Cord Blood News Volume 14.12 | Mar 31 2022

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    Justin.choi
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    2022-03-31 | CBN 14.12


    Cord Blood News by STEMCELL Technologies
    Vol. 14.12 – 31 March, 2022
    TOP STORY

    Functional Antagonism between ΔNp63α and GCM1 Regulates Human Trophoblast Stemness and Differentiation

    The authors demonstrated that the induction efficiency of cytotrophoblast was determined by functional antagonism of the placental transcription factor glial cells missing 1 (GCM1) and the stemness regulator ΔNp63α.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Placental Colonization by Fusobacterium nucleatum Is Mediated by Binding of the Fap2 Lectin to Placentally Displayed Gal-GalNAc

    Using peanut agglutinin, investigators demonstrated that the level of Gal-GalNAc found on trophoblasts facing entering maternal blood rose during gestation and was recognized by the fusobacterial Fap2 Gal-GalNAc lectin.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Psoriasis-Like Dermatitis by Suppressing IL-17-Producing γδ T Cells

    Human umbilical cord-derived MSCs were subcutaneously injected into mice with imiquimod-induced psoriasis-like skin inflammation to explore the feasibility of this cellular therapy.
    [Cell and Tissue Research]

    AbstractGraphical Abstract

    Impact of Tissue Processing on Microbiological Colonization in the Context of Placentophagy

    The authors investigated the potential neonatal health risks of a mother’s postpartum ingestion of raw or processed placental tissue, focusing on microbial colonization of processed placenta preparations with potentially pathogenic bacteria Streptococcus agalactiae and Escherichia coli.
    [Scientific Reports]

    Full Article

    Identification of a Novel Gene Signature in Second-Trimester Amniotic Fluid for the Prediction of Preterm Birth

    Cell-free nucleic acids of amniotic fluid supernatant in the early second trimester before the onset of symptoms of preterm birth were analyzed, and researchers compared gene expression levels between spontaneous preterm birth and term birth groups using sequencing analysis.
    [Scientific Reports]

    Full Article

    Inducible Knockout of Syncytin-A Leads to Poor Placental Glucose Transport in Mice

    Abnormal fetal growth, especially fetal growth restriction, is associated with the decreased expression of glucose transporters. Scientists determined the role of syncytin in fetal growth restriction in placental glucose transport capacity.
    [Placenta]

    Abstract

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    REVIEWS

    Human Placenta-Derived Amniotic Epithelial Cells as a New Therapeutic Hope for COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS) and Systemic Inflammation

    Investigators focus on the proposed early and late therapeutic mechanisms of human amniotic epithelial cells and their exosomes to the injured organs.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome

    The authors summarize current evidence from in vitro studies, animal models, and their clinical experience, to support stromal cell therapy in multiple clinical indications.
    [Frontiers in Immunology]

    Full Article

    Cutting the Umbilical Cord: Cancer Stem Cell-Targeted Therapeutics

    Scientists discuss a brief yet functional idea of emerging concepts in cancer stem cell biology to develop efficient therapeutics acting on cancer recurrence and metastasis.
    [Life Sciences]

    Abstract

    INDUSTRY AND POLICY NEWS

    AlloVir Initiates Global Phase III Registrational Study of Posoleucel for Prevention of Life-Threatening Viral Infections from Six Common Viruses in High-Risk, Allogeneic Hematopoietic Cell Transplant Patients

    AlloVir announced the initiation of a Phase III registrational study of posoleucel, an allogeneic, off-the-shelf, multi-virus-specific T-cell therapy, for the prevention of clinically significant infections and end-organ diseases from six potentially life-threatening viruses.
    [AlloVir, Inc.]

    Press Release

    FEATURED EVENT

    SSCN Swiss Stem Cell Network

    May 9, 2022
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellow Position – Translational Research

    Stanford University – Stanford, California, United States

    Postdoctoral Positions – Epigenetics of Stem Cells, Development and Cancer

    Albert Einstein College of Medicine – Bronx, New York, United States

    Faculty Position – Tissue Engineering

    Mayo Clinic – Jacksonville, Florida, United States

    Principal Scientific Researcher – Cell and Tissue Genomics

    Genentech, Inc. – South San Francisco, California, United States

    Research Engineer – Bioprinted Tissue Therapeutics

    Aspect Biosystems – Vancouver, British Columbia, Canada

    > See All Jobs

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