Cord Blood News Volume 4.02 | Jan 19 2012

Engraftment of Human HSC in Non-Irradiated Newborn NOD-scidIL2rγ^null Mice Is Enhanced by Transgenic Expression of Membrane-Bound Human Stem Cell Factor
Researchers hypothesized that transgenic expression of human membrane-bound stem cell factor would increase levels of human hematopoietic stem cell (HSC) engraftment in non-irradiated NOD-scidIL2rγ^null (NSG) mice and eliminate complications associated with irradiation. Surprisingly, detectable levels of human CD45+ cell chimerism were observed following transplantation of cord blood-derived human HSC into non-irradiated adult as well as newborn NSG mice. [Blood] Abstract

Unrelated Cord Blood Transplantation for Newly Diagnosed Patients with Severe Acquired Aplastic Anemia Using a Reduced-Intensity Conditioning: High Graft Rejection, but Good Survival
Investigators report a single-center experience in treating 18 consecutive patients with severe aplastic anemia who received unrelated cord blood transplantation. [Bone Marrow Transplant] Abstract

The Use of Back-Up Units to Enhance the Safety of Unrelated Donor Cord Blood Transplantation
Researchers demonstrate that back-up units are emergently required in a significant minority of patients supporting the incorporation of at least one back-up unit in cord blood (CB) selection algorithms to enhance CB transplantation. [Biol Blood Marrow Transplant] Abstract

Production of Large Numbers of Plasmacytoid Dendritic Cells with Functional Activities from CD34+ Hematopoietic Progenitor Cells: Use of Interleukin-3
As plasmacytoid dendritic cells (pDC) represent a rare cell type in the peripheral blood, the goal of this study was to develop a new method to efficiently generate large numbers of cells from a limited number of CD34+ cord blood progenitors in order to provide a tool to resolve important questions about how pDC mediate tolerance, autoimmunity and cancer. [Exp Hematol] Abstract

Polyunsaturated Fatty Acids Confer Cryoresistance on Megakaryocytes Generated from Cord Blood and Also Enhance Megakaryocyte Production from Cryopreserved Cord Blood Cells
In this study, cryopreservation of ex vivo-expanded megakaryocytes (MK) as well as MK generation from cryopreserved umbilical cord blood samples was investigated. [Cytotherapy] Abstract

Ectopic Expression of the Histone Methyltransferase Ezh2 in Hematopoietic Stem Cells Causes Myeloproliferative Disease
Here researchers show that induced Ezh2 hematopoietic expression increases the number and proliferation of repopulating hematopoietic stem cells. [Nat Commun] Abstract

CIRM Allocates $40 Million to Support Stem Cell Genomics, Speeding Development of Therapies for Patients
California stem cell scientists will have a new resource for advancing therapies with a $40 million initiative approved today by the governing board of the California Institute for Regenerative Medicine (CIRM). [California Institute for Regenerative Medicine] Press Release

Making Safer Chemicals: New NIH Grant Helps Researchers Study How Chemicals in Drugs and Around Us Impact Stem Cells
Bioengineers at Rensselaer Polytechnic Institute and the University of California, Berkeley, have been awarded a more than $2 million grant from the National Institutes of Health (NIH) to study how chemicals in drugs and our environment impact our stem cells. [Rensselaer Polytechnic Institute] Press Release

SpineSmith Adds Talented Scientist to Research and Development Team
SpineSmith is pleased to announce the addition of Dr. Matthew Murphy to its team of PhDs. [PR Newswire] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

Cell Therapy Technician (Kelly Scientific Resources)


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