Cord Blood News Volume 4.00 | Jan 5 2012

Interaction Between Differentiating Cell- and Niche-Derived Signals in Hematopoietic Progenitor Maintenance
Here, researchers show that the hematopoietic progenitors also require a signal mediated by adenosine deaminase growth factor A arising from differentiating cells that regulates extracellular levels of adenosine. [Cell] Abstract | Press Release

Cord Blood Tregs with Stable FOXP3 Expression Are Influenced by Prenatal Environment and Associated with Atopic Dermatitis at the Age of One Year
Regulatory T cells (Tregs) with stable FOXP3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific demethylated region, TSDR). The aim of this study was to analyze the influence of prenatal factors on cord blood Treg numbers, as detected by changes in the TSDR demethylation, and the subsequent risk for allergic diseases. [Allergy] Abstract

Compartmental Hollow Fiber Capillary Membrane-Based Bioreactor Technology for In Vitro Studies on Red Blood Cell Lineage Direction of Hematopoietic Stem Cells
CD34⁺ hematopoietic stem cells were isolated from human cord blood units using a magnetic separation procedure. Down-scaled culture technology allowed for expansion of CD34⁺ cells and stimulating these progenitors towards red blood cell lineage, expressing approximately 40% CD235⁺ and enucleation. [Tissue Eng Part C Methods] Abstract

Factors Affecting Microbial Contamination Rate of Cord Blood Collected for Transplantation
Cord blood was collected and processed using a closed system and tested for contamination using blood culture bottles incubated for a minimum of 5 days. [Transfusion] Abstract

High Incidence of Radiation Induced Cavernous Hemangioma in Long-Term Survivors Who Underwent Hematopoietic Stem Cell Transplantation with Radiation Therapy during Childhood or Adolescence
Long-term surviving hematopoietic stem cell transplant (HSCT) recipients who have received radiation therapy could be at risk of radiation induced cavernous hemangioma. Scientists investigated records for 68 patients who underwent HSCT during childhood or adolescence. [Biol Blood Marrow Transplant] Abstract

Nicotinamide, a Sirtuin Inhibitor, Inhibits Differentiation and Facilitates Expansion of Hematopoietic Progenitor Cells with Enhanced Bone Marrow Homing and Engraftment
Here investigators report that nicotinamide delayed differentiation and increased engraftment efficacy of cord blood-derived human CD34⁺ cells cultured with cytokines. [Exp Hematol] Abstract

Fludarabine, Melphalan, Thiotepa and Anti-Thymocyte Globulin Conditioning for Unrelated Cord Blood Transplant
Unrelated cord blood transplant is an alternative treatment option for patients who lack a matched donor. Researchers evaluated the toxicity and outcomes of a conditioning regimen consisting of melphalan 140 mg/m² (day – 8), thiotepa 10 mg/kg (day – 7), fludarabine 160 mg/m² over 4 days (days – 6 to – 3) and rabbit antithymocyte globulin 1.25 mg/kg (day – 4) and 1.75 mg/kg (day – 3). [Leuk Lymphoma] Abstract

Intrahepatic Transplantation of CD34⁺ Cord Blood Stem Cells into Newborn and Adult NOD/SCID Mice Induce Differential Organ Engraftment
In the present paper researchers describe the effect of intrahepatically transplanted CD34⁺ cells from cord blood into the liver of newborn or adult NOD/SCID mice on organ engraftment and differentiation. [Tissue Cell] Abstract

Cord Blood America to Store Stem Cells for National Children’s Leukemia Foundation
Cord Blood America, Inc. is pleased to announce it has signed an exclusive agreement to store stem cells at its Las Vegas laboratory for the National Children’s Leukemia Foundation, New York. [Cord Blood America, Inc.] Press Release

Future Health BIOBANK Director Awarded MBE for Services to Science
The UK Director of Europe’s first accredited private family stem cell bank, Future Health BIOBANK, has been awarded an MBE for services to scientific research and training in the Queen’s New Year’s honors list. [Future Health BIOBANK] Press Release

ThermoGenesis Announces Approval of AXP^® by India Ministry of Health
ThermoGenesis Corp. said that India’s Ministry of Health has approved the AutoXpress^® System (AXP), enabling the Company to initiate commercial sales of the product in India. The AXP is used for the processing of stem cells from cord blood. [ThermoGenesis Corp.] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

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