 | | Vol. 13.41 – 18 November, 2021 |
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| Site-specific mutations were introduced in defined regions of DNMT3A, TET2, and ASXL1 in CD34+ progenitor cells that were subsequently analyzed in short-term as well as long-term in vitro culture assays to assess self-renewal and differentiation capacities.
[Leukemia] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using a combination of bioinformatics and molecular genetics, investigators identified Toxoplasma gondii GRA28 as the gene product required for CCL22 induction.
[mBio] |
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| Scientists revealed that three single nucleotide polymorphisms located in the intron or 3’-UTR of HLA-DOB regions were associated with the survival of patients in the recipient and donor-recipient matching groups, as well as cytomegalovirus infection/reactivation in the donor-recipient matching group.
[Scientific Reports] |
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| Researchers generated and analyzed ChIP-seq data for multiple histone modifications known to mark cis-regulatory regions.
[Scientific Reports] |
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| The authors prepared a functional cell derived extracellular matrix biomaterial enriched with VEGFA and bFGF, which induced endothelial differentiation of human umbilical cord mesenchymal stem cells and promoted angiogenesis, which may improve the healing effect of skin injury.
[Biomedical Materials] |
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| Mice with scleroderma received a single 50 μg human umbilical cord mesenchymal stem cells (HUMSCs)-Ex. HUMSCs-Ex was characterized using transmission electron microscopy, nanoparticle tracking analysis and nanoflow cytometry.
[Tissue Engineering and Regenerative Medicine] |
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| Scientists investigated the specific impacts of umbilical cord mesenchymal stem cells overexpressing miR-455-5p in intrauterine adhesions.
[Bioengineered] |
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| In this review, the gap between the many basic studies and limited clinical trials on stem cell-derived red blood cells and platelets is summarized.
[Stem Cells Translational Medicine] |
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| Endoglin expression is up-regulated in preeclamptic placentas, through mechanisms mainly induced by hypoxia, oxidative stress and oxysterol-mediated activation of liver X receptors.
[Molecular and Cellular Biochemistry] |
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| Vitro Biopharma, Inc. announced receipt of FDA authorization and clearance to enroll patients in its IND for a phase I-II, randomized, double-blind, placebo-controlled study of the safety and efficacy of therapeutic treatment with AlloRx Stem Cells® in children with Pitt Hopkins Syndrome.
[Vitro Biopharma, Inc. (GlobeNewswire, Inc.)] |
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| December 8 – 9, 2021
Virtual |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | University Children’s Hospital Zurich – Zurich, Switzerland |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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