 | | Vol. 14.10 – 17 March, 2022 |
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| Scientists developed an implantation-on-a-chip that was capable of reconstructing the 3D structural organization of the maternal-fetal interface to model the invasion of specialized fetal extravillous trophoblasts into the maternal uterus.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established that identification of the comprehensive miRNA targetome within primary cells enabled discovery of genes and molecular networks underpinning stemness properties of normal and leukemic cells.
[Cell Reports] |
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| Researchers described a protocol that can be adopted by those seeking to create clinical-grade induced pluripotent stem cells from banked cord blood. Cells were maintained in a feeder-free, xeno-free environment, using fully defined, commercially available reagents.
[Frontiers in Cell and Developmental Biology] |
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| Investigators examined whether phosphatase regenerating liver-1, overexpressed placental-derived-MSCs, could maximize the angiogenic effects in ovarian tissues injured of a rat model with partial ovariectomy.
[Stem Cell Research & Therapy] |
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| The authors studied the functions of umbilical cord MSCs-released extracellular vesicles and their implicated molecules in mesangial proliferative glomerulonephritis.
[Cell Communication and Signaling] |
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| Investigators gained insight into the cell type-specific transcriptomic changes by performing unbiased single-cell RNA sequencing of placental tissue samples, including those of patients diagnosed with preeclampsia and matched healthy controls.
[Molecules and Cells] |
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| Scientists studied the effects of miR-127-3p-enriched extracellular vesicles on choriocarcinoma and underlying mechanisms.
[Experimental Cell Research] |
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| Investigators showed that anthracene, benzofluoranthene, benzopyrene, and 4,4-(9-fluorenylidene)diphenol — a bisphenol A substitute — affected cell viability and necrosis in the placental cell line.
[Reproductive Biology and Endocrinology] |
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| Scientists attempted to characterize the specificity of antibodies isolated from placentas of women with healthy pregnancy and preeclampsia and found that the repertoire of placental antibodies was significantly less variable and qualitatively different from the peripheral blood.
[Scandinavian Journal of Immunology] |
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| The authors discuss derangements to fetal membrane cells in response to both endogenous and exogenous factors to generate inflammatory signals.
[Immunological Reviews] |
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| Extracellular vesicles derived from reparative cells, such as MSCs, tubular epithelial progenitor cells, and human umbilical cord blood represent promising regenerative tools for treatment of kidney diseases.
[Critical Journal of the American Society of Nephrology] |
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| Scientists at Swansea University have launched a major study to discover how everyday pollutants impact the development and health of fetuses and children, such as from wood burning stoves, clothing, cleaning products, and outdoor pollution such as traffic fumes.
[Swansea University] |
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| The Grayson-Jockey Club Research Foundation announced $1,661,180 to fund 15 new equine projects, 10 continuing projects and three career development awards for equine researchers.
[Equine Network, LLC] |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | Penn State College of Medicine – Hershey, Pennsylvania, United States |
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| | King’s College London – London, England, United Kingdom |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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