Cord Blood News Volume 13.45 | Dec 16 2021

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    Justin.choi
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    2021-12-16 | CBN 13.45


    Cord Blood News by STEMCELL Technologies
    Vol. 13.45 – 16 December, 2021
    TOP STORY

    Co-Administration of Human MSC Overexpressing HIF-1α Increases Human CD34+ Cell Engraftment In Vivo

    Human cord blood CD34+ cells were co-cultured with mesenchymal stromal cells (MSC) wild type or hypoxia-inducible factor-1α-MSC (4:1) for 72 hours. Viability, cell cycle, ROS expression and immunophenotyping of key molecules involved in engraftment were evaluated by flow cytometry in CD34+ cells.
    [Stem Cell Research & Therapy]

    Full Article

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model

    Investigators manufactured neprilysin gene-enhanced human umbilical cord-derived MSCs and intravenously transplanted them in Aβ1-42-injected Alzheimer’s disease animal models.
    [Stem Cells International]

    Full Article

    Krüppel-Like Factor 6 (KLF6) Requires Its Amino Terminal Domain to Promote Villous Trophoblast Cell Fusion

    Villous cytotrophoblast (vCTB) cells fuse to generate and maintain the syncytiotrophoblast layer required for placental development and function. Scientists demonstrated that KLF6 was necessary for cell fusion in human primary vCTB and in the BeWo cell line.
    [Placenta]

    AbstractGraphical Abstract

    Maternal Obesity Increases DNA Methylation and Decreases RNA Methylation in the Human Placenta

    Scientists revealed that the levels of 5-methylcytosine (5mC), were significantly increased coupled with decreased activity of Ten-Eleven Translocation (TETs) enzymes that principally functioned by oxidizing 5mC in the obese placenta, consistent with hypoxia-induced genome-wide DNA hypermethylation observed in varied types of cells and tissues.
    [Reproductive Toxicology]

    Abstract

    Flavivirus Replication Kinetics in Early-Term Placental Cell Lines with Different Differentiation Pathways

    Researchers evaluated the replication kinetics of Zika virus and the related encephalitic flavivirus West Nile strain Kunjin virus in early-term placental cell lines.
    [Virology Journal]

    Full Article

    Diagnostic Comparison between Cord Blood and Filter Paper for the Screening of Congenital Hypothyroidism

    The study included 21,012 newborn screened babies for congenital hypothyroidism starting from September 2013 until March 2019. Both cord-blood and heel-prick TSH were collected from each newborn.
    [Journal of Clinical Laboratory Analysis]

    Full Article

    Image of man completing the on-demand CFU assay course on his laptop.
    REVIEWS

    Amniotic Fluid Stem Cells: What They Are and What They Can Become

    In the last two decades, fetal amniotic fluid stem cells progressively attracted attention in the context of both basic research and the development of innovative therapeutic concepts.
    [Current Stem Cell Research & Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    FibroBiologics Introduces Scientific Advisory Board

    FibroBiologics, introduced its scientific advisory board (SAB). Comprised of world-renowned scientists and clinicians, the SAB will provide the company with guidance on current and planned development programs focused exclusively on fibroblast-based cell therapies.
    [FibroBiologics, Inc.]

    Press Release

    Essent Biologics and Amnion Foundation Partner to Provide Germinal-Origin Cells to Further Drug Discovery and Regenerative Medicine Research

    Essent Biologics™, announced it has entered into a global distribution partnership agreement with the Amnion Foundation, a non-profit cell bank specializing in birth-tissue related cells and services.
    [Essent Biologics]

    Press Release

    FEATURED EVENT

    The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

    March 9 – 11, 2022
    Melbourne, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scientist – Bioinformatics

    MRC London Institute of Medical Sciences – London, England, United Kingdom

    Clinical Research Manager – Leukemia Clinical Trials

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Scholar Position – Regeneration

    University of Calgary – Calgary, Alberta, Canada

    Research Technician – Hematologic Disorders

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Gene Editing

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    > See All Jobs

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