Cord Blood News Volume 3.29 | Jul 28 2011

Combined Growth Factors Enhance the Angiogenic Potential of Human Cord Blood-Derived Mononuclear Cells Transplanted to Ischemic Limbs
This study aimed to enhance the survival and angiogenic capacity of human umbilical cord blood-derived mononuclear cells and to demonstrate their therapeutic effects on experimental ischemia. [J Mol Cell Cardiol]

Girl with Cerebral Palsy Treated with Own Cord Blood Stem Cells
Medical doctors are treating cerebral palsy patients who have their own cord blood stored, in a clinical trial. [Cryo-Save AG Press Release]

Innate Signals Overcome Acquired TCR Signaling Pathway Regulation and Govern the Fate of Human CD161^hi CD8α⁺ Semi-Invariant T Cells
Researchers describe acquired regulation of T cell receptor (TCR) signaling in adult memory CD161^hiCD8α⁺ T cells that is absent in cord CD161^hi cells and adult CD161^lo cells. [Blood]

Gestational Diabetes Mellitus Causes Changes in the Concentrations of Adipocyte Fatty Acid-Binding Protein and Other Adipocytokines in Cord Blood
The objectives of this study were to determine the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in maternal and cord serum of pregnant women with gestational diabetes mellitus and of control subjects and to relate them to indexes of insulin sensitivity. [Diabetes Care]

Differential Effects of HOXB4 and NUP98-HOXA10hd on Hematopoietic Repopulating Cells in a Nonhuman Primate Model
Researchers show that HOXB4 and NUP98-HOXA10hd both have a significant impact on hematopoietic reconstitution; however, these effects are differential and therefore may offer complementary strategies for hematopoietic stem cell expansion. [Hum Gene Ther]

Mitochondrial Function and Energy Metabolism in Umbilical Cord Blood and Bone Marrow-Derived Mesenchymal Stem Cells
This work focuses on the mitochondrial function of human mesenchymal stem cells from umbilical cord blood cells and bone marrow cells from donors younger than 18 years of age (BMMSC <18) and those more than 50 years of age (BMMSC >50). [Stem Cells Dev]

Very Small Embryonic-Like Stem Cells with Maximum Regenerative Potential Get Discarded During Cord Blood Banking and Bone Marrow Processing for Autologous Stem Cell Therapy
Results show that very small embryonic-like stem cells, which are pluripotent stem cells with maximum regenerative potential, settle along with the red blood cells during Ficol-Hypaque density separation. [Stem Cells Dev]

Increased Numbers of Total Nucleated and CD34+ Cells in Blood Group O Cord Blood: An Analysis of Neonatal Innate Factors in the Korean Population
Investigators analyzed neonatal factors that could affect hematopoietic variables of cord blood donated from Korean neonates. [Transfusion]

The Complex Relationship Between Human Herpes Virus 6 and Acute Graft-Versus-Host Disease
In this retrospective analysis of 365 patients who underwent allogeneic hematopoietic stem cell transplantation, human herpes Virus 6 reactivation was significantly associated with cord blood transplantation and the use of unrelated donors. [Biol Blood Marrow Transplant]

Wilms’ Tumor 1-Specific Cytotoxic T Lymphocytes Can Be Expanded from Adult Donors and Cord Blood
Researchers demonstrate that Wilms’ tumor 1-specific cytotoxic T lymphocytes (WT1-CTL) can be generated from healthy adult donors and from cord blood by stimulating with an overlapping pool of peptides derived from full length WT1 and selecting antigen-specific cells based on the expression of CD137. [Leuk Res]

FDA Grants TM-400 Orphan Drug Designation for Mobilization of Stem Cells Used to Treat Hematologic Cancer in the U.S.
TikoMed AB announced that the U.S. Food and Drug Administration (FDA) has granted TM-400 Orphan Drug Designation for the mobilization of stem cells prior to stem cell transplantation treatment. [TikoMed AB Press Release]

Florida Blood Bank Merger
The Boards of Directors for three of Florida’s independent, not-for-profit blood banks, Community Blood Centers of Florida, Inc., Florida’s Blood Centers, Inc. and Florida Blood Services, Inc. have voted to merge. [Florida Blood Services Press Release]

Scientist (iPSC) (STEMCELL Technologies)

Industrial Postdoctoral Research Fellow (Regenerative Medicine Cell Therapy) (Tissue Regeneration Therapeutics Inc.)

Cord Blood Procurement Specialist (Karmanos Cancer Institute)

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