Cord Blood News Volume 2.35 | Sep 16 2010

Progenitor Cell Dose Determines the Pace and Completeness of Engraftment in a Xenograft Model for Cord Blood Transplantation
The studies measured the impact of progenitor cell dose on both the pace and strength of hematopoietic reconstitution by transplanting NOD/SCID-IL2Rgamma^null mice with lineage-depleted ALDH^br CD34+ human cord blood progenitors. [Blood]

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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
The identification of StemRegenin 1 and aryl hydrocarbon receptor modulation as a means to induce ex vivo hematopoietic stem cell (HSC) expansion should facilitate the clinical use of HSC therapy. [Science]

Loss of CXCL12/SDF-1 in Adult Mice Decreases the Quiescent State of Hematopoietic Stem/Progenitor Cells and Alters the Pattern of Hematopoietic Regeneration After Myelosuppression
Results indicate that CXCL12 is required for hematopoietic stem/progenitor cell homeostasis regulation and is an important factor for osteoblastic niche organization in adult stage bone marrow. [Blood]

Posttransplantation Lymphoproliferative Disorder in Children: Manifestations in Hematopoietic Cell Recipients in Comparison with Liver Recipients
Posttransplantation lymphoproliferative disorder (PTLD) after umbilical cord blood transplantation occurred as frequently as liver transplantation-related PTLD. Compared with liver transplantation-related PTLD, PTLD after hematopoietic cell transplantation is characterized by an earlier onset, a higher proportion of malignant monomorphic disease, and a worse outcome. [Radiology]

Expansion of Human Hematopoietic Cells from Umbilical Cord Blood Using Roller Bottles in CO2 and CO2 Free Atmosphere
In this work, researchers evaluated the expansion of human hematopoietic stem cells from umbilical cord blood in roller bottles. [Stem Cells Dev]

Osteogenic Differentiation of Human Wharton’s Jelly Stem Cells on Nanofibrous Substrates In Vitro
Researchers derived a novel stem cell from the human umbilical cord Wharton’s jelly that has numerous advantages over other stem cell types in that they can be harvested in abundance very efficiently and painlessly with no risk of patient morbidity, have prolonged stemness properties in vitro, are hypoimmunogenic, and can be differentiated into many tissue types in two-dimensional culture. [Tissue Eng Part A]

Intrahepatically Transplanted Human Cord Blood Cells Reduce SW480 Tumor Growth in the Presence of Bispecific EpCAM/CD3 Antibody
Data provide evidence that the intrahepatic transplantation of cord blood stem cells into newborn mice represents a valuable model for establishing functionally active human T cells with anti-tumor activity. [Cytotherapy]

Metallothionein in Human Immunomagnetically Selected CD34+ Hematopoietic Progenitor Cells
The role of metallothionein in differentiation of human haematopoietic progenitor cells from human cord blood is here reported for the first time. [Cell Biol Int]

Maintenance and Expansion of Hematopoietic Stem/Progenitor Cells in Biomimetic Osteoblast Niche
The new 3D hematopoietic progenitor cell culture system is the first to utilize natural cancellous bone as scaffold with osteoblasts as supporting cells; it is mimicry of natural bone marrow hematopoietic stem cell niche. [Cytotechnology]

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Cryo-Cell International Confirms Receipt of Unsolicited Proposal
Cryo-Cell International, Inc. confirmed that it has received an unsolicited, non-binding proposal from a private equity group to acquire all the outstanding shares of Cryo-Cell for $1.50 per share in cash. [Cryo-Cell International, Inc. Press Release]

Third Rock Ventures Raises $426 Million Fund II
Third Rock Ventures, LLC announced the final closing of Fund II, raising $426 million in an oversubscribed fund. With Fund II, Third Rock will continue to execute on its strategy and build on its successful track record of launching and supporting transformative life sciences companies. [Third Rock Ventures, LLC Press Release]

Data from Clinical Trials Show Pluristem’s Placenta-Derived Cell Therapy is Safe and Improves Quality of Life and Efficacy Measurements in Patients with Critical Limb Ischemia
Pluristem Therapeutics Inc. reported that data from clinical trials show the Company’s placenta-derived cell therapy, PLX-PAD, is safe and improves quality of life as well as other efficacy measurements in patients with Critical Limb Ischemia. [Pluristem Therapeutics Inc. Press Release]

Cell Therapeutics to Appeal FDA Decision on New Drug Application (NDA) for Pixantrone to Treat Relapsed/Refractory Aggressive Non-Hodgkin’s Lymphoma
Cell Therapeutics, Inc. announced that it intends to appeal the U.S. Food and Drug Administration’s (FDA) previously disclosed decision regarding the pixantrone New Drug Application (NDA) to treat patients with relapsed/refractory aggressive non-Hodgkin’s lymphoma. [Cell Therapeutics, Inc. Press Release]

Maryland Stem Cell Research Commission to Host Third Annual Maryland Stem Cell Research Symposium
The Maryland Stem Cell Research Commission will host the Third Annual Maryland Stem Cell Research Symposium in partnership with the National Institutes of Health and the National Institute of Standards and Technology on Wednesday, Sept. 22, 2010. [Maryland Stem Cell Research Fund Press Release]

Senator Grassley Questioning Cord Blood Banking Industry
Senator Grassley, Ranking Member of the Senate Finance Committee, announced that he is investigating the cord blood industry. In letters sent out to the major cord blood banking companies he expressed “concern” over their marketing practices. [Senate, United States]

Appeals Court Stays Stem Cell Injunction
A federal appeals court stayed, or suspended, a preliminary injunction issued two weeks ago that brought federal funding for human embryonic stem cell research to a standstill. [Court of Appeals, United States]

Senator Specter Introduces Fix to Stem Cell Ban
As Congress returned from recess, a long-time champion of biomedical research introduced the first proposal to override the 23 August court ruling that shut down federal funding for human embryonic stem cell for 17 days and could soon halt research again. [Congress, United States]

‘Sound Science’ Code Draws Fire
The first draft policy on scientific integrity from a federal agency, released by the Department of the Interior, has drawn a storm of criticism from watchdogs including the Union of Concerned Scientists, based in Cambridge, Massachusetts. [Union of Concerned Scientists, United States]

New Animal-Research Regulations for the European Union
European scientists will use fewer animals in research when newly approved regulations come into effect across the European Union. [European Parliament, European Union]

Government Sets Up Panel to Regulate Use of Stem Cells
The health ministry has approved and notified a committee to look at therapies related to stem cells and genes. [Ministry of Health, India]

NIH Statement Regarding Stay of Stem Cell Injunction [National Institutes of Health, United States]

National Heart, Lung, and Blood Institute; Notice of Meeting (FR Doc. 2010-22838) [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23024) [National Institutes of Health, Untied States]

National Institute of Mental Health Announces Availability of Funds for Competitive Revision Applications for a Repository Supporting Stem Cell Research Relevant to Mental Disorders (U24) (NOT-MH-10-032) [National Institutes of Health, United States]

July 26, 2010: Meeting of the Blood Products Advisory Committee Transcript [Center for Biologics Evaluation and Research, United States]

July 27, 2010: Meeting of the Blood Products Advisory Committee Transcript [Center for Biologics Evaluation and Research, United States]

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

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