Cord Blood News Volume 14.04 | Feb 3 2022

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    2022-02-03 | CBN 14.04


    Cord Blood News by STEMCELL Technologies
    Vol. 14.04 – 3 February, 2022
    TOP STORY

    HGF Secreted by Mesenchymal Stromal Cells Promotes Primordial Follicle Activation by Increasing the Activity of the PI3K-AKT Signaling Pathway

    The authors revealed that treatment with the human umbilical cord mesenchymal stromal cells significantly increased the proportion of activated primordial follicles in mouse ovaries both in vitro and in vivo.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract
    ON987CXN-feb-728x90-2022
    PUBLICATIONSRanked by the impact factor of the journal

    Generation and Characterization of Human Umbilical Cord Blood-Derived Induced Pluripotent Stem Cells (KRIBBi005-A)

    Researchers reprogrammed CD34+-umbilical cord blood cells with the group O/D-negative blood type as a universal source for red blood cell generation.
    [Stem Cell Research]

    Abstract

    Prevention of Chronic Diabetic Complications in Type 1 Diabetes by Co-transplantation of Umbilical Cord Mesenchymal Stromal Cells and Autologous Bone Marrow: A Pilot Randomized Controlled Open-Label Clinical Study with 8-Year Follow-Up

    Scientists revealed that co-transplantation of umbilical cord mesenchymal stromal cells and autologous bone marrow mononuclear cells in patients with established type 1 diabetes was associated with reduced incidence of chronic diabetes complications.
    [Cytotherapy]

    Abstract

    Therapeutic Effects of Mesenchymal Stem Cells Loaded with Oncolytic Adenovirus Carrying Decorin on a Breast Cancer Lung Metastatic Mouse Model

    Investigators loaded umbilical cord-derived MSCs with oncolytic adenoviruses expressing decorin or without foreign genes to treat breast cancer lung metastasis.
    [Molecular Therapy Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Cytosolic dsRNA Improves Neonatal Innate Immune Responses to Adjuvants in Use in Pediatric Vaccines

    Researchers showed that myeloid cells from cord blood could be activated to express T cell costimulatory markers, and also to produced Th1 promoting cytokines.
    [Journal of Leukocyte Biology]

    Full Article

    Acute SARS-CoV-2 Infection in Pregnancy Is Associated with Placental ACE2 Shedding

    Scientists evaluated angiotensin-converting enzyme-2 (ACE2) expression, a disintegrin and metalloprotease domain 17 activity and serum ACE2 abundance in a cohort of matched villous placental and maternal serum samples from control pregnancies and pregnancies affected by symptomatic maternal SARS-CoV-2 infections in the 2nd trimester and 3rd trimester.
    [American Journal of Pathology]

    Full Article

    Transcriptomic Analysis of Functional Diversity of Human Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells in Erythroid Differentiation

    Researchers compared the erythroid potential of CD34+ hematopoietic stem and progenitor cells from 50 different umbilical cord blood donors and discovered that those donors gave rise to diverse frequencies of Glycophorin-A+ erythroid cells after in vitro differentiation, despite having similar frequencies of phenotypic hematopoietic stem cells initially.
    [International Journal of Hematology]

    Abstract
    Cell Preparation For Crossmatch Assays
    REVIEWS

    Proteomic Profile of Extracellular Matrix from Native and Decellularized Chorionic Canine Placenta

    The authors studied the proteome profiled of canine native and decellularized placenta to characterize the proteome related to maintenance of a microenvironment and structure suitable for tissue engineering applications.
    [Journal of Proteomics]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Leonhardt Ventures Announces Launch of Research Program Using Patent Pending Klotho Expressing Mesenchymal Stem Cells for Multiple Applications in Combination with Bioelectric Protein Expressions

    Leonhardt Ventures LLC announced that it has begun an active research program to combine its patent-pending klotho expression bioelectric stimulation technologies with newly acquired klotho expressing MSC technology.
    [Leonhardt Ventures (Globe Newswire, Inc.)]

    Press Release
    FEATURED EVENT

    British Society for Developmental Biology (BSDB) Annual Spring Meeting

    April 3 – 6, 2022
    Warwick, England, United Kingdom

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    JOB OPPORTUNITIES

    Postdoctoral Position – Regenerative Medicine

    Stanford University – Stanford, California, United States

    Postdoctoral Scholar – Pediatric Hematology

    Penn State College of Medicine – Hershey, Pennsylvania, United States

    Research Associate – Metabolomics/Proteomics

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Position – Computational Biology

    Harvard Medical School – Boston, Massachusetts, United States

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    > See All Jobs

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