Cord Blood News Volume 14.06 | Feb 17 2022

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    2022-02-17 | CBN 14.04


    Cord Blood News by STEMCELL Technologies
    Vol. 14.04 – 17 February, 2022
    TOP STORY

    Placental Methylome Reveals a 22q13.33 Brain Regulatory Gene Locus Associated with Autism

    Investigators used whole genome bisulfite sequencing in placenta samples from prospective autism spectrum disorder (ASD) studies to discover a previously uncharacterized ASD risk gene, LOC105373085, renamed NHIP.
    [Genome Biology]

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    Placental Pathology Predicts Infantile Neurodevelopment

    The authors investigated the association of placental pathological findings with infantile neurodevelopment during the early 40 months of life. For obtaining placental blocks, scientists carried out random sampling and assessed eleven pathological findings using mixed modeling.
    [Scientific Reports]

    Full Article

    Diminished Trophoblast Differentiation in Early Onset Preeclampsia

    Researchers determined whether expression of epithelial-mesenchymal transition-associated genes in the extravillous trophoblast cells of early onset preeclamptics shows a less mesenchymal, more epithelial phenotype compared to control pregnancies.
    [Placenta]

    Abstract
    Graphical Abstract

    Group B Streptococci Infection Model Shows Decreased Regulatory Capacity of Cord Blood Cells

    Scientists investigated the reaction of cord blood mononuclear cells (MNC) to stimulation with group B streptococcus (GBS) in comparison to that of MNC from adult blood with focus on the proliferative response in an in vitro infection model with heat-inactivated GBS.
    [Pediatric Research]

    Abstract

    Intravenous Administration of Human Mesenchymal Stem Cells Derived from Adipose Tissue and Umbilical Cord Improves Neuropathic Pain via Suppression of Neuronal Damage and Anti-Inflammatory Actions in Rats

    The authors investigated the effects of human adipose tissue and umbilical cord-mesenchymal stem cells on neuropathic pain and its mechanisms using rat models of partial sciatic nerve ligation.
    [PLoS One]

    Full Article

    Human Umbilical Cord Mesenchymal Stem Cells Alleviate the Imbalance of CD4+ T Cells via Protein Tyrosine Phosphatase Non-Receptor Type 2/Signal Transducer and Activator of Transcription 3 Signaling in Ameliorating Experimental Autoimmune Thyroiditis

    Human umbilical cord mesenchymal stem cells treatment significantly alleviated inflammation, reduced serum thyroid antibody levels, and decreased the ratios of IL-17α+/CD25+FOXP3+ cells and serum IFN-γ/IL-4 in experimental autoimmune thyroiditis rats.
    [Endocrine Journal]

    AbstractFull Article

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    REVIEWS

    Umbilical Cord Blood-Derived Exosomes in Maternal–Fetal Disease: A Review

    Investigators summarize specific functions and research directions regarding umbilical cord blood-derived exosomes, and their potential associations with pregnancy complications.
    [Reproductive Sciences]

    Abstract

    INDUSTRY AND POLICY NEWS

    IMAC Holdings, Inc. Announces Completion of Second Cohort of Its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

    IMAC Holdings, Inc. announced that it has completed the second cohort of its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic mesenchymal stem cells for the treatment of bradykinesia due to Parkinson’s disease.
    [IMAC Holdings, Inc.]

    Press Release

    FEATURED EVENT

    Antibody Biology and Engineering

    March 13 – 18, 2022
    Ventura, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Cell Viability

    Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore

    Postdoctoral Research Fellow – Virology

    George Mason University – Prince William, Virginia, United States

    Postdoctoral Position – Regenerative Medicine

    Stanford University – Stanford, California, United States

    Postdoctoral Scholar – Pediatric Hematology

    Penn State College of Medicine – Hershey, Pennsylvania, United States

    Research Associate – Metabolomics/Proteomics

    Albert Einstein College of Medicine – Bronx, New York, United States

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