Cord Blood News Volume 14.09 | Mar 10 2022

    0
    78







    2022-03-10 | CBN 14.09


    Cord Blood News by STEMCELL Technologies
    Vol. 14.09 – 10 March, 2022
    TOP STORY

    Differential Expression of Placental 11β-HSD2 Induced by High Maternal Glucocorticoid Exposure Mediates Sex Differences in Placental and Fetal Development

    Researchers investigated the effects of prenatal caffeine exposure-induced high maternal glucocorticoid level on placental and fetal development by regulating placental 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) expression and its underlying mechanism.
    [Science of the Total Environment]

    AbstractGraphical Abstract
    Get High Cell Purity and Recovery with Lymphoprep™
    PUBLICATIONSRanked by the impact factor of the journal

    Association of Hyperglycaemia with the Placenta of GDM-Induced Macrosomia with Normal Pre-pregnancy BMI and the Proliferation of Trophoblast Cells

    The authors identified the effect of hyperglycemia on placentas of gestational diabetes mellitus (GDM) women with macrosomia and normal pre-pregnancy body mass index (BMI), and uncover the molecular mechanism of hyperglycemia on trophoblast cells in vitro.
    [American Journal of Obstetrics and Gynecology]

    Abstract

    Human Umbilical Cord Mesenchymal Stem Cell Promotes Angiogenesis via Integrin β1/ERK1/2/HIF-1α/VEGF-A Signaling Pathway for Off-the-Shelf Breast Tissue Engineering

    Allogenic human umbilical cord MSCs were injected into transplanted fat tissue with or without breast scaffolds as an alternative for breast tissue engineering in vivo, and its potential mechanism of angiogenesis in vitro was explored.
    [Stem Cell Research & Therapy]

    Full Article

    Increased Phosphatase Regenerating Liver-1 Trigger Vascular Remodeling in Injured Ovary via Platelet-Derived Growth Factor Signaling Pathway

    Investigators examined whether by phosphatase regenerating liver-1overexpressed placental-derived-MSCs could maximize the angiogenic effects in ovarian tissues injured of a rat model with partial ovariectomy.
    [Stem Cell Research & Therapy]

    Full Article

    Predictors and Outcomes of Flares in Chronic Graft-versus-Host Disease

    In 145 adult recipients developing chronic graft-versus-host disease (cGVHD) after matched sibling or umbilical cord blood donor hematopoietic cell transplantation from 2010 to 2018, two-year cumulative incidence of flares after cGVHD diagnosis was estimated at 60%, with median time-to-first flare of 188 days.
    [Bone Marrow Transplantation]

    Abstract

    Effects of Polycyclic Aromatic Hydrocarbons on the Proliferation and Differentiation of Placental Cells

    Investigators showed that anthracene, benzofluoranthene, benzopyrene, and 4,4-(9-fluorenylidene)diphenol—a bisphenol A substitute—affected cell viability and necrosis in the placental cell line.
    [Reproductive Biology and Endocrinology]

    Full ArticleGraphical Abstract
    Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.
    REVIEWS

    Umbilical Cord Blood and Cord Tissue-Derived Cell Therapies for Neonatal Morbidities: Current Status and Future Challenges

    The authors present a systematic review of published and registered clinical trials of umbilical cord blood and cord tissue-derived cell therapies for neonatal morbidities.
    [Stem Cells Translational Medicine]

    Abstract

    Extracellular Vesicles as Theranostic Tools in Kidney Disease

    Extracellular vesicles derived from reparative cells, such as MSCs , tubular epithelial progenitor cells, and human umbilical cord blood represent promising regenerative tools for the treatment of kidney diseases.
    [Critical Journal of the American Society of Nephrology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Clarkson University Chemical & Biomolecular Engineering Prof Receives $200K NSF Grant

    Clarkson University Assistant Professor of Chemical & Biomolecular Engineering Bethany Almeida has received a $200,000 National Science Foundation (NSF) Engineering Research Initiation grant.
    [Clarkson University]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting

    April 7 – April 9, 2022
    Rome, Italy & Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Engineer – Bioprinted Tissue Therapeutics

    Aspect Biosystems – Vancouver, British Columbia, Canada

    Faculty Position – Hematopathology

    University of Vermont – Burlington, Vermont, United States

    Postdoctoral Scholar – Pediatric Hematology

    Penn State College of Medicine – Hershey, Pennsylvania, United States

    Research Assistant – Stem Cells and Regenerative Medicine

    King’s College London – London, England, United Kingdom

    Postdoctoral Associate – Cell Viability

    Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cord Blood News Twitter