

    AbstractGraphical Abstract

    Dimethyl Sulfoxide-Free Cryopreservation Solutions for Hematopoietic Stem Cell Grafts

    Investigators compared the capacity of four dimethyl sulfoxide (DMSO)-free freezing media to cryopreserve cord blood hematopoietic stem cells: CryoProtectPureSTEM, CryoScarless, CryoNovo P24 and Pentaisomaltose. Clinical-grade DMSO/dextran solution was used as control.
    [Cytotherapy]

    Abstract

    miR-3065-3p Promotes Stemness and Metastasis by Targeting CRLF1 in Colorectal Cancer

    The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases.
    [Journal of Translational Medicine]

    Full Article

    Extracellular Vesicles Secreted from Mesenchymal Stem Cells Exert Anti-Apoptotic and Anti-Inflammatory Effects via Transmitting microRNA-18b in Rats with Diabetic Retinopathy

    Scientists investigated the anti-inflammatory properties of small extracellular vesicles derived from human umbilical cord MSCs in a diabetic rat model and human retinal microvascular endothelial cells.
    [International Immunopharmacology]

    Abstract

    Maternal Selenium Deficiency Suppresses Proliferation, Induces Autophagy Dysfunction, Apoptosis in the Placenta of Mice

    Researchers found that maternal selenium (Se) deficiency decreased placental Se concentration and expressions of some antioxidant selenoproteins.
    [Metallomics]

    Abstract
    Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.
    REVIEWS

    DNA Barcode to Trace the Development and Differentiation of Cord Blood Stem Cells

    The latest research findings on the development and differentiation, culture techniques and labeling and tracing of umbilical cord blood stem cells are reviewed.
    [Molecular Medicine Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    ISS National Lab Releases Research Announcement Focused on In-Space Production Applications in Biomanufacturing

    The International Space Station (ISS) National Laboratory has unveiled a research announcement seeking proposals to demonstrate biomanufacturing activities in microgravity.
    [The International Space Station]

    Press Release

    Longeveron Announces Activation of Two New Clinical Sites in ELPIS II Trial of Lomecel-B for Hypoplastic Left Heart Syndrome (HLHS)

    Longeveron, Inc. announced the activation of two new clinical sites for the currently enrolling ELPIS II Trial, evaluating Lomecel-B injection into the myocardium of infants with Hypoplastic Left Heart Syndrome, a rare and life-threatening congenital heart defect.
    [Longeveron, Inc.]

    Press Release
    FEATURED EVENT

    FSSCR French Society for Stem Cell Research

    November 9 – 10, 2021
    Montpellier, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Cell Death

    Duke University – Durham, North Carolina, United States

    Advanced Research Assistant – Human Cell Atlas

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Position – Computational Biology of Sarcomas

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Faculty Position – Hematopoiesis and Hematologic Malignancies

    The University of Kansas – Kansas City, Kansas, United States

    Postdoctoral Position – Stem Cells and Disease Modeling

    King Abdullah University of Science and Technology – Thuwal, Saudi Arabia

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cord Blood News Twitter