Cord Blood News Volume 13.39 | Oct 28 2021

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    Justin.choi
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    2021-10-28 | CBN 13.39


    Cord Blood News by STEMCELL Technologies
    Vol. 13.39 – 28 October, 2021
    TOP STORY

    Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth

    Using mice models and human samples, scientists investigated the physiological requirement for endothelial cell BH4 in uteroplacental vascular adaptation and blood pressure regulation to pregnancy.
    [Hypertension]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    In Utero Exposure to Parabens and Early Childhood BMI Z-Scores – Associations between Placental Ethyl Paraben, Longitudinal BMI Trajectories and Cord Blood Metabolic Biomarkers

    Researchers examined the association between placental paraben levels and cord blood metabolic biomarkers, considering modulating effects of maternal pre-pregnancy BMI and underlying epigenetic mechanisms, and investigated longitudinal effects of in utero paraben exposure on early childhood trajectories of BMI z-scores.
    [Environment International]

    Full ArticleGraphical Abstract

    Activation of the EGFR-PI3K-CaM Pathway by PRL-1-Overexpressing Placenta-Derived Mesenchymal Stem Cells Ameliorates Liver Cirrhosis via ER Stress-Dependent Calcium

    Scientists demonstrated that placenta-derived mesenchymal stem cells improved hepatic functions by regulating endoplasmic reticulum stress and calcium channels in a rat model of bile duct ligation.
    [Stem Cell Research & Therapy]

    Full Article

    Effect of Hepatocyte Growth Factor-Transfected Human Umbilical Cord Mesenchymal Stem Cells on Hepatic Stellate Cells by Regulating Transforming Growth Factor-β1/Smads Signaling Pathway

    Investigators explored the possible mechanism of hepatocyte growth factor-transfectedhuman umbilical cord mesenchymal stem cells in inhibiting the proliferation and activation of hepatic stellate cells-T6.
    [Stem Cells and Development]

    Abstract

    Exosomes Derived from Placental Trophoblast Cells Regulate Endometrial Epithelial Receptivity in Dairy Cows during Pregnancy

    Scientists demonstrated that trophoblast-derived exosome proteins were one of the most critical elements in fetomaternal interaction, and their changes might act as a key signal in altering endometrial receptivity and provided a potential target for improving fertility.
    [Journal of Reproduction and Development]

    AbstractGraphical Abstract

    Comparison of the Cytokine Profile in Mesenchymal Stem Cells from Human Adipose, Umbilical Cord, and Placental Tissues

    MSCs were extracted from adipose, umbilical cord, and placental tissues. The surface marker expression, multilineage differentiation potential and cytokine secretion of these cells were compared.
    [Cellular Reprogramming]

    Abstract

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    REVIEWS

    Umbilical Cord Blood Culture in Neonatal Early-Onset Sepsis: A Systematic Review and Meta-Analysis

    Scientists systematically asses the diagnostic test accuracy of umbilical cord blood culture for early-onset sepsis.
    [Pediatric Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    Cord Blood Banking Leader Cryo-Cell Announces Its Intent to Advance Clinical Trials

    Cryo-Cell International, Inc. acquired exclusive commercial rights to a range of intellectual property assets and FDA regulatory data around several cord blood and cord tissue derived cell therapy products that had completed Phase I/Phase II clinical trials.
    [Cryo-Cell International, Inc. (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    FSSCR French Society for Stem Cell Research

    November 9 – 10, 2021
    Montpellier, France

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Gene Editing

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellowship – Cell Death

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Functional Genomics of Hematopoiesis

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Faculty Position – Hematopoiesis and Hematologic Malignancies

    The University of Kansas – Kansas City, Kansas, United States

    Postdoctoral Position – Stem Cells and Disease Modeling

    King Abdullah University of Science and Technology – Thuwal, Saudi Arabia

    > See All Jobs

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