HHV-6 Reactivation and Its Effect on Delirium and Cognitive Functioning in Hematopoietic Cell Transplant Recipients Patients with HHV-6 were more likely to develop delirium (adjusted odds ratio (aOR) 2.5; 95% confidence interval (CI) 1.2-5.3) and demonstrate neurocognitive decline (aOR 2.6; 95% CI 1.1-6.2) in the first 84 days post hematopoietic cell transplantation. Cord blood and unrelated transplantation increased risk of HHV-6 reactivation. [Blood] Amniotic Liquid Derived Stem Cells as Reservoir of Secreted Angiogenic Factors Capable of Stimulating Neo-Arteriogenesis in an Ischemic Model Researchers used human amniotic fluid stem cells (AFSC) to evoke a strong angiogenic response in murine recipients, in terms of host guided-regeneration of new vessels, and we demonstrated that the AFSC secretome is responsible for the vascularizing properties of these cells. [Biomaterials] The Treatment of Neurodegenerative Disorders Using Umbilical Cord Blood and Menstrual Blood-Derived Stem Cells Mononuclear umbilical cord blood cells and menstrual blood-derived stem cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer’s disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. [Cell Transplant] MMP-2 Mediates Mesenchymal Stem Cell Tropism Towards Medulloblastoma Tumors Researchers conclude that human umbilical cord blood-derived stem cells can integrate into human medulloblastoma after local delivery and that matrix metalloproteinase (MMP)-2 expression by the tumor cells mediates this response through the stromal cell-derived factor 1/CXCR4 axis. [Gene Ther] Unrelated Cord Blood Transplantation for Thalassemia: A Single-Institution Experience of 35 Patients Data compare acceptably with the survival rates of related-donor BMT for thalassemia and suggest that patients without an available HLA-compatible sibling but who have well-matched unrelated donors should also be considered for cord blood transplantation. [Bone Marrow Transplant] Identification and Frequency of CCR5Δ32/Δ32 HIV-Resistant Cord Blood Units from Houston Area Hospitals Routine genotyping to identify HIV-resistant cord blood (CB) units could create a bank of CB-derived stem/progenitor cells with which to treat HIV infection. [HIV Med] Successful Treatment with Combined Chemotherapy of Two Adult Cases of Hemophagocytic Lymphohistiocytosis in Recipients of Umbilical Cord Blood Cell Transplantation The combined use of low-dose etoposide and vincristine plus prednisolone appears to be a promising treatment option for hematopoietic stem cell transplantation-hemophagocytic lymphohistiocytosis, without serious adverse side effects. [Int J Hematol] MARCH-I Expression in Cord Blood CD34+KDR+ Cells MARCH-I expression in stem cells could be important for their intrinsic immune properties. [Clin Biochem] The Preparation and Storage of Dried-Blood Spot Quality Control Materials for Lysosomal Storage Disease Screening Tests Umbilical-cord blood is the preferred matrix for lysosomal storage disease-normal dried-blood spot quality control materials. [Clin Biochem] Delivery of Fibroblast Growth Factor 2 Enhances the Viability of Cord Blood-Derived Mesenchymal Stem Cells Transplanted to Ischemic Limbs Researchers hypothesized that local delivery of fibroblast growth factor 2 to the site of cord blood-derived mesenchymal stem cell (CBMSC) transplantation would enhance the viability of CBMSCs transplanted to ischemic tissues. [J Biosci Bioeng] |