Cord Blood News Volume 3.15 | Apr 21 2011

Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models
Dimethyl-prostaglandin E2 significantly increased total human hematopoietic colony formation in vitro and enhanced engraftment of unfractionated and CD34+ human cord blood after xenotransplantation. [Cell Stem Cell]

Contamination of Mesenchymal Stem Cells with Fibroblasts Accelerates Neurodegeneration in an Experimental Model of Parkinson’s Disease
Researchers show for the first time that transplantation of umbilical cord-derived mesenchymal stem cells induced potent neuroprotection in the brain resulting in clinical benefit. [Stem Cell Rev]

Generation of Hematopoietic Humanized Mice in the Newborn BALB/c-Rag2^nullIl2rγ^null Mouse Model: A Multivariable Optimization Approach
This study was performed to generate a protocol that improves development and quality of humanized mice in the BALB/c-Rag2^nullIl2rγ^null strain, testing route of injection, in vitro culture and freezing of human hematopoietic stem cells, types of cytokines in the culture, and co-injection of lineage-depleted CD34^– cells. [Clin Immunol]

Effective Treatment of Severe Steroid-Resistant Acute Graft-Versus-Host Disease with Umbilical Cord-Derived Mesenchymal Stem Cells
Researchers compared umbilical cord-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells for morphology, surface markers expression, differentiation, proliferative potential, and their suppressive effects on peripheral blood mononuclear cell proliferation. [Transplantation]

CD34+ Cord Blood DC-Induced Antitumor Lymphoid Cells Have Efficacy in a Murine Xenograft Model of Human ALL
Researchers postulate that cytotoxic T lymphocytes generated from total RNA loaded cord blood CD34+-derived dendritic cells can control the kinetics of leukemic growth in a nonobese diabetic/severe combined immunodeficient mouse model of human acute lymphocytic leukemia (ALL). [J Immunother]

Paracrine Regulation of Megakaryo/Thrombopoiesis by Macrophages
The different stages of megakaryo/thrombopoiesis were analyzed by flow cytometry using an in vitro model of human cord blood CD34+ cells stimulated with thrombopoietin in either a transwell system or conditioned media from monocyte-derived macrophages isolated from peripheral blood. [Exp Hematol]

Allogeneic Cellular Gene Therapy in Hemoglobinopathies – Evaluation of Hematopoietic SCT in Sickle Cell Anemia
Data confirmed SCT from a suitable HLA-matched, related donor should become the primary option for curing children with sickle cell anemia. [Bone Marrow Transplant]

Use of a Precious Resource: Parental Decision Making About Using Autologous Umbilical Cord Blood in Studies Involving Young Children with Type 1 Diabetes
Researchers aimed to assess parental decision making and experiences in an autologous umbilical cord blood infusion study in young children with type 1 diabetes. [Contemp Clin Trials]

Quality Assessment of Umbilical Cord Blood Units at the Time of Transplantation
Researchers suggest that the total nucleated cell count and CD34+ cell content estimated before cryopreservation and in pre-transplant release tests provided by cord blood banks are reproducible and can assist the transplant physicians in selection of appropriate umbilical cord blood units. [Int J Hematol]

The Current Status of Umbilical Cord Blood Collection in Japanese Medical Centers: Survey of Obstetricians
The aim of this study was to reveal the current status of umbilical cord blood (UCB) collection and discuss the management of the UCB bank. [Transfus Apher Sci]

Cryo-Save India Set to Expand Cord Blood Banking Business to Rural Areas in North, Western Regions
Cryo-Save India, the largest adult stem cell and cord blood bank in the country is looking forward to expand its presence in the rural market. The company has already invested $ 3 million during the last two years and is now working out modalities to expand its foot print to north and western India. [PharmaBiz]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 4th Stem Cells Europe
July 20-21, 2011
Edinburgh, Scotland

Visit our events page to see a complete list of events in the cord blood community.

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Quality Assurance Manager – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

INTERBIO-21st Project Coordinator (University of Oxford – Nuffield Department of Obstetrics & Gynaecology)

Senior Scientist (Matchtech)

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