Cord Blood News Volume 3.17 | May 5 2011

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Improve Glucose Homeostasis in Rats with Liver Cirrhosis
Researchers investigated whether umbilical cord blood-derived mesenchymal stem cells have an effect on the expression of molecules responsible for glucose utilization and hepatic gluconeogenesis, focusing on the insulin signaling pathway in rats with liver cirrhosis. [Int J Oncol]

Pomalidomide Augments Fetal Hemoglobin Production without the Myelosuppressive Effects of Hydroxyurea in Transgenic Sickle Cell Mice
Researchers investigated the effects of pomalidomide on erythropoiesis and hemoglobin synthesis in a transgenic mouse model of sickle cell disease. [Blood]

Endothelial Fate and Angiogenic Properties of Human CD34+ Progenitor Cells in Zebrafish
In the present study, human cord blood–derived CD34+ cells were transplanted into pre- and postgastrulation zebrafish embryos and in an adult vascular regeneration model induced by caudal fin amputation. [Arterioscler Thromb Vasc Biol]

Optimal Conditions for Lentiviral Transduction of Engrafting Human CD34+ Cells
Researchers sought to optimize transduction and engraftment of human CD34+ cells using lentiviral vectors. [Gene Ther]

A Comparison of Methods for Quantifying Angiogenesis in the Matrigel Assay In Vitro
Here, researchers have measured the ability of umbilical cord blood endothelial colony forming cell derived cells to form tubules in Growth Factor Reduced Matrigel in the presence or absence of two angiogenic inhibitors, suramin and SU6668, in order to compare the benefits and limitations of two quantification methods – Angiosys and Wimasis. [Tissue Eng Part C Methods]

Estradiol and Progesterone Strongly Inhibit the Innate Immune Response of Newborn Mononuclear Cells
Here researchers show that, at concentrations present in umbilical cord blood, estradiol and progesterone are as powerful as hydrocortisone to inhibit cytokine production by cord blood mononuclear cells and newborn monocytes. [Infect Immun]

The CYP4A/F-20-HETE System in Regulation of Endothelial Precursor Cell Derived from Human Umbilical Cord Blood
Researchers studied whether angiogenic effects of the CYP4A/F-20-HETE system involves regulation of endothelial precursor cell (EPC) function. They isolated EPC from human umbilical cord blood. [J Pharmacol Exp Ther]

Xenogeneic Immunosuppression of Human Umbilical Cord Mesenchymal Stem Cells in a Major Histocompatibility Complex (MHC)-Mismatched Allogeneic Acute Graft-versus-Host Disease Murine Model
In this study, researchers investigated the influence of xenogeneic human umbilical cord mesenchymal stem cells on acute graft-versus-host-disease in murine allogenic bone marrow transplantation. [Eur J Haematol]

The Mixed Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Show Higher Antitumor Effect Against C6 Cells than the Single In Vitro
The data collected herein confirm for the first time that the mixed umbilical cord blood mesenchymal stem cells (UCB-MSCs) were shown to have more cytotoxic effects than the single UCB-MSCs through increasing the expression of caspase-3 and decreasing the expression of CD133 in C6 glioma cells. [Neurol Res]

Quality Assessment of Umbilical Cord Blood Units at the Time of Transplantation
The aim of this study was to compare the umbilical cord blood (UCB) characteristics analyzed at the site of infusion of the UCB with those provided by cord blood banks (CBBs). [Int J Hematol]

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