Cord Blood News Volume 14.02 | Jan 20 2022

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    2022-01-20 | CBN 14.02


    Cord Blood News by STEMCELL Technologies
    Vol. 14.02 – 20 January, 2022
    TOP STORY

    Mapping the Cord Blood Transcriptome of Pregnancies Affected by Early Maternal Anemia to Identify Signatures of Fetal Programming

    Researchers leveraged global transcriptome and accompanying epigenome-wide changes in 48 umbilical cord blood (UCB) from newborns of early pregnancy (EP)-anemic Tanzanian mothers and 50 controls to identify differentially expressed genes in UCB exposed to maternal EP-anemia.
    [Journal of Clinical Endocrinology & Metabolism]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Expression of Tissue Factor and TF-Mediated Integrin Regulation in HTR-8/SVneo Trophoblast Cells

    Scientists ascertained the expression of tissue factor in a HTR-8/SVneo trophoblast cell line and its role in signal transduction of integrin regulation concerning the invasion of trophoblasts.
    [Journal of Reproductive Immunology]

    Abstract

    Asymmetric Expression of Proteins in the Granules of the Placentomal Binucleate Cells in Giraffa camelopardalis

    Gold labelled lectin histochemistry and protein immunocytochemistry were used on deplasticised 1 μm sections of a wide variety of ruminant placentomes with a wide range of antibodies and lectins.
    [Biology of Reproduction]

    Abstract

    Silencing of Nrf Genes in the Human Placenta as Measured by SDS-PAGE and Western Blotting Techniques

    Scientists reported the presence of nuclear factor erythroid 2-related factor (Nrf)1, Nrf2 and Nrf3 proteins in both human primary trophoblast and human trophoblast choriocarcinoma cell line.
    [Placenta]

    Abstract

    The Effect of Progesterone Administration on the Expression of Metastasis Tumor Antigens (MTA1 and MTA3) in Placentas of Normal and Dexamethasone-Treated Rats

    MTA1 upregulates trophoblasts proliferation and differentiation, while MTA3 downregulates proliferation and induces apoptosis. Researchers hypothesized that during intrauterine growth restriction, placental MTA1 decreased and MTA3 increased and this was reversed by P4 treatment.
    [Molecular Biology Reports]

    Abstract

    Relationship between Donor-Specific HPA-15 Antibodies and Poor Graft Function in HPA-15 Mismatched Cord Blood Transplantation

    Investigators encountered a case of human platelet antigen 15 (HPA-15) mismatched cord blood transplantation with a high HPA-15b antibody titer. Prolonged poor graft function and megakaryocyte aplasia with sustained high-titer HPA-15b antibodies were attenuated by rituximab therapy.
    [International Journal of Hematology]

    Abstract

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    REVIEWS

    Applications of the Amniotic Membrane in Tissue Engineering and Regeneration: The Hundred-Year Challenge

    Scientists highlight the development of the amniotic-membrane over the years and the implication of new and emerging nanotechnology to support expanding its use for tissue engineering and clinical applications.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    The Placenta as a Target of Opioid Drugs

    The authors discuss the current human and rodent studies that have examined the effects of opioids on the placenta.
    [Biology of Reproduction]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    IMV Announces First Patient Dosed in the VITALIZE Phase IIB Clinical Study Evaluating its Lead Compound, MVP-S, in Combination with KEYTRUDA® (pembrolizumab) in Patients with r/r DLBCL

    IMV, Inc., a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, announced a first patient dosed in the VITALIZE Phase IIB clinical trial.
    [IMV, Inc.]

    Press Release

    FEATURED EVENT

    Nature Conference – Breaking Barriers for Gender Equity Through LEAP

    8 March, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Metabolomics/Proteomics

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Position – Computational Biology

    Harvard Medical School – Boston, Massachusetts, United States

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Associate – Molecular and Cellular Biology

    Baylor College of Medicine – Houston, Texas, United States

    Clinical Research Manager – Leukemia Clinical Trials

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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