Cord Blood News Volume 14.03 | Jan 27 2022

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    2022-01-27 | CBN 14.03


    Cord Blood News by STEMCELL Technologies
    Vol. 14.03 – 27 January, 2022
    TOP STORY

    Human Placental Mesenchymal Stromal Cells Are Ciliated and Their Ciliation Is Compromised in Preeclampsia

    Scientists determined whether human chronic villi-mesenchymal stromal cells (hCV-MSCs) were ciliated and whether altered ciliation was responsible for defective hCV-MSCs in preeclamptic placentas, as the primary cilium was a hub for signal transduction, which was important for various cellular activities.
    [BMC Medicine]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation

    The authors cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Isolation and Culture of Decidual Natural Killer Cells from Term Placenta and Complete Hydatidiform Mole

    A novel protocol was developed to isolate and culture decidual natural killer cells cells from fresh, term placentas and complete hydatidiform moles.
    [Journal of Reproductive Immunology]

    Full Article

    Impact of Reduced Uterine Perfusion Pressure Model of Preeclampsia on Metabolism of Placenta, Maternal and Fetal Hearts

    Researchers examined the impact of the reduced uterine perfusion pressure rat model of preeclampsia on the maternal cardiovascular system, placental and fetal heart metabolism.
    [Scientific Reports]

    Full Article

    Identification of Differentially Methylated Genes in First-Trimester Placentas with Trisomy 16

    Trisomy 16 is the most common aneuploidy in first-trimester miscarriages. Scientists identified changes in DNA methylation in chorionic villi of miscarriages with trisomy 16.
    [Scientific Reports]

    Full Article

    Long Non-Coding RNA ZEB2-AS1 Augments Activity of Trophoblast Cells and Prevents the Development of Recurrent Spontaneous Abortion in Mice through EZH2-Mediated CST3 Inhibition

    Scientists explored the effect of abnormally expressed long non-coding RNA ZEB2-AS1 on the occurrence of recurrent spontaneous abortion.
    [Reproductive Sciences]

    Abstract

    Targeted Newborn Metabolomics: Prediction of Gestational Age from Cord Blood

    Researchers determined whether metabolites from a retrospective collection of banked cord blood specimens could accurately estimate gestational age and validated these findings in cord blood samples from Busia, Uganda.
    [Journal of Perinatology]

    Abstract


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    REVIEWS

    On-Going Consequences of In Utero Exposure of Pb: An Epigenetic Perspective

    The authors review currently available information on lead (Pb)-mediated alterations in the fetal epigenome is summarized.
    [Journal of Applied Toxicology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Celularity Receives Fast Track Designation from US FDA for Its NK Cell Therapy CYNK-101 in Development for the First-Line Treatment of Advanced HER2/Neu Positive Gastric and Gastroesophageal Junction Cancers

    Celularity Inc. announced the US FDA has granted Fast Track Designation for its genetically modified cryopreserved human placental hematopoietic stem cell-derived natural killer (NK) cell therapy, CYNK-101, which is being developed in combination with standard chemotherapy, trastuzumab and pembrolizumab in patients in first-line locally advanced unresectable or metastatic HER2/neu positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
    [Celularity, Inc.]

    Press Release

    FEATURED EVENT

    European Society for Blood and Marrow Transplant (EBMT)

    March 19 – 23, 2022
    Prague, Czech Republic & Online

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    JOB OPPORTUNITIES

    Postdoctoral Scholar – Pediatric Hematology

    Penn State College of Medicine – Hershey, Pennsylvania, United States

    Research Associate – Metabolomics/Proteomics

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Position – Computational Biology

    Harvard Medical School – Boston, Massachusetts, United States

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Associate – Molecular and Cellular Biology

    Baylor College of Medicine – Houston, Texas, United States

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