Cord Blood News Volume 2.42 | Nov 4 2010

Umbilical Cord-Derived Mesenchymal Stromal Cells Modulate Monocyte Function to Suppress T Cell Proliferation 
Researchers report that suppression of mitogen-induced T cell proliferation by human umbilical cord-, bone marrow-, and cord blood-mesenchymal stromal cells required monocytes. [J Immunol]

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Novel RBPJ Transcripts Identified in Human Amniotic Fluid Cells
To date, four human RBPJ isoforms have been described in Entrez Gene, varying in the first 5′ coding exons. Using an improved protocol, researchers were able to further identify all four known and five novel RBPJ transcript variants in human amniotic fluid cells. [Stem Cell Rev]
 
Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma
Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for STRO1, OCT3/4 and SSEA-4 as well as the classic MSC-markers CD44, CD73, CD90, Ki67, CD105 and CD106 and negative for CD34 and CD45. [Stem Cells Dev]

Amniotic Mesenchymal Stem Cells Enhance Normal Fetal Wound Healing
Researchers conclude that fetal wound healing encompasses an autologous yet exogenous cellular component in naturally occurring amniotic mesenchymal stem cells. While seemingly not absolutely essential to the healing process, amniotic cells expedite wound closure and enhance its extracellular matrix profile. [Stem Cells Dev]
 
Differentiated Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Resource
Results suggested that differentiated-human umbilical cord mesenchymal stem cells were able to recover liver function of damaged mice. [Differentiation]
 
In Vitro Differentiation of Human Umbilical Vein Mesenchymal Stem Cells into Hepatocyte-Like Cells
Researchers concluded that umbilical cord vein mesenchymal stem cells encompass suitable hepatogenic potential which may provide a source of stem cells for cell therapy in liver diseases. [Differentiation]
 
TBI and Melphalan Followed by Allogeneic Hematopoietic SCT in Children with Advanced Hematological Malignancies
Researchers evaluated the efficacy and safety of the conditioning regimen that consisted of TBI and melphalan, followed by hematopoietic stem cell transplantation (SCT) in 23 children with advanced hematological malignancies. [Bone Marrow Transplant]

Therapy with Un-Engineered Naive Rat Umbilical Cord Matrix Stem Cells Markedly Inhibits Growth of Murine Lung Adenocarcinoma
Results indicate that rat umbilical cord matrix stem cells alone remarkably attenuate the growth of lung carcinoma cells in vitro and in a mouse syngeneic lung carcinoma graft model and could be used for targeted cytotherapy for lung cancer. [BMC Cancer]
 
Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Grow Best Under GMP-Compliant Culture Conditions and Maintain Their Phenotypic And Functional Properties
Researchers analyzed the phenotypic and functional properties of umbilical cord tissue derived mesenchymal stem cells (UCMSC) under xeno-free (containing GMP-certified human serum) and serum-free culture conditions in comparison with standard UCMSC cultures. [J Immunol Methods]

Comparison of Corneal Epitheliotrophic Capacity Among Different Human Blood-Derived Preparations
Different human blood derivatives may have different concentrations of epitheliotrophic factors. Cord blood serum is generally superior to peripheral blood serum in promoting corneal epithelial proliferation and differentiation. [Cornea]

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Cord Blood America Announces Hawaii Agreement
Cord Blood America, Inc. is pleased to announce a new work agreement with the Hawaii Medical Service Association. [Cord Blood America Press Release]
 
USF and Saneron Get $2.6 Million to Develop Alzheimer’s Treatment Using Umbilical Cord Blood Cells
The National Institutes of Health has awarded a three-year, $2.6-million grant to the University of South Florida (USF) and Tampa-based biotechnology company Saneron-CCEL Therapeutics Inc. to establish dosing and safety guidelines for transplanting human umbilical cord blood cells into animal models of Alzheimer’s disease. [EurekAlert!]
 
Soligenix Receives Award Totaling $244,479 for orBec® Program from Qualifying Therapeutic Discovery Project
Soligenix, Inc. announced that the Company has been awarded a cash grant totaling $244,479 under the U.S. Internal Revenue Service’s Qualifying Therapeutic Discovery Project program. [Soligenix, Inc. Press Release]
 
Cryo-Cell Reports Momentous Progress on the Third Anniversary of Célle
Cryo-Cell International, Inc. reported momentous progress on the third anniversary of Célle, the Company’s proprietary menstrual stem cell technology service. [Cryo-Cell International, Inc. Press Release]
 
Qatar to Have Region’s First Stem Cells Laboratory
Preparations are on to set up a stem cells transplant unit in Al Amal Hospital by the year-end to provide optimal care to patients in need of advanced techno-therapy and are unable to afford treatment abroad, an official source at Hamad Medical Corporation (HMC) said. [The Peninsula]

Private Cord Blood Banks Illegal in UAE
Private companies in the UAE cannot store umbilical cord blood, according to Amin Al Amiri, Executive Director for Medical Practices and Licensing at the Ministry of Health. [Ministry of Health, United Arab Emirates]
 
Korean Supreme Court Rules Stem Cells as Medicine
The Supreme Court has ruled that stem cells used to treat illnesses should be regarded as medicine that requires approval from the drug administration for use. [Supreme Court, Korea]
 
NIH Introduces Images, a Database of Images in Biomedical Literature
More than 2.5 million images and figures from medical and life sciences journals are now available through Images, a new resource for finding images in biomedical literature. [National Institutes of Health, United States]
 
Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-27842) [Department of Health and Human Services, United States]
 
Cellular, Tissue and Gene Therapies Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]
 
Cellular, Tissue and Gene Therapies Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]
 
National Heart, Lung, and Blood Institute; Notice of Closed Meetings (FR Doc. 2010-27319) [National Institutes of Health, United States]
 
National Heart, Lung, and Blood Institute; Notice of Meetings (FR Doc. 2010-27318) [National Institutes of Health, United States]
 
Guidelines for Use of Stored Specimens and Access to Ancillary Data and Proposed Cost Schedule: Stored Biologic Specimens and Ancillary Data From the Collaborative Perinatal Project (CPP) (FR Doc. 2010-27183) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27743) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-27410) [National Institutes of Health, United States]
 
National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-27562) [National Institutes of Health, United States]

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

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