 | | Vol. 14.14 – 14 April, 2022 |
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| Scientists created a single-cell transcriptome map of human hematopoietic tissues from the first trimester to birth and found that the hematopoietic stem cell (HSC) signature RUNX1+HOXA9+MLLT3+MECOM+HLF+SPINK2+ distinguished HSCs from progenitors throughout gestation.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated the effects of CYNK-001, human placental hematopoietic stem cell-derived natural killer cells that exhibited strong cytolytic activity against a range of malignant cells and expressed high levels of activating receptors, against influenza A virus infections.
[Human Vaccines & Immunotherapeutics] |
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| Researchers studied the proferroptosis effect and mechanism of MSC-exosome in hepatic stellate cells.
[Cell Death & Disease] |
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| Scientists investigated whether the combination of melatonin and human umbilical cord (hUC) mesenchymal stem cells (hUC-MSCs) was superior to hUC-MSCs alone in ameliorating high-fat diet and streptozocin-induced type II diabetes mellitus in a mouse model.
[Stem Cell Research & Therapy] |
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| Human cord blood-MSCs were isolated and characterized using flow cytometry. Cell differentiation was induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.
[Scientific Reports] |
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| Researchers suggested that nicotine exposure during pregnancy reduced transplacental transport of transthyretin and thyroid hormone to the placenta and developing fetus.
[Molecular and Cellular Endocrinology] |
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| Scientists demonstrated robust nanoparticle uptake, transgene expression, and nutrient transporter regulation without transfer to the fetus.
[Placenta] |
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| The authors examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.
[Seminars in Cell & Developmental Biology] |
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| Essent Biologics™ announced the launch of its human MSCs for regenerative medicine, biopharmaceutical and cell therapy research.
[Essent Biologics™ (PR NewsWire, Inc.)] |
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| June 15 – 18, 2022
San Francisco, California, United States |
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| European Molecular Biology Laboratory – Barcelona, Spain |
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| St. Jude Children’s Research Hospital – Memphis, Texas, United States |
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| | Stanford University – Stanford, California, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Mayo Clinic – Jacksonville, Florida, United States |
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